Abstract:
:Surfactant Protein A (SP-A) is a collagenous C-type lectin (collectin) that plays an important role in the early stage of the host immune response. In chicken, SP-A (cSP-A) is expressed as a 26 kDa glycosylated protein in the lung. Using immunohistochemistry, cSP-A protein was detected mainly in the lung lining fluid covering the parabronchial epithelia. Specific cSP-A producing epithelial cells, resembling mammalian type II cells, were identified in the parabronchi. Gene expression of cSP-A markedly increased from embryonic day 14 onwards until the time of hatch, comparable to the SP-A homologue chicken lung lectin, while mannan binding lectin and collectins CL-L1 and CL-K1 only showed slightly changed expression during development. cSP-A protein could be detected as early as ED 18 in lung tissue using Western blotting, and expression increased steadily until day 28 post-hatch. Our observations are a first step towards understanding the role of this protein in vivo.
journal_name
Dev Comp Immunoljournal_title
Developmental and comparative immunologyauthors
Zhang W,Cuperus T,van Dijk A,Skjødt K,Hansen S,Haagsman HP,Veldhuizen EJdoi
10.1016/j.dci.2016.03.010subject
Has Abstractpub_date
2016-08-01 00:00:00pages
80-7eissn
0145-305Xissn
1879-0089pii
S0145-305X(16)30090-8journal_volume
61pub_type
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