当前位置： SCI文献检索 > DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY期刊下所有文献 > SIKE of black carp is a substrate of TBK1 and suppresses TBK1-mediated antiviral signaling.

SIKE of black carp is a substrate of TBK1 and suppresses TBK1-mediated antiviral signaling.

Abstract：

:RIG-I like receptor (RLR) signaling functions importantly in host innate immune response against RNA virus, which is tightly regulated by a number of mechanisms to prevent aberrant interferon production. The suppressor of IKKε (SIKE) has been identified as a suppressor of IKKε and TBK1, which are key components of RLR signaling. In this study, SIKE homologue (bcSIKE) of black carp (Mylopharyngodon piceus) has been cloned and characterized. The transcription of bcSIKE varied in host cells in response to the stimulation of LPS, poly (I:C) and viruses. bcSIKE migrated around 27 KDa in immunoblot assay and distributed in both cytoplasm and nucleus of host cell in immunofluorescent (IF) staining test. bcSIKE showed no IFN-inducing ability in reporter assay and EPC cells expressing bcSIKE showed no enhanced antiviral ability against either grass carp reovirus (GCRV) or spring viremia of carp virus (SVCV). However, bcSIKE obviously dampened the IFN-inducing ability of RLR signaling members in reporter assay when bcSIKE was co-expressed with these molecules in EPC cells. The association between bcSIKE and bcTBK1 has been identified through IF and co-immunoprecipitation (co-IP) assay. The plaque assay demonstrated clearly that bcTBK1-mediated antiviral activity in EPC cells against both GCRV and SVCV was down regulated by bcSIKE. All the data generated in this paper support the conclusion that bcSIKE interacts with bcTBK1 and inhibits bcTBK1-mediated antiviral signaling during host innate immune activation, which is reported in teleost for the first time.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Li J,Yan C,Liu J,Yan J,Feng H

doi

10.1016/j.dci.2018.09.016

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

157-164

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(18)30444-0

journal_volume

90

pub_type

杂志文章

相关文献

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY文献大全
  • Autophagy induced by infectious hematopoietic necrosis virus inhibits intracellular viral replication and extracellular viral yields in epithelioma papulosum cyprini cell line.

    abstract：:Infectious hematopoietic necrosis virus (IHNV) is a common pathogen that causes severe disease in the salmonid aquaculture industry. Recent work demonstrated that autophagy plays an important role in pathogen invasion by activating innate and adaptive immunity. This study investigated the relationship between IHNV and...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2017.07.025

    authors： Zhao JZ,Xu LM,Liu M,Zhang ZY,Yin JS,Liu HB,Lu TY

    更新日期：2017-12-01 00:00:00

  • Immunological milestones in ontogeny.

    abstract：:Age-equivalence shows that certain differentiative events and the onset of various types of immunocompetence follow the same sequence in all species as lymphocytes emerge during development. ...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0145-305x(78)80003-2

    authors： Solomom JB

    更新日期：1978-07-01 00:00:00

  • IL-22 is a key player in the regulation of inflammation in fish and involves innate immune cells and PI3K signaling.

    abstract：:IL-22 plays a role in various disorders in mammals, including mucosal-associated infections and inflammatory diseases. No functional IL-22 studies have been conducted on non-mammals to date. In this study, recombinant IL-22 (rIL-22) from turbot was produced to investigate its effects as a bioactive molecule. The expre...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2013.08.021

    authors： Costa MM,Saraceni PR,Forn-Cuní G,Dios S,Romero A,Figueras A,Novoa B

    更新日期：2013-12-01 00:00:00

  • Developmental regulation of chicken surfactant protein A and its localization in lung.

    abstract：:Surfactant Protein A (SP-A) is a collagenous C-type lectin (collectin) that plays an important role in the early stage of the host immune response. In chicken, SP-A (cSP-A) is expressed as a 26 kDa glycosylated protein in the lung. Using immunohistochemistry, cSP-A protein was detected mainly in the lung lining fluid ...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2016.03.010

    authors： Zhang W,Cuperus T,van Dijk A,Skjødt K,Hansen S,Haagsman HP,Veldhuizen EJ

