Abstract:
:C-type lectins can act as pattern recognition receptors (PRRs) in innate immunity. Previously, we identified two C-type lectins from silkworm (Bombyx mori), BmLBP and BmMBP, as PRRs. In the present study, we identified three homologs of these lectins by searching the silkworm genome database. These novel B. mori low-expression lectins were designated BmLEL-1, BmLEL-2, and BmLEL-3. Although Western-blot analysis failed to detect BmLEL-1, -2, or -3 in plasma, affinity precipitation of larval plasma with various microorganisms revealed that BmLEL-1 and -2 bind to rough and smooth strains of Gram-negative bacteria, respectively. BmLEL-1, -2, and -3 were found to be expressed in testis and ovary, where BmLEL-2 expression was up-regulated after bacteria infection. These results indicate that the novel C-type lectins might play a role in the innate immunity in these tissues as PRRs. Here, we discuss the roles and members of the C-type lectins as primary PRRs in B. mori cellular immunity.
journal_name
Dev Comp Immunoljournal_title
Developmental and comparative immunologyauthors
Takase H,Watanabe A,Yoshizawa Y,Kitami M,Sato Rdoi
10.1016/j.dci.2009.01.005subject
Has Abstractpub_date
2009-06-01 00:00:00pages
789-800issue
6eissn
0145-305Xissn
1879-0089pii
S0145-305X(09)00018-4journal_volume
33pub_type
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