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In situ lymphocyte apoptosis in larval Xenopus laevis, the South African clawed toad.

Abstract：

:During Anuran metamorphosis larval structures regress, adult structures form anew and impaired T cell immune functions are noted, as are alterations in endogenous glucocorticoid titers. In situ histological data, after staining for DNA fragmentation, reveal patterns of lymphocyte suicide in the thymus and spleen of non-antigenically challenged, laboratory bred, developing larvae, that do not correlate with either impaired immune functions or plasma glucocorticoid titers. Apoptotic levels in the thymus are high in premetamorphic stages, low during prometamorphosis and high again, after metamorphic climax, reflecting a periodic removal of thymocytes. Lymphocytic apoptosis in the spleen is low during premetamorphosis, rises in prometamorphic stages, principally within the red pulp, reaching a peak at climax, before declining as metamorphosis is completed.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Grant P,Clothier RH,Johnson RO,Ruben LN

doi

10.1016/s0145-305x(97)00057-8

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

449-55

issue

4

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(97)00057-8

journal_volume

22

pub_type

杂志文章

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