Abstract：
:In a previous report we described the existence of two structural and antigenic variants of light chains in serum trout Igs, defined by mAbs 2H9 and 2A1. In this report, we analyse the cell distribution, the "in vitro" kinetics of production, and the ontogenic appearance of these two variants. Both variants were already present at day 8 before hatching and their kinetics of appearance correlated with that of total Ig, showing a peak around hatching. These mAbs stained two distinct lymphoid cell populations in the pronephros, mesonephros, spleen, and peripheral blood. Both mAbs reacted with approximately 1% of thymocytes. The ratio between these two cell populations (2A1+/2H9+) was about 2/1 in the lymphoid organs analysed. No differences were found between the profiles of the "in vitro" production of these variants in pronephric cell cultures stimulated with LPS. In these cultures, the 2A1 and 2H9 Igs together accounted for 10-70% of the total trout Ig produced, suggesting the existence of at least one additional L chain variant.
journal_name
Dev Comp Immunoljournal_title
Developmental and comparative immunologyauthors
Sánchez C,Alvarez A,Castillo A,Zapata A,Villena A,Domínguez Jdoi
10.1016/0145-305x(94)00058-nsubject
Has Abstractpub_date
1995-01-01 00:00:00pages
79-86issue
1eissn
0145-305Xissn
1879-0089pii
0145305X9400058Njournal_volume
19pub_type
杂志文章abstract：:The Ikaros gene encodes a family of transcription factors which plays a crucial role in hematopoiesis. To improve our knowledge about the immune system of Pleurodeles waltl, we sequenced the cDNA coding for the Ik-1 isoform of that salamander and analyzed its tissue expression by semi-quantitative RT-PCR. Ikaros trans...
journal_title：Developmental and comparative immunology
pub_type： 杂志文章
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更新日期：2002-09-01 00:00:00
abstract：:The full length coding sequence of the cattle transcription factor p65 was isolated and cloned. The cloned bovine p65 was expressed in mammalian cells, and it induced the NF-kappaB-specific luciferase reporter gene expression. Using gel retardation techniques, we demonstrated that the cloned bovine p65 bound to the co...
journal_title：Developmental and comparative immunology
pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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journal_title：Developmental and comparative immunology
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journal_title：Developmental and comparative immunology
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journal_title：Developmental and comparative immunology
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journal_title：Developmental and comparative immunology
pub_type： 杂志文章,评审
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更新日期：2014-04-01 00:00:00
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journal_title：Developmental and comparative immunology
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更新日期：2009-05-01 00:00:00
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journal_title：Developmental and comparative immunology
pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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journal_title：Developmental and comparative immunology
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更新日期：2004-01-01 00:00:00
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journal_title：Developmental and comparative immunology
pub_type： 杂志文章
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更新日期：1993-01-01 00:00:00
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journal_title：Developmental and comparative immunology
pub_type： 杂志文章,评审
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更新日期：2013-07-01 00:00:00
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journal_title：Developmental and comparative immunology
pub_type： 杂志文章
doi：10.1016/j.dci.2011.03.001
更新日期：2011-08-01 00:00:00
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journal_title：Developmental and comparative immunology
pub_type： 杂志文章
doi：10.1016/0145-305x(86)90027-3
更新日期：1986-07-01 00:00:00
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journal_title：Developmental and comparative immunology
pub_type： 杂志文章
doi：10.1016/j.dci.2013.10.007
更新日期：2014-03-01 00:00:00
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journal_title：Developmental and comparative immunology
pub_type： 杂志文章
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更新日期：2010-08-01 00:00:00
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journal_title：Developmental and comparative immunology
pub_type： 杂志文章
doi：10.1016/j.dci.2014.06.013
更新日期：2014-11-01 00:00:00
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journal_title：Developmental and comparative immunology
pub_type： 杂志文章,评审
doi：10.1016/s0145-305x(00)00008-2
更新日期：2000-07-01 00:00:00
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journal_title：Developmental and comparative immunology
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更新日期：2016-12-01 00:00:00
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journal_title：Developmental and comparative immunology
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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journal_title：Developmental and comparative immunology
pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
abstract：:Recently generated anti-Xenopus T cell monoclonal antibodies (mAbs) to the 120 kDa XTLA-1 determinant and against the putative CD5 and CD8 homologues, together with anti-IgM and anti-MHC class II mAbs, are used in dual colour flow cytometric experiments to characterize cell surface antigenic expression on lymphocytes ...
journal_title：Developmental and comparative immunology
pub_type： 杂志文章
doi：10.1016/0145-305x(95)00030-w
更新日期：1995-11-01 00:00:00
abstract：:C-type lectins (CTLs) are involved in cell-cell adhesion, recognition, and innate immunity in higher vertebrates, but little is known about CTLs in basal metazoans. The recent sequencing of the cnidarian Nematostella vectensis genome allowed us to explore the CTL-like gene family at the base of metazoan evolution. Six...
journal_title：Developmental and comparative immunology
pub_type： 杂志文章
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更新日期：2009-08-01 00:00:00
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journal_title：Developmental and comparative immunology
pub_type： 杂志文章
doi：10.1016/j.dci.2007.04.001
更新日期：2008-01-01 00:00:00
abstract：:Mx proteins are antiviral GTPases, which are induced by type I IFN and virus infection. Analysis of the Atlantic salmon genome revealed the presence of 9 Mx genes localized to three chromosomes. A cluster of three Mx genes (SsaMx1 - SsaMx3), which includes previously cloned Mx genes, is present on chromosome (Chr) 12....
journal_title：Developmental and comparative immunology
pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
abstract：:Immunity in insects has largely focused on responses towards bacteria and fungi, but recently the study of immune responses against viral infections has also received attention. In Lepidoptera, phagocytosis and encapsulation mediated by hemocytes, and apoptosis are part of the response against virus infection; however...
journal_title：Developmental and comparative immunology
pub_type： 杂志文章,评审
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更新日期：2008-01-01 00:00:00
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journal_title：Developmental and comparative immunology
pub_type： 杂志文章
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更新日期：1997-11-01 00:00:00
abstract：:Studies were conducted to determine the ability of leukocytes from the nurse shark to migrate in an in vitro micropore filter chemotaxis assay and to determine optimal assay conditions and suitable attractants for such an assay. A migratory response was seen with several attractants: activated rat serum, activated sha...
journal_title：Developmental and comparative immunology
pub_type： 杂志文章
doi：10.1016/0145-305x(85)90113-2
更新日期：1985-04-01 00:00:00
abstract：:VHSV-induced genes (VIGs) were first identified in rainbow trout (Oncorhynchus mykiss) and subsequently isolated in a variety of fish. Recent studies have shown that most VIGs have immunological functions against pathogenic infections. However, most research has focused on Vig1, such that our present understanding of ...
journal_title：Developmental and comparative immunology
pub_type： 杂志文章
doi：10.1016/j.dci.2013.10.014
更新日期：2014-03-01 00:00:00
abstract：:Allorecognition has been well-studied in the context of vertebrate adaptive immunity and recognition of the Major Histocompatibility Complex (MHC), which is the central event of vertebrate immune responses. Although allorecognition systems have been identified throughout the metazoa, recent results have shown that the...
journal_title：Developmental and comparative immunology
pub_type： 杂志文章,评审
doi：10.1016/j.dci.2014.03.014
更新日期：2015-01-01 00:00:00