    更新日期：2016-08-01 00:00:00

  • Molecular cloning and characterization of interferon regulatory factor 1 (IRF-1), IRF-2 and IRF-5 in the chondrostean paddlefish Polyodon spathula and their phylogenetic importance in the Osteichthyes.

    abstract：:The interferon regulatory factor (IRF) with its 10 members is a very important gene family related to innate immunity. Currently, most fish IRFs reported are from bony fish (teleosts). Cloning and sequencing of IRFs from chondrosteans, the so-called "ancient fish" including sturgeon, paddlefish, bichir and gar, are ab...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2011.06.003

    authors： Xiaoni G,Zhuo C,Xuzhen W,Dengqiang W,Xinwen C

    更新日期：2012-01-01 00:00:00

  • Heat shock 70 kDa protein cognate 5 involved in WSSV toleration of Litopenaeus vannamei.

    abstract：:The expression levels of 97 unigenes encoding heat shock proteins of Litopenaeus vannamei was scanned, and ten of them were significantly induced by white spot syndrome virus (WSSV). Among these genes, heat shock 70 kDa protein cognate 5 (LvHSC70-5) was upregulated to the highest extent and subjected to further studie...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2017.02.003

    authors： Yuan K,Yuan FH,He HH,Bi HT,Weng SP,He JG,Chen YH

    更新日期：2017-07-01 00:00:00

  • Effects of Trichobilharzia ocellata on hemocytes of Lymnaea stagnalis.

    abstract：:We analyzed the effects of infection with Trichobilharzia ocellata on hemocytes of its snail host, Lymnaea stagnalis, and correlated them with successive stages of parasite development. Circulating hemocytes were studied at 0, 2, 4, 6, and 8 weeks post exposure (p.e.) with respect to cell number, distribution of subpo...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(91)90001-f

    authors： Amen RI,Tijnagel JM,van der Knaap WP,Meuleman EA,de Lange-de Klerk ES,Sminia T

    更新日期：1991-04-01 00:00:00

  • The expression of CD8α discriminates distinct T cell subsets in teleost fish.

    abstract：:CD8, belonging to the TCR complex, is the main marker molecule of CTLs. Although CD8 genes have been detected in many fish species, the analysis of teleost CD8+ cells has been limited because of the lack of antibodies. Using newly established mAbs against rainbow trout CD8α, we found high ratios of CD8α+ cells in trou...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2011.02.008

    authors： Takizawa F,Dijkstra JM,Kotterba P,Korytář T,Kock H,Köllner B,Jaureguiberry B,Nakanishi T,Fischer U

    更新日期：2011-07-01 00:00:00

  • Antimicrobial peptide defenses against chytridiomycosis, an emerging infectious disease of amphibian populations.

    abstract：:Chytridiomycosis, an emerging infectious disease (EID) of the skin caused by the chytrid fungus, Batrachochytrium dendrobatidis, has been linked with continuing amphibian population declines in the western USA, Central America, Europe, Africa, and Australia. Genetic analysis suggests that B. dendrobatidis is a recentl...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2004.11.004

    authors： Rollins-Smith LA,Conlon JM

    更新日期：2005-01-01 00:00:00

  • Gene expression study in Bathymodiolus azoricus populations from three North Atlantic hydrothermal vent sites.

    abstract：:The deep-sea hydrothermal vents are known as harsh environments, abundant in animal diversity surrounded by fluids with specific physiological and chemical composition. Bathymodiolus azoricus mussels are endemic species dwelling at hydrothermal vent sites and at distinct depth ranges. Mussels from Menez Gwen (MG), Luc...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2019.05.001

    authors： Martins E,Bettencourt R

    更新日期：2019-10-01 00:00:00

  • Retrospection to discovery of bursal function and recognition of avian dendritic cells; past and present.

