Lipopolysaccharide activates the sea urchin immune system.


:Profilin is a small, actin-binding protein that functions at the intersection of signal transduction and cytoskeletal modifications. Increases in the number of profilin messages per cell correlate with sea urchin coelomocytes activation in response to injury. Here we show that coelomocytes respond to immune challenge from lipopolysaccharide with significant elevations in profilin transcripts per coelomyocyte.


Dev Comp Immunol


Smith LC,Britten RJ,Davidson EH




Has Abstract


1995-05-01 00:00:00














  • Transcriptional regulation of type I interferon gene expression by interferon regulatory factor-3 in Japanese flounder, Paralichthys olivaceus.

    abstract::Type I interferon (IFN) induces the antiviral response in innate immunity. The type I IFN gene cloned from Japanese flounder (Paralichthys olivaceus) has a length of 1189 bp and consisting of 5 exons and 4 introns. In a phylogenetic tree of type I IFNs, Japanese flounder grouped with other Acanthopterygii. To gain ins...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Ohtani M,Hikima J,Hwang SD,Morita T,Suzuki Y,Kato G,Kondo H,Hirono I,Jung TS,Aoki T

    更新日期:2012-04-01 00:00:00

  • Demonstration of T cell and macrophage progenitors in carp (Cyprinus carpio) kidney hematopoietic tissues. Development of clonal assay system for carp hematopoietic cells.

    abstract::Single hematopoietic cells from carp (Cyprinus carpio) kidney were seeded to each well of 96-well plates and cultured in the presence of a supporting cell layer and conditioned media (CM). The CM were obtained from bulk-cultured carp hematopoietic cells, in which T and macrophage-lineage cells rapidly proliferated as ...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Katakura F,Yamaguchi T,Yoshida M,Moritomo T,Nakanishi T

    更新日期:2010-06-01 00:00:00

  • Role of lectins in the innate immunity of horseshoe crab.

    abstract::We have purified five types of lectins, named tachylectins, from circulating hemocytes and hemolymph plasma of the Japanese horseshoe crab, Tachypleus tridentatus. Tachylectin-1 interacts with Gram-negative bacteria probably through 2-keto-3-deoxyoctonate, one of the constituents of lipopolysaccharides (LPS). Tachylec...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章,评审


    authors: Kawabata S,Iwanaga S

    更新日期:1999-06-01 00:00:00

  • Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium.

    abstract::In recent years zebrafish has emerged as an excellent model for studying the Cxcl8 signaling pathway in inflammation elicited upon tissue damage or infection. Zebrafish has two true homologs of mammalian CXCL8, named Cxcl8-l1 and Cxcl8-l2. Previously, we have shown that in wound-associated inflammation, these chemokin...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: de Oliveira S,Lopez-Muñoz A,Martínez-Navarro FJ,Galindo-Villegas J,Mulero V,Calado Â

    更新日期:2015-03-01 00:00:00

  • Surface immunoglobulin on granular and agranular leukocytes in the thymus and spleen of the snapping turtle, Chelydra serpentina.

    abstract::Spleen and thymus suspensions from the turtle, Chelydra serpentina were examined by indirect immunofluorescence and found to contain both agranulocytes and granulocytes positive for surface Ig. Among the splenic agranulocytes , 50% of the lymphocyte and monocyte population was positive for surface Ig. In the thymus on...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Mead KF,Borysenko M

    更新日期:1984-01-01 00:00:00

  • Molecular identification and expression analysis of TAB1 from orange-spotted grouper (Epinephelus coioides).

    abstract::Transforming growth factor-β activated kinase 1 (TAK1) is a crucial signal transducer in multiple signaling pathways. TAK1 binds TAB1, TAB2, and TAB3, which act as activators and adaptors that specifically regulate the activation of TAK1. To date, the role of TABs is largely unknown in fish. In the present study, a TA...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Hu YZ,Li X,Han R,Jiang B,Li YW,Dan XM,Li AX

    更新日期:2019-01-01 00:00:00

  • DNA content and proliferation of rat thymocytes.

