Abstract：
:To date, most studies on pinniped immunoglobulins have focused on circulating antibodies. However, systemic and local immune activities differ in terms of maturation, intensity, and types of effectors that participate. Here, we examined levels of three immunoglobulin isotypes, IgG, IgM and IgA, in the blood and mucosal membranes of free-living California sea lion pups. We investigated whether age, body condition and sex influenced their concentration. Isotype levels varied among tissues, with age-related patterns that could be indicative of differential regulation along development. Serum IgG and IgA increased linearly with age, reaching adult levels at five months of age, while IgM remained unchanged. Mucosal isotypes tended to be low in newborns and remained so until five months of age. Regardless of age, pups with better condition tended to have higher anal IgG levels and higher genital IgA levels, suggesting that their synthesis and transport to the mucosal membranes is costly. Intersex differences were only observed in the genital mucosa, where all isotypes differed between male and female pups, regardless of age, presumably due to histological and anatomical differences.
journal_name
Dev Comp Immunoljournal_title
Developmental and comparative immunologyauthors
Espinosa-de Aquino W,Bailey M,Acevedo-Whitehouse Kdoi
10.1016/j.dci.2017.08.006subject
Has Abstractpub_date
2017-12-01 00:00:00pages
166-173eissn
0145-305Xissn
1879-0089pii
S0145-305X(17)30223-9journal_volume
77pub_type
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journal_title：Developmental and comparative immunology
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