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Alternate forms of MHC class II-associated invariant chain are not produced by alternative splicing in rainbow trout (Oncorhynchus mykiss) but are encoded by separate genes.

Abstract：

:A major limiting factor in understanding teleost major histocompatibility receptor function is the lack of knowledge about antigen presentation accessory molecules. We report here two cDNA clones encoding teleost versions of invariant chain and one encoding a related protein that may play a protease inhibition role in antigen presentation. The two invariant chain equivalents are similar to each other where they overlap, but differ in the presence or absence of a thyroglobulin domain. This domain is added to tetrapod invariant chain protein by alternative splicing but there was no evidence of alternative splicing of the two trout genes. Southern blotting confirmed that all three trout cDNAs are derived from single copy genes and Northern blotting indicated that they are expressed in antigen tissues. Thus the encoded proteins are probably involved in antigen presentation, but their expression is probably regulated in a manner different from tetrapods.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Fujiki K,Smith CM,Liu L,Sundick RS,Dixon B

doi

10.1016/s0145-305x(02)00119-2

keywords:

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

377-91

issue

5

eissn

0145-305X

issn

1879-0089

pii

S0145305X02001192

journal_volume

27

pub_type

杂志文章

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