In vitro interaction of Perkinsus marinus merozoites with eastern and Pacific oyster hemocytes.


:This study compared hemocyte responses of eastern and Pacific oysters to Perkinsus marinus, in vitro. Except for the percentage of hemocytes associated with P. marinus there was little or no significant difference between eastern and Pacific oysters with regard to their hemocytic response to P. marinus. In phagocytosis assays, merozoites were bound to all hemocyte types but in unequal proportions, unlike zymosan which was found predominantly associated with granulocytes. The number of merozoites enlarging in Ray's fluid thioglycollate medium after incubation with hemocytes in plasma for one day was significantly lower than after incubation in plasma alone in both oyster species. Electron microscopy or merozoites indicated that the parasites were rapidly phagocytosed and that some of the merozoites showed signs of degeneration in less than 12 h. The results suggest that limited intracellular killing of P. marinus had occurred, but was probably not mediated by oxygen metabolites, since no increase in chemiluminescence was observed when hemocytes of either eastern or Pacific oysters were exposed to merozoites.


Dev Comp Immunol


La Peyre JF,Chu FL,Vogelbein WK




Has Abstract


1995-07-01 00:00:00














  • The effect of aging on T cell responses in the horse.

    abstract::Horses greater than 20 years of age exhibit alterations in their immune responses similar to those observed in other aged individuals. The purpose of this study was to characterize immunosenescence in a population of aged ponies. The peripheral blood mononuclear cells (PBMC) from aged ponies exhibited a decreased prol...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Horohov DW,Kydd JH,Hannant D

    更新日期:2002-01-01 00:00:00

  • CsTNF1, a teleost tumor necrosis factor that promotes antibacterial and antiviral immune defense in a manner that depends on the conserved receptor binding site.

    abstract::Tumor necrosis factor (TNF) is one of the most important cytokines involved in inflammation, apoptosis, cell proliferation, and stimulation of the immune system. The TNF gene has been cloned in teleost fish; however, the in vivo function of fish TNF is essentially unknown. In this study, we report the identification o...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Li MF,Zhang J

    更新日期:2016-02-01 00:00:00

  • Penaeus vannamei serine proteinase inhibitor 7 (LvSerpin7) acts as an immune brake by regulating the proPO system in AHPND-affected shrimp.

    abstract::Acute hepatopancreatic necrosis disease (AHPND) is a recently emerged disease in aqua cultured shrimp that is caused by virulent strains of Vibrio parahaemolyticus (VP). Our previous study used transcriptomics to identify key pathogenic factors in the stomach of AHPND-infected shrimp (Litopenaeus vannamei), and here w...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Apitanyasai K,Chang CC,Ng TH,Ng YS,Liou JH,Lo CF,Lin SS,Wang HC

    更新日期:2020-05-01 00:00:00

  • Characterization and role of suppressor of cytokine signaling 1a (SOCS1a) in a teleost fish, Miichthys miiuy.

    abstract::The suppressor of cytokine signaling 1 (SOCS1) is a crucial regulator in the immune systems of mammals, which functions classically as a negatively regulator in the IFN signaling pathways. However, data on functional characterization of SOCS1 in lower vertebrates is limited. In this study, we identified and characteri...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Zhao X,Huo R,Song W,Xu T

    更新日期:2018-01-01 00:00:00

  • Lymphoid follicles of different phenotype appear in ileum during involution of the sheep ileal Peyer's patch.

    abstract::The ileal Peyer's patch (IPP) of young sheep is a site of diversification of the primary antibody repertoire and where involution takes place at young age. Tissue samples from the ileum were collected in 134 animals aged from 1 month to 6 years, and IPP follicle phenotypes were characterised. We describe a new type of...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Lie KI,Aleksandersen M,Landsverk T

    更新日期:2005-01-01 00:00:00

  • Molecular characterization and function of a PTEN gene from Litopenaeus vannamei after Vibrio alginolyticus challenge.

    abstract::PTEN, a tumor suppressor gene, suppresses cell survival, growth, apoptosis, cell migration and DNA damage repair by inhibiting the PI3K/AKT signaling pathway. In this study, the full-length Litopenaeus vannamei PTEN (LvPTEN) cDNA was obtained, containing a 5'UTR of 59bp, an ORF of 1269bp and a 3'UTR of 146bp besides t...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Xie CY,Kong JR,Zhao CS,Xiao YC,Peng T,Liu Y,Wang WN

