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An alternative internal splicing site defines new Ikaros isoforms in Pleurodeles waltl.

Abstract：

:The Ikaros gene encodes a family of transcription factors which plays a crucial role in hematopoiesis. To improve our knowledge about the immune system of Pleurodeles waltl, we sequenced the cDNA coding for the Ik-1 isoform of that salamander and analyzed its tissue expression by semi-quantitative RT-PCR. Ikaros transcripts are abundant in the thymus and the spleen, thereby confirming that these organs are, respectively, the primary and secondary lymphoid tissues of Pleurodeles. Analysis of the isoforms produced by this animal revealed two isoforms characteristic of amphibians in which an alternative internal splicing site deletes the 3' half of exon 3 which interestingly comprises the first Zn finger of Ikaros. Ikaros transcripts were found at the earliest stages of development of Pleurodeles indicating that Ikaros has a function at the very early lymphopoietic stages. Moreover, the presence of Ikaros transcripts in spermatozoa suggests that this protein could have another and yet unknown function.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Boudarra N,Frippiat C,Dournon C,Frippiat JP

doi

10.1016/s0145-305x(02)00014-9

keywords:

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

659-73

issue

7

eissn

0145-305X

issn

1879-0089

pii

S0145305X02000149

journal_volume

26

pub_type

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