    abstract::Scanning microdensitometric analysis of Feulgen stained thymocytes from rats aged 1 to 71 days revealed the presence of a number of waves of cell proliferation which may correlate with the development of functionally distinct T-cell subpopulations. In addition, considerable numbers of hypodiploid cells were seen. It i...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Rippin JW

    更新日期:1984-01-01 00:00:00

  • Detection of phenoloxidase activity in early stages of the Pacific oyster Crassostrea gigas (Thunberg).

    abstract::The presence of phenoloxidase (PO) activity was detected in different developmental stages of the Pacific oyster, Crassostrea gigas. A significant reduction in PO activity was observed from the 6h embryo stage to the day 11 larvae by spectrophotometry. A progressive increase was also observed from the day 13 larvae ri...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Thomas-Guyon H,Gagnaire B,Bado-Nilles A,Bouilly K,Lapègue S,Renault T

    更新日期:2009-05-01 00:00:00

  • Dynamics of immune cell infiltration in the caecal lamina propria of chickens after neonatal infection with a Salmonella enteritidis strain.

    abstract::Dynamics of leucocyte infiltration and bacterial invasion in the caecal wall were studied after oral infection of 2-day-old chicks with Salmonella enterica ser. Enteritidis. Bacteria invaded the lamina propria of the caecal wall from 12h post-challenge onwards. Bacteriological examination of internal organs (liver, sp...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Van Immerseel F,De Buck J,De Smet I,Mast J,Haesebrouck F,Ducatelle R

    更新日期:2002-05-01 00:00:00

  • Differential immune response of rainbow trout (Oncorhynchus mykiss) at early developmental stages (larvae and fry) against the bacterial pathogen Yersinia ruckeri.

    abstract::Innate immune factors play a crucial role in survival of young fish especially during early stages of life when adaptive immunity is not fully developed. In the present study, we investigated the immune response of rainbow trout (Oncorhynchus mykiss) larvae and fry at an early stage of development. We exposed 17 and 8...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Chettri JK,Raida MK,Kania PW,Buchmann K

    更新日期:2012-02-01 00:00:00

  • Functional characterization of STATa/b genes encoding transcription factors from Branchiostoma belcheri.

    abstract::The signal transducer and activator of transcription (STAT), as an important transcription factor of the Janus kinase (JAK)-STAT signaling pathway, is pivotal for development and immunity and well documented in vertebrates. However, the STAT gene has not been reported in chordate amphioxus (Branchiostoma belcheri). In...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Cao Y,Fang T,Fan M,Wang L,Lv C,Xiaojun Song,Jin P,Ma F

    更新日期:2021-01-01 00:00:00

  • The expression of CD8α discriminates distinct T cell subsets in teleost fish.

    abstract::CD8, belonging to the TCR complex, is the main marker molecule of CTLs. Although CD8 genes have been detected in many fish species, the analysis of teleost CD8+ cells has been limited because of the lack of antibodies. Using newly established mAbs against rainbow trout CD8α, we found high ratios of CD8α+ cells in trou...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Takizawa F,Dijkstra JM,Kotterba P,Korytář T,Kock H,Köllner B,Jaureguiberry B,Nakanishi T,Fischer U

    更新日期:2011-07-01 00:00:00

  • Lymphocyte markers in the bovine foetus.

    abstract::The ontogeny of lymphocyte surface markers was studied in thymus, retropharyngeal lymph nodes, spleen, bone marrow, and liver of 48 bovine foetuses, 80-280 days of gestation. The markers examined were the spontaneous (E) rosette against sheep erythrocytes (SRBCs) in foetal calf serum (E/FCS), in medium supplemented wi...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Higgins DA,Stack MJ,Richardson C

    更新日期:1983-04-01 00:00:00

  • SIKE of black carp is a substrate of TBK1 and suppresses TBK1-mediated antiviral signaling.

    abstract::RIG-I like receptor (RLR) signaling functions importantly in host innate immune response against RNA virus, which is tightly regulated by a number of mechanisms to prevent aberrant interferon production. The suppressor of IKKε (SIKE) has been identified as a suppressor of IKKε and TBK1, which are key components of RLR...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Li J,Yan C,Liu J,Yan J,Feng H

