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Porcine CD27: identification, expression and functional aspects in lymphocyte subsets in swine.

Abstract：

:Up to now for Swine Workshop Cluster 2 (SWC2) the orthologous human CD molecule was unknown. By use of the SWC2-specific mAb b30c7 and a retroviral cDNA expression library derived from stimulated porcine peripheral blood mononuclear cells we could identify SWC2 as porcine CD27. Phenotypic analyses of lymphocytes isolated from blood and lymphatic organs revealed that mature T cells in thymus and T cells in the periphery with a naïve phenotype were CD27(+). However, within CD8α(+) T helper and CD8α(+) γδ T cells also CD27(-) cells were present, indicating a down-regulation after antigen contact in vivo. B cells lacked CD27 expression, whereas NK cells expressed intermediate levels. Furthermore, plate-bound mAb b30c7 showed a costimulatory capacity on CD3-activated T cells for proliferation, IFN-γ and TNF-α production. Hence, our data indicate an important role of porcine CD27 for T-cell differentiation and activation as described for humans and mice.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Reutner K,Leitner J,Essler SE,Witter K,Patzl M,Steinberger P,Saalmüller A,Gerner W

doi

10.1016/j.dci.2012.06.011

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

321-31

issue

2

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(12)00156-5

journal_volume

38

pub_type

杂志文章

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