Abstract:
:Dengue virus has become one of the most important arboviral pathogens affecting the world today. The virus is transmitted among humans by the mosquitoes Aedes aegypti and Ae. albopictus. Like other vector-borne pathogens, this virus encounters innate immune defenses within the mosquito vector that limit infection. We have previously demonstrated the involvement of the Toll pathway in the anti-dengue defense at 7 days after infection. In the present study, we have investigated the activity of this immune signaling pathway against different dengue virus serotypes at the early stages of infection in laboratory and field-derived mosquito strains. Our studies corroborate the importance of the Toll pathway in the anti-dengue defense repertoire at 3 days after an infectious blood meal, when new virions are released from the midgut for dissemination and infection of other mosquito tissues. These immune defenses are furthermore conserved among different Ae. aegypti strains and can act against a broad range of dengue virus serotypes.
journal_name
Dev Comp Immunoljournal_title
Developmental and comparative immunologyauthors
Ramirez JL,Dimopoulos Gdoi
10.1016/j.dci.2010.01.006subject
Has Abstractpub_date
2010-06-01 00:00:00pages
625-9issue
6eissn
0145-305Xissn
1879-0089pii
S0145-305X(10)00019-4journal_volume
34pub_type
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