    更新日期:2019-01-01 00:00:00

  • A novel C-type lectin (FcLec4) facilitates the clearance of Vibrio anguillarum in vivo in Chinese white shrimp.

    abstract::C-type lectins play important roles in innate immunity of invertebrates. In the present study, we report a novel C-type lectin, named FcLec4, from the Chinese white shrimp Fenneropenaeus chinensis. FcLec4 contains a single carbohydrate recognition domain (CRD) with a putative signal peptide. Phylogenetic analysis indi...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Wang XW,Zhang XW,Xu WT,Zhao XF,Wang JX

    更新日期:2009-09-01 00:00:00

  • A Kazal-type serine proteinase inhibitor SPIPm2 from the black tiger shrimp Penaeus monodon is involved in antiviral responses.

    abstract::A five-domain Kazal-type serine proteinase inhibitor, SPIPm2, from Penaeus monodon has recently been implicated in antiviral responses for it is up-regulated upon viral infection and needs further studies. The SPIPm2 genomic gene was composed of seven exons and six introns. The genomic DNA segments coding for each Kaz...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Donpudsa S,Ponprateep S,Prapavorarat A,Visetnan S,Tassanakajon A,Rimphanitchayakit V

    更新日期:2010-10-01 00:00:00

  • The immunomodulation of a novel tumor necrosis factor (CgTNF-1) in oyster Crassostrea gigas.

    abstract::Tumor necrosis factor (TNF) is one of the most important cytokines involved in many processes in both vertebrate and invertebrate. In the present study, a new tumor necrosis factor with a typical TNF domain was identified in oyster Crassostrea gigas (designated CgTNF-1). CgTNF-1 shared low sequence identity and simila...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Sun Y,Zhou Z,Wang L,Yang C,Jianga S,Song L

    更新日期:2014-08-01 00:00:00

  • Immunity against selected piscine flagellates.

    abstract::This discussion is on immune response to Amyloodinium ocellatum, Cryptobia salmositica, Trypanoplasma borreli and Trypanosoma carassii. Piscidin and histone-like proteins enhance innate resistance to Amyloodinium. Fish that are naturally resistant to Cryptobia and Trypanoplasma can be bred. Cryptobia resistance in cha...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章,评审


    authors: Woo PT,Ardelli BF

    更新日期:2014-04-01 00:00:00

  • Evolution of classic Hodgkin lymphoma in correlation to changes in the lymphoid organ structure of vertebrates.

    abstract::In order to integrate evolutionary concepts into lymphoma research we mapped features of classic Hodgkin lymphoma (a disease which has been recently described to be derived from germinal center B-cells) onto a phylogenetic tree of vertebrates. Secondly, we matched the phylogenetic occurrence of classic Hodgkin lymphom...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章,评审


    authors: Seitz V,Hummel M,Walter J,Stein H

    更新日期:2003-01-01 00:00:00

  • In situ lymphocyte apoptosis in larval Xenopus laevis, the South African clawed toad.

    abstract::During Anuran metamorphosis larval structures regress, adult structures form anew and impaired T cell immune functions are noted, as are alterations in endogenous glucocorticoid titers. In situ histological data, after staining for DNA fragmentation, reveal patterns of lymphocyte suicide in the thymus and spleen of no...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Grant P,Clothier RH,Johnson RO,Ruben LN

    更新日期:1998-07-01 00:00:00

  • Functions of Bombyx mori cathepsin L-like in innate immune response and anti-microbial autophagy.

    abstract::Cathepsins belongs to the cysteine protease family, which are activated by an acidic environment. They play essential biological roles in the innate immunity and development of animals. Here, we identified a 62 kDa cathepsin L-like protease from the silkworm Bombyx mori. It contained putative conserved domains, includ...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Sun YX,Chen C,Xu WJ,Abbas MN,Mu FF,Ding WJ,Zhang HJ,Li J

    更新日期:2021-03-01 00:00:00

  • Genetic and molecular basis of the immune system in the brachiopod Lingula anatina.