    更新日期:2016-06-01 00:00:00

  • Identification, characterization and bioactivity of tumor necrosis factor (TNF)-related apoptosis-inducing ligand from Equus caballus.

    abstract::Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily and plays multifunctional roles in the immune system. In the present study, a homolog of TRAIL from the Mongolian horse (named ecTRAIL) was identified and characterized. The 870-bp open reading frame encodes a poly...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Ma L,Sang M,Zhang J,Zhang S

    更新日期:2017-02-01 00:00:00

  • A novel C-type lectin (FcLec4) facilitates the clearance of Vibrio anguillarum in vivo in Chinese white shrimp.

    abstract::C-type lectins play important roles in innate immunity of invertebrates. In the present study, we report a novel C-type lectin, named FcLec4, from the Chinese white shrimp Fenneropenaeus chinensis. FcLec4 contains a single carbohydrate recognition domain (CRD) with a putative signal peptide. Phylogenetic analysis indi...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Wang XW,Zhang XW,Xu WT,Zhao XF,Wang JX

    更新日期:2009-09-01 00:00:00

  • Identification of a novel relish homolog in Chinese shrimp Fenneropenaeus chinensis and its function in regulating the transcription of antimicrobial peptides.

    abstract::Penaeid shrimp, as an invertebrate, relies on the innate immunity to oppose the microbial invaders. Antimicrobial peptides (AMP) are an integral component of the innate immune system in most organisms and function as an early first line of defense against pathogens, but the knowledge about the pathways to regulate the...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Li F,Yan H,Wang D,Priya TA,Li S,Wang B,Zhang J,Xiang J

    更新日期:2009-10-01 00:00:00

  • Mucosal immunoglobulins and B cells of teleost fish.

    abstract::As physical barriers that separate teleost fish from the external environment, mucosae are also active immunological sites that protect them against exposure to microbes and stressors. In mammals, the sites where antigens are sampled from mucosal surfaces and where stimulation of naïve T and B lymphocytes occurs are k...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章,评审


    authors: Salinas I,Zhang YA,Sunyer JO

    更新日期:2011-12-01 00:00:00

  • The PHD domain of the sea urchin RAG2 homolog, SpRAG2L, recognizes dimethylated lysine 4 in histone H3 tails.

    abstract::V(D)J recombination is a somatic gene rearrangement process that assembles antigen receptor genes from individual segments during lymphocyte development. The access of the RAG1/RAG2 recombinase to these gene segments is regulated at the level of chromatin modifications, in particular histone tail modifications. Trimet...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Wilson DR,Norton DD,Fugmann SD

    更新日期:2008-01-01 00:00:00

  • The oyster immunity.

    abstract::Oysters, the common name for a number of different bivalve molluscs, are the worldwide aquaculture species and also play vital roles in the function of ecosystem. As invertebrate, oysters have evolved an integrated, highly complex innate immune system to recognize and eliminate various invaders via an array of orchest...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章,评审


    authors: Wang L,Song X,Song L

    更新日期:2018-03-01 00:00:00

  • Evolution of IFN-λ in tetrapod vertebrates and its functional characterization in green anole lizard (Anolis carolinensis).

    abstract::IFN-λ (IFNL), i.e. type III IFN genes were found in a conserved gene locus in tetrapod vertebrates. But, a unique locus containing IFNL was found in avian. In turtle and crocodile, IFNL genes were distributed in these two separate loci. As revealed in phylogenetic trees, IFN-λs in these two different loci and other am...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Chen SN,Zhang XW,Li L,Ruan BY,Huang B,Huang WS,Zou PF,Fu JP,Zhao LJ,Li N,Nie P

    更新日期:2016-08-01 00:00:00

  • Serum amyloid A transcription in Atlantic salmon (Salmo salar L.) hepatocytes is enhanced by stimulation with macrophage factors, recombinant human IL-1 beta, IL-6 and TNF alpha or bacterial lipopolysaccharide.

    abstract::Serum amyloid A (A-SAA) has previously been reported to be an acute-phase protein in salmonids. Hepatocytes represent a major source of A-SAA in salmonids, but nothing is known about hepatocyte SAA synthesis in fish. In the present work, the expression of A-SAA transcripts in primary cultures of Atlantic salmon hepato...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Jørgensen JB,Lunde H,Jensen L,Whitehead AS,Robertsen B

