Abstract:
:Infectious bursal disease (IBD) is an economically important immunosuppressive disease of chickens. The IBD virus (IBDV) actively replicates in B cells and causes severe bursal damage. Generally, T cells are refractory to infection with IBDV but are known to promote virus clearance. However, the mechanisms of T cell mediated viral clearance are not well understood. In this study, we evaluated the molecular mechanisms of cytotoxic T cell responses in the pathogenesis of IBD in chickens. Infection of chickens with IBDV was accompanied by the infiltration of CD4(+) and CD8(+) T cells in the bursa. There was an upregulation in the gene expression of important cytolytic molecules; perforin (PFN), granzyme-A (Gzm-A), DNA repair and apoptotic proteins; high mobility proteins group (HMG) and poly (ADP-ribose) polymerase (PARP) in the bursa of Fabricius (BF) whereas expression of NK (natural killer) lysin was downregulated. Importantly, PFN producing CD4(+) and CD8(+) T cells were also detected in the bursa of IBDV-infected chickens by immunohistochemistry. The Th1 cytokines, IL-2 and IFN-γ expression was also strongly upregulated, suggesting the activation of T cells. The findings of this study highlight the mechanisms of IBD pathogenesis and the role of cytotoxic T cells in the clearance of virus-infected cells.
journal_name
Dev Comp Immunoljournal_title
Developmental and comparative immunologyauthors
Rauf A,Khatri M,Murgia MV,Saif YMdoi
10.1016/j.dci.2011.01.007subject
Has Abstractpub_date
2011-05-01 00:00:00pages
620-7issue
5eissn
0145-305Xissn
1879-0089pii
S0145-305X(11)00008-5journal_volume
35pub_type
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journal_title:Developmental and comparative immunology
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journal_title:Developmental and comparative immunology
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journal_title:Developmental and comparative immunology
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journal_title:Developmental and comparative immunology
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journal_title:Developmental and comparative immunology
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journal_title:Developmental and comparative immunology
pub_type: 杂志文章
doi:10.1016/j.dci.2008.09.003
更新日期:2009-02-01 00:00:00
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journal_title:Developmental and comparative immunology
pub_type: 杂志文章,评审
doi:10.1016/j.dci.2021.104021
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journal_title:Developmental and comparative immunology
pub_type: 杂志文章
doi:10.1016/j.dci.2004.10.001
更新日期:2005-01-01 00:00:00
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journal_title:Developmental and comparative immunology
pub_type: 杂志文章
doi:10.1016/j.dci.2015.06.001
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journal_title:Developmental and comparative immunology
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doi:10.1016/j.dci.2018.03.005
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journal_title:Developmental and comparative immunology
pub_type: 杂志文章,评审
doi:
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journal_title:Developmental and comparative immunology
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journal_title:Developmental and comparative immunology
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journal_title:Developmental and comparative immunology
pub_type: 杂志文章
doi:10.1016/j.dci.2013.07.017
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journal_title:Developmental and comparative immunology
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doi:10.1016/j.dci.2009.11.009
更新日期:2010-04-01 00:00:00
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journal_title:Developmental and comparative immunology
pub_type: 杂志文章
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journal_title:Developmental and comparative immunology
pub_type: 杂志文章
doi:10.1016/j.dci.2013.11.012
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journal_title:Developmental and comparative immunology
pub_type: 杂志文章
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journal_title:Developmental and comparative immunology
pub_type: 杂志文章
doi:10.1016/j.dci.2007.03.006
更新日期:2007-01-01 00:00:00
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journal_title:Developmental and comparative immunology
pub_type: 杂志文章
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journal_title:Developmental and comparative immunology
pub_type: 杂志文章
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abstract::The expression levels of 97 unigenes encoding heat shock proteins of Litopenaeus vannamei was scanned, and ten of them were significantly induced by white spot syndrome virus (WSSV). Among these genes, heat shock 70 kDa protein cognate 5 (LvHSC70-5) was upregulated to the highest extent and subjected to further studie...
journal_title:Developmental and comparative immunology
pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00