当前位置： SCI文献检索 > DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY期刊下所有文献 > Molecular cloning and expression analysis of mannose receptor C type 1 in grass carp (Ctenopharyngodon idella).

Molecular cloning and expression analysis of mannose receptor C type 1 in grass carp (Ctenopharyngodon idella).

Abstract：

:Mannose receptor C type 1 (MRC1) is a pattern-recognition receptor (PRR) which plays a significant role in immune responses. Much work on MRC1 has been done in mammals and birds while little in fish. In this study, we cloned and characterized MRC1 in grass carp (gcMR). The full-length gcMR contained 5291bp encoding a putative protein of 1432 amino acids. The predicted amino acid sequences showed that gcMR contained a signal peptide, a cysteine-rich (CR) domain, a fibronectin type II (FN II) domain, eight C-type lectin-like domains (CTLDs), a transmembrane domain and a short cytoplasmic domain. gcMR were constitutively expressed in different organs with the higher expression in spleen and head kidney. During embryonic development, gcMR transcript levels were highest at cleavage stage. The up-regulation expression of gcMR, IL-1β and TNF-α in liver, spleen, head kidney and intestine after Aeromonas hydrophila infection indicating it involved in innate immune regulation during bacterial infections.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Wang L,Liu L,Zhou Y,Zhao X,Xi M,Wei S,Fang R,Ji W,Chen N,Gu Z,Liu X,Wang W,Asim M,Liu X,Lin L

doi

10.1016/j.dci.2013.10.006

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

54-8

issue

1

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(13)00297-8

journal_volume

43

pub_type

杂志文章

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