Abstract:
:The cartilaginous fish (chimeras, sharks, skates and rays) are the oldest group relative to mammals in which an adaptive immune system founded upon immunoglobulins has been found. In this manuscript we characterize the immunoglobulins of the spiny dogfish (Squalus acanthias) at both the molecular and expressed protein levels. Despite the presence of hundreds of IgM clusters in this species the serum levels of this isotype are comparatively low. However, analysis of cDNA sequences and serum protein suggests microheterogeneity in the IgM heavy chains and supports the proposal that different clusters are preferentially used in the two forms (monomer or pentamer) of this isotype. We also found that the IgNAR isotype in this species exists in a previously unknown multimeric format in serum. Finally, we identified a new form of the IgW isotype (the shark IgD orthologue), in which the leader is spliced directly to the first constant domain, resulting in a molecule lacking an antigen-binding domain.
journal_name
Dev Comp Immunoljournal_title
Developmental and comparative immunologyauthors
Smith LE,Crouch K,Cao W,Müller MR,Wu L,Steven J,Lee M,Liang M,Flajnik MF,Shih HH,Barelle CJ,Paulsen J,Gill DS,Dooley Hdoi
10.1016/j.dci.2011.10.007subject
Has Abstractpub_date
2012-04-01 00:00:00pages
665-79issue
4eissn
0145-305Xissn
1879-0089pii
S0145-305X(11)00291-6journal_volume
36pub_type
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