    abstract：:In 1954 the discovery of bursal function was one of the major contributions to the formation of the T and B cell concept of immunology. In 1978 the avian dendritic cells; bursal secretory dendritic cell (BSDC) and follicular dendritic cell (FDC) in the cecal tonsil were recognized. In 1982 the interdigitating dendriti...

    journal_title：Developmental and comparative immunology

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.dci.2013.03.007

    authors： Oláh I,Nagy N

    更新日期：2013-11-01 00:00:00

  • Immunopathogenesis of haemorrhagic enteritis virus (HEV) in turkeys.

    abstract：:Infection of turkeys with the haemorrhagic enteritis virus (HEV), a type II avian adenovirus, results in varying rates of morbidity and mortality. The disease is characterised by splenomegaly, intestinal haemorrhage, sudden death and immunosuppression. The mechanisms of HEV immunopathogenesis and immunosuppression are...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0145-305x(99)00075-0

    authors： Rautenschlein S,Sharma JM

    更新日期：2000-03-01 00:00:00

  • Snail defence responses to parasite infection: The Lymnaea stagnalis-Trichobilharzia szidati model.

    abstract：:Lymnaea stagnalis is a common freshwater gastropod. Importantly, the snail serves as the intermediate host for more than one hundred species of digenetic trematodes, including the avian schistosome Trichobilharzia szidati, a causative agent of cercarial dermatitis in humans. Infection of L. stagnalis by T. szidati ini...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2019.103464

    authors： Skála V,Walker AJ,Horák P

    更新日期：2020-01-01 00:00:00

  • Molecular cloning and characterisation of chicken IL-18 binding protein.

    abstract：:The human IL-1 receptor family is comprised of 11 membrane bound or soluble receptors and the IL-18 binding protein (IL-18BP). These receptors are dispersed across seven genomic loci, with the majority at a single locus. Direct orthologues were identified in the chicken at conserved genomic loci; however, the IL-18BP ...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2020.103850

    authors： Gibson MS,Steyn A,Kealy D,Kaspers B,Fife MS

    更新日期：2021-01-01 00:00:00

  • The sensing pattern and antitoxic response of Crassostrea gigas against extracellular products of Vibrio splendidus.

    abstract：:Serious juvenile oyster disease induced by pathogenic Vibrio splendidus has resulted in tremendous economic loss, but the molecular mechanisms underlying this killing mechanism remain unclear. The resistance of adult oyster to V. splendidus or its virulence factors might provide a possible access to cognize the intera...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2019.103467

    authors： Wang W,Lv X,Liu Z,Song X,Yi Q,Wang L,Song L

    更新日期：2020-01-01 00:00:00

  • RNA-seq identifies integrin alpha of kuruma shrimp Marsupenaeus japonicus as a candidate molecular marker for phagocytic hemocytes.

    abstract：:Phagocytosis is main cellular immunity, however, it is still unknown or debated upon which types of hemocyte contributes phagocytosis in penaeid shrimps. The hemocyte characterization in kuruma shrimp have been mainly performed based on its morphology by microscopic observation. Therefore, establishment of molecular m...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2017.12.014

    authors： Koiwai K,Kondo H,Hirono I

    更新日期：2018-04-01 00:00:00

  • A class B scavenger receptor mediates antimicrobial peptide secretion and phagocytosis in Chinese mitten crab (Eriocheir sinensis).

    abstract：:Scavenger receptors (SRs) are pattern recognition receptors (PRRs) vital for innate immunity. As well as their importance in immune recognition, microbe phagocytosis, and the clearance of modified endogenous molecules, they also activate downstream immune responses as co-receptors. In the current study, we identified ...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2019.103496

    authors： Tang M,Li X,Yang L,Wang Q,Li W

    更新日期：2020-02-01 00:00:00

  • Antigenic profiles of endothelial and hemopoietic lineages in murine intraembryonic hemogenic sites.

