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EcVig, a novel grouper immune-gene associated with antiviral activity against NNV infection.

Abstract：

:VHSV-induced genes (VIGs) were first identified in rainbow trout (Oncorhynchus mykiss) and subsequently isolated in a variety of fish. Recent studies have shown that most VIGs have immunological functions against pathogenic infections. However, most research has focused on Vig1, such that our present understanding of these genes in other fish species remains limited. This study isolated a homologue of the uncharacterized O. mykiss Vig-B319 (EcVig) from orange-spotted grouper (Epinephelus coioides). Genomic organization suggests that four EcVig isoforms (EcVig A-D), are generated through alternative splicing. Due to the encoding of 2 immunoglobulin (Ig) domains, the EcVig protein can be considered a member of the immunoglobulin superfamily. The expression of EcVig increased 3 days after hatching (dph) and peaked at 9 dph. This pattern is similar to that displayed by EcMx, an important grouper antiviral gene. Additionally, a tissue tropism assay revealed that EcVig A is the major EcVig isoform present in the tissues considered by this study, with the expression of EcVig A exceeding that of EcVig B. We subsequently investigated whether EcVig expression was induced by the viral pathogen nervous necrosis virus (NNV) or the bacterial pathogen Vibrio anguillarum. Following injection with NNV, the expression levels of EcVig showed significant up-regulation. Conversely, a significant reduction was observed in EcVig expression in brain samples collected from V. anguillarum injected grouper. The overexpression of EcVig A suppressed the replication of NNV in grouper GF-1 cell lines, suggesting that EcVig is an important antiviral factor in the grouper immune responses.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Yeh YC,Hsu YJ,Chen YM,Lin HY,Yang HL,Chen TY,Wang HC

doi

10.1016/j.dci.2013.10.014

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

68-75

issue

1

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(13)00305-4

journal_volume

43

pub_type

杂志文章

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