    更新日期:2000-09-01 00:00:00

  • Exploring the relationships between amphibian (Xenopus laevis) myeloid cell subsets.

    abstract::The differentiation of distinct leukocyte subsets is governed by lineage-specific growth factors that elicit disparate expression of transcription factors and markers by the developing cell populations. For example, macrophages (Mφs) and granulocytes (Grns) arise from common granulocyte-macrophage progenitors in respo...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Yaparla A,Koubourli DV,Popovic M,Grayfer L

    更新日期:2020-12-01 00:00:00

  • The ontogeny of the porcine immune system.

    abstract::Cellular and humoral aspects of the immune response develop sequentially in the fetus. During the ontogeny, the pluripotent stem cells emerge and differentiate into all hematopoietic lineages. Basic questions including the identification of the first lympho-hematopoietic sites, the origin of T and B lymphocytes, the d...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章,评审


    authors: Sinkora M,Butler JE

    更新日期:2009-03-01 00:00:00

  • Molecular cloning of chicken interleukin-5 receptor α-chain and analysis of its binding specificity.

    abstract::Interaction between interleukin (IL)-5 and its receptor (IL-5R) is important for the regulation of immunity against worm infections, allergic reactions and B cell response in mammals. In this study, we identified a full-length cDNA encoding chicken IL-5R α-chain (chIL-5Rα). The deduced amino acid sequence showed 41-43...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Fukushima Y,Miyai T,Kumagae M,Horiuchi H,Furusawa S

    更新日期:2012-07-01 00:00:00

  • Transcriptional regulation of type I interferon gene expression by interferon regulatory factor-3 in Japanese flounder, Paralichthys olivaceus.

    abstract::Type I interferon (IFN) induces the antiviral response in innate immunity. The type I IFN gene cloned from Japanese flounder (Paralichthys olivaceus) has a length of 1189 bp and consisting of 5 exons and 4 introns. In a phylogenetic tree of type I IFNs, Japanese flounder grouped with other Acanthopterygii. To gain ins...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Ohtani M,Hikima J,Hwang SD,Morita T,Suzuki Y,Kato G,Kondo H,Hirono I,Jung TS,Aoki T

    更新日期:2012-04-01 00:00:00

  • Molecular cloning and characterization of novel cathelicidin-derived myeloid antimicrobial peptide from Phasianus colchicus.

    abstract::Cathelicidins were initially characterized as a family of antimicrobial peptides. Now it is clear that they fulfill several immune functions in addition to their antimicrobial activity. In the current work, three cDNA sequences encoding pheasant cathelicidins were cloned from a constructed bone marrow cDNA library of ...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Wang Y,Lu Z,Feng F,Zhu W,Guang H,Liu J,He W,Chi L,Li Z,Yu H

    更新日期:2011-03-01 00:00:00

  • Functional characterization of STATa/b genes encoding transcription factors from Branchiostoma belcheri.

    abstract::The signal transducer and activator of transcription (STAT), as an important transcription factor of the Janus kinase (JAK)-STAT signaling pathway, is pivotal for development and immunity and well documented in vertebrates. However, the STAT gene has not been reported in chordate amphioxus (Branchiostoma belcheri). In...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Cao Y,Fang T,Fan M,Wang L,Lv C,Xiaojun Song,Jin P,Ma F

    更新日期:2021-01-01 00:00:00

  • Functional studies on Calliphora vomitoria haemocyte subpopulations defined by lectin staining and density centrifugation.

    abstract::Haemocyte subpopulations of Calliphora vomitoria have been categorized by their surface staining properties using fluorescently labelled lectins, and their mobilities in Percoll density gradients. These methods of identification were exploited to determine the roles of these cell types in cellular defence reactions. S...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: McKenzie AN,Preston TM

    更新日期:1992-01-01 00:00:00

  • RNA-seq identifies integrin alpha of kuruma shrimp Marsupenaeus japonicus as a candidate molecular marker for phagocytic hemocytes.

    abstract::Phagocytosis is main cellular immunity, however, it is still unknown or debated upon which types of hemocyte contributes phagocytosis in penaeid shrimps. The hemocyte characterization in kuruma shrimp have been mainly performed based on its morphology by microscopic observation. Therefore, establishment of molecular m...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Koiwai K,Kondo H,Hirono I

