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Panusin represents a new family of β-defensin-like peptides in invertebrates.

Abstract：

:Beta_defensin have been solely found in vertebrates until β-defensin-like peptides were described as transcript isoforms in two species of Panulirus genus. They were considered as putative antimicrobials since their biological activity have not been demonstrated. Here we purified and characterized a defensin-like peptide from the hemocytes of spiny lobster P. argus, hereafter named panusin. Structurally, panusin presents a cysteine-stabilized α/β motif, and is prone to form homodimers. Biological activity of panusin showed broad-spectrum antimicrobial activity, characterized for being strikingly salt-resistant. Panusin did not showed hemolytic activity but was demonstrated its binding capacity to different lipid membrane models, indicating amphipathicity of β-sheet core as driving force for its antimicrobial activity. Panusin is considered a new kind of arthropod defensin which share structural and biological features with beta-defensin from vertebrates. The presence of beta-defensin like peptides in crustacean might suggest the emergence of the evolutionary relationship of β-defensins from vertebrates.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Montero-Alejo V,Corzo G,Porro-Suardíaz J,Pardo-Ruiz Z,Perera E,Rodríguez-Viera L,Sánchez-Díaz G,Hernández-Rodríguez EW,Álvarez C,Peigneur S,Tytgat J,Perdomo-Morales R

doi

10.1016/j.dci.2016.09.002

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

310-321

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(16)30274-9

journal_volume

67

pub_type

杂志文章

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