    abstract：:Two hemogenic sites are present in mouse embryos before the onset of fetal liver hemopoiesis. While the yolk sac provides for immediate erythropoiesis, an intraembryonic region encompassing the dorsal aorta produces definitive hematopoietic stem cells, as shown experimentally. At early developmental stages this region...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(98)00006-8

    authors： Garcia-Porrero JA,Manaia A,Jimeno J,Lasky LL,Dieterlen-Lièvre F,Godin IE

    更新日期：1998-05-01 00:00:00

  • Tissue-specific expression and molecular modeling of cytosolic manganese superoxide dismutases from the white shrimp Litopenaeus vannamei.

    abstract：:Manganese superoxide dismutases (MnSODs) are usually mitochondrial enzymes, although there are few examples of cytosolic MnSODs (cMnSOD). We have previously characterized a cMnSOD cDNA from Litopenaeus vannamei hemocytes, and to obtain new insights into the tissue specific expression and the protein structure, we char...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2006.11.007

    authors： Gómez-Anduro GA,Sotelo-Mundo RR,Muhlia-Almazán A,Yepiz-Plascencia G

    更新日期：2007-01-01 00:00:00

  • microRNA-589-5p modulates the expression of hemocyanin as part of the anti-WSSV immune response in Litopenaeus vannamei.

    abstract：:The respiratory glycoprotein, hemocyanin (HMC) has multiple immune-related functions, including antiviral activity. In this study, in silico methods were used to predict seven miRNAs targeting Litopenaeus vannamei HMC (LvHMC), out of which miR-589-5p was selected for further investigation because of its role in immune...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2020.103642

    authors： Bao S,Zheng Z,Aweya JJ,Yao D,Li S,Sun C,Hong Y,Zhang Y

    更新日期：2020-06-01 00:00:00

  • The essential role of clathrin-mediated endocytosis in yellow head virus propagation in the black tiger shrimp Penaeus monodon.

    abstract：:Yellow head virus (YHV) is one of the most widespread viruses seriously affecting black tiger shrimp (Penaeus monodon) cultivation. A previous microarray study demonstrated that clathrin coat assembly protein 17 (AP17) was significantly up-regulated after YHV infection (Pongsomboon et al., 2011). Clathrin coat AP17 is...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2013.11.017

    authors： Jatuyosporn T,Supungul P,Tassanakajon A,Krusong K

    更新日期：2014-05-01 00:00:00

  • Genomic organization and differential expression of channel catfish MHC class I genes.

    abstract：:Two clones, designated Icpu-UA/3 and Icpu-UA/26, were isolated from a genomic library prepared from a single homozygous gynogenetic channel catfish. Sequence analysis showed that each clone encoded a gene product containing features conserved among MHC class I molecules. The genomic organization of both clones indicat...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(01)00017-9

    authors： Antao AB,Wilson M,Wang J,Bengtén E,Miller NW,Clem LW,Chinchar VG

    更新日期：2001-09-01 00:00:00

  • Transcriptome analysis of hagfish leukocytes: a framework for understanding the immune system of jawless fishes.

    abstract：:Jawless fishes occupy a critical phylogenetic position in understanding the origin of the adaptive immune system. Here, we performed large-scale expressed sequence tag analysis of leukocytes isolated from the inshore hagfish Eptatretus burgeri. Although we found many immunity-related genes such as those involved in ly...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2004.04.005

    authors： Suzuki T,Shin-I T,Kohara Y,Kasahara M

    更新日期：2004-08-01 00:00:00

  • The novel six LIM and one PET domain-containing protein Lmpt is involved in the immune response through activation of the NF-κB signalling pathway in the crustacean, Macrobrachium nipponense.

    abstract：:The four-and-a-half LIM-only protein family of transcription co-factors participates in various cellular processes, such as cell proliferation, cell differentiation, apoptosis, cell adhesion, migration, transcription and signal transduction. However, the knowledge of the structural characteristics and immune functions...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2020.103948

    authors： Xu L,Zhou X,Wang P,Jin Q,Zhu T,Chen M,Xu H

    更新日期：2021-03-01 00:00:00

  • Cell type-specific differences in β-glucan recognition and signalling in porcine innate immune cells.