    更新日期:2018-04-01 00:00:00

  • Microarray analyses reveal distinct roles for Rel proteins in the Drosophila immune response.

    abstract::The NF-kappaB group of transcription factors play an important role in mediating immune responses in organisms as diverse as insects and mammals. The fruit fly Drosophila melanogaster express three closely related NF-kappaB-like transcription factors: Dorsal, Dif, and Relish. To study their roles in vivo, we used micr...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Pal S,Wu J,Wu LP

    更新日期:2008-01-01 00:00:00

  • In vitro organ culture of embryonic bursa of Fabricius.

    abstract::An in vitro method for organ culture of embryonic bursa of Fabricius is presented. It is shown that bursa cells proliferate in in vitro culture as evidenced by [3H]-thymidine incorporation. We assessed the expression of B-cell alloantigen (Bu-la and Bu-lb), class I (B-F) and class II (B-L) antigens of chicken major hi...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Nowak JS,Vainio O,Lassila O

    更新日期:1990-04-01 00:00:00

  • A class B scavenger receptor mediates antimicrobial peptide secretion and phagocytosis in Chinese mitten crab (Eriocheir sinensis).

    abstract::Scavenger receptors (SRs) are pattern recognition receptors (PRRs) vital for innate immunity. As well as their importance in immune recognition, microbe phagocytosis, and the clearance of modified endogenous molecules, they also activate downstream immune responses as co-receptors. In the current study, we identified ...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Tang M,Li X,Yang L,Wang Q,Li W

    更新日期:2020-02-01 00:00:00

  • The production of toxic oxygen metabolites by hemocytes of different snail species.

    abstract::The phagocytic hemocytes of four snail species were investigated for their ability to generate reactive oxygen metabolites upon stimulation by foreign material. Hemocytes of the pond snail Lymnaea stagnalis and of the garden snail Helix aspersa showed a luminol-dependent chemiluminescence (CL) when they phagocytosed z...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Dikkeboom R,van der Knaap WP,van den Bovenkamp W,Tijnagel JM,Bayne CJ

    更新日期:1988-07-01 00:00:00

  • Sex-associated differences in the mitogenic responsiveness of snake blood lymphocytes.

    abstract::The blastogenic response of male and female snake (Psammophis sibilans) peripheral blood lymphocytes to concanavalin A, phytohaemagglutinin, and E. coli lipopolysaccharide was tested for putative sex-associated differences. Data obtained suggest that normal female blood lymphocytes respond relatively vigorous in compa...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Saad AH

    更新日期:1989-07-01 00:00:00

  • Bovine WC1(-) gammadeltaT cells incubated with IL-15 express the natural cytotoxicity receptor CD335 (NKp46) and produce IFN-gamma in response to exogenous IL-12 and IL-18.

    abstract::The gammadeltaT cells of ruminants are believed to participate in innate immunity and have been described with regulatory, inflammatory and cytotoxic functions. Here we describe a subset of CD3(+) TcR1(+) WC1(-)gammadeltaT cells expressing CD335 (NKp46), classically associated with CD3(-) natural killer (NK) cells, as...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Johnson WC,Bastos RG,Davis WC,Goff WL

    更新日期:2008-01-01 00:00:00

  • Chemotaxis of nurse shark leukocytes.

    abstract::Studies were conducted to determine the ability of leukocytes from the nurse shark to migrate in an in vitro micropore filter chemotaxis assay and to determine optimal assay conditions and suitable attractants for such an assay. A migratory response was seen with several attractants: activated rat serum, activated sha...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Obenauf SD,Smith SH

    更新日期:1985-04-01 00:00:00

  • Molecular and functional characterization of a mannose-binding lectin/ficolin-associated protein (MAp44) from Nile tilapia (Oreochromis niloticus) involved in the immune response to bacterial infection.

    abstract::The lectin pathway of the complement system has a pivotal role in the defense against infectious organisms. Mannose-binding lectin/ficolin-associated protein (MAp44), a multifunctional complement regulator, regulates the complement activation by competing with MASP-1, MASP-2 and MASP-3 for MBL and ficolin binding site...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Mu L,Wu H,Han K,Wu L,Bian X,Li B,Guo Z,Yin X,Ye J

    更新日期:2019-12-01 00:00:00