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Conserved inhibitory role of teleost SOCS-1s in IFN signaling pathways.

Abstract：

:The suppressor of cytokine signaling 1 (SOCS-1) protein is a critical regulator in the immune systems of humans and mammals, which functions classically as an inhibitor of the IFN signaling pathways. However, data on functional characterisation of SOCS-1 in ancient vertebrates are limited. In this study, we report the function of teleost SOCS-1s in IFN signaling in fish models (zebrafish and Tetraodon) and human cells. Structurally, teleost SOCS-1s share conserved functional domains with their mammalian counterparts. Functionally, teleost SOCS-1s could be significantly induced upon stimulation with IFN stimulants and zebrafish IFNφ1. Overexpression of teleost SOCS-1s could dramatically suppress IFNφ1-induced Mx, Viperin and PKZ activation in zebrafish, and IFN-induced ISG15 activation in HeLa cells. Furthermore, a SOCS-1 variant that lacks the KIR domain was also characterised. This study demonstrates the conserved negative regulatory role of teleost SOCS-1s in IFN signaling pathways, providing perspective into the functional conservation of SOCS-1 proteins during evolution.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Nie L,Xiong R,Zhang YS,Zhu LY,Shao JZ,Xiang LX

doi

10.1016/j.dci.2013.10.007

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

23-9

issue

1

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(13)00298-X

journal_volume

43

pub_type

杂志文章

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