    abstract：:β-glucans exert receptor-mediated immunomodulating activities, including oxidative burst activity and cytokine secretion. The role of the β-glucan receptors dectin-1 and complement receptor 3 (CR3) in the response of immune cells towards β-glucans is still unresolved. Dectin-1 is considered as the main β-glucan recept...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2014.10.005

    authors： Baert K,Sonck E,Goddeeris BM,Devriendt B,Cox E

    更新日期：2015-01-01 00:00:00

  • Serum amyloid A transcription in Atlantic salmon (Salmo salar L.) hepatocytes is enhanced by stimulation with macrophage factors, recombinant human IL-1 beta, IL-6 and TNF alpha or bacterial lipopolysaccharide.

    abstract：:Serum amyloid A (A-SAA) has previously been reported to be an acute-phase protein in salmonids. Hepatocytes represent a major source of A-SAA in salmonids, but nothing is known about hepatocyte SAA synthesis in fish. In the present work, the expression of A-SAA transcripts in primary cultures of Atlantic salmon hepato...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(00)00022-7

    authors： Jørgensen JB,Lunde H,Jensen L,Whitehead AS,Robertsen B

    更新日期：2000-09-01 00:00:00

  • Epitopes for chicken monoclonal antibodies in spleens of selected Japanese quail lines.

    abstract：:A line of Japanese quail selected for high plasma cholesterol is highly susceptible to diet-induced atherosclerosis. Lymphocyte epitopes recognized by mouse anti-chicken monoclonal antibodies (c-mAb), TCR-1, TCR-2, TCR-3. CD-3, CD-4, CD-8, and BU-1a/b were reacted with spleens from quail selected for high (HL) and low...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(99)00033-6

    authors： Lovitt HL,Siegel HS,Weinstock D,Marks HL

    更新日期：1999-09-01 00:00:00

  • The immune system of sea bass, Dicentrarchus labrax, reared in aquaculture.

    abstract：:The sea bass Dicentrarchus labrax is one the most important seawater fish species of south Europe and Mediterranean aquaculture, and studies on its immune system are important for both scientific and applied purposes. In this paper, we summarise the results obtained in studies of the immune system in this species, and...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0145-305x(01)00057-x

    authors： Scapigliati G,Romano N,Buonocore F,Picchietti S,Baldassini MR,Prugnoli D,Galice A,Meloni S,Secombes CJ,Mazzini M,Abelli L

    更新日期：2002-03-01 00:00:00

  • Comparison of suppressor cells obtained from tumor-allosensitized adult and untreated neonatal mice.

    abstract：:Splenic suppressor cells from neonatal ("intrinsic") and adult (tumor-allosensitized) mice were compared. Both are non-antigen specific and non-H-2 restricted, and are Ly1+2+, I-J+, QA2+ T-cells. Injection of adult peritoneal exudate cells into neonates or adult tumor-allosensitized mice decreases suppressor cell acti...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(85)90066-7

    authors： Argyris BF

    更新日期：1985-01-01 00:00:00

  • High doses of sodium ascorbate act as a prooxidant and protect gnotobiotic brine shrimp larvae (Artemia franciscana) against Vibrio harveyi infection coinciding with heat shock protein 70 activation.

    abstract：:Ascorbate is an essential nutrient commonly regarded as an antioxidant. In this study, using axenic brine shrimp and pathogenic strain Vibrio harveyi as the host-pathogen model, we confirmed that pretreatment of sodium ascorbate (NaAs), at an optimum concentration, was a prooxidant by generation of hydrogen peroxide, ...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2018.11.007

    authors： Han B,Kaur VI,Baruah K,Nguyen VD,Bossier P

    更新日期：2019-03-01 00:00:00