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Interferon γ and interleukin 10 responses in immunocompetent and immunosuppressed New Zealand White rabbits naturally infected with Encephalitozoon cuniculi.

Abstract：

:Levels of interferon (IFN)-γ and interleukin (IL)-10 were measured in the serum of immunocompetent and immunosuppressed New Zealand White rabbits naturally infected with Encephalitozoon cuniculi. IFN-γ levels were elevated in infected rabbits, and a synergic effect was observed in animals treated with the immunosuppressive agent dexamethasone (Dex). The role of IL-10 in infected rabbits remains unclear, as IL-10 levels were similar to those of negative controls. Dex appeared to exhibit a proinflammatory effect, as IFN-γ levels were elevated in infected immunosuppressed rabbits. Similarly, Dex exhibited a synergic effect in infected immunosuppressed rabbits, as evidenced by the elevation in IFN-γ production. These data indicate that the immune response to this glucocorticoid should be considered in the design of future animal model studies of immunosuppression.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Rodríguez-Tovar LE,Castillo-Velázquez U,Arce-Mendoza AY,Nevárez-Garza AM,Zarate-Ramos JJ,Hernández-Vidal G,Rodríguez-Ramírez HG,Trejo-Chávez A

doi

10.1016/j.dci.2016.05.003

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

82-8

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(16)30148-3

journal_volume

62

pub_type

杂志文章

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