    abstract::The extension of comparative immunology to non-model systems, such as mollusks and annelids, has revealed an unexpected diversity in the complement of immune receptors and effectors among evolutionary lineages. However, several lophotrochozoan phyla remain unexplored mainly due to the lack of genomic resources. The in...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Gerdol M,Luo YJ,Satoh N,Pallavicini A

    更新日期:2018-05-01 00:00:00

  • Molecular characterization, phylogeny and expression of a hepcidin gene in the blotched snakehead Channa maculata.

    abstract::A hepcidin-like gene (cmHep) was cloned and characterized from the liver of the blotched snakehead Channa maculata. The complete cmHep cDNA was 756 bp in length, containing an open reading frame of 270 bp (encoding 89 amino acids), flanked by 210 bp and 276 bp of 5' and 3' untranslated regions, respectively. The deduc...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Gong LC,Wang H,Deng L

    更新日期:2014-05-01 00:00:00

  • Transcriptional dynamics of immune, growth and stress related genes in skeletal muscle of the fine flounder (Paralichthys adpersus) during different nutritional statuses.

    abstract::The effects of stress on immune activity and growth in early vertebrates have not been studied in detail. The present study used fine flounder (Paralichthys adspersus) skeletal muscle as a model to evaluate molecules involved in the stress response, including the glucocorticoid receptors, foxo1/3, and the target genes...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Valenzuela CA,Escobar D,Perez L,Zuloaga R,Estrada JM,Mercado L,Valdés JA,Molina A

    更新日期:2015-11-01 00:00:00

  • The effect of aging on T cell responses in the horse.

    abstract::Horses greater than 20 years of age exhibit alterations in their immune responses similar to those observed in other aged individuals. The purpose of this study was to characterize immunosenescence in a population of aged ponies. The peripheral blood mononuclear cells (PBMC) from aged ponies exhibited a decreased prol...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Horohov DW,Kydd JH,Hannant D

    更新日期:2002-01-01 00:00:00

  • Receptors for complement on echinoid phagocytes. II. Purified human complement mediates echinoid phagocytosis.

    abstract::The ingestion of sheep erythrocytes (E) coated with specific IgM antibody (EA) and various purified human complement components (EAC 1, EAC 14, EAC 142, EAC 1423b, EAC 43b) by echinoid phagocytes was examined. E, EA, EAC 1, EAC 14 and EAC 142 were ingested at a similar and very low level, while a strong opsonic effect...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Bertheussen K

    更新日期:1982-10-01 00:00:00

  • Developmental regulation of chicken surfactant protein A and its localization in lung.

    abstract::Surfactant Protein A (SP-A) is a collagenous C-type lectin (collectin) that plays an important role in the early stage of the host immune response. In chicken, SP-A (cSP-A) is expressed as a 26 kDa glycosylated protein in the lung. Using immunohistochemistry, cSP-A protein was detected mainly in the lung lining fluid ...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Zhang W,Cuperus T,van Dijk A,Skjødt K,Hansen S,Haagsman HP,Veldhuizen EJ

    更新日期:2016-08-01 00:00:00

  • Botryllus schlosseri allorecognition: tackling the enigma.

    abstract::Allorecognition has been well-studied in the context of vertebrate adaptive immunity and recognition of the Major Histocompatibility Complex (MHC), which is the central event of vertebrate immune responses. Although allorecognition systems have been identified throughout the metazoa, recent results have shown that the...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章,评审


    authors: Taketa DA,De Tomaso AW

    更新日期:2015-01-01 00:00:00

  • Proteomic analysis of host responses to Marek's disease virus infection in spleens of genetically resistant and susceptible chickens.

    abstract::Resistance to Marek's disease (MD) in chickens is genetically regulated and there are lines of chickens with differential susceptibility or resistance to this disease. The present study was designed to study comparative changes in the spleen proteomes of MD-susceptible B19 and MD-resistant B21 chickens in response to ...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Thanthrige-Don N,Parvizi P,Sarson AJ,Shack LA,Burgess SC,Sharif S

    更新日期:2010-07-01 00:00:00

  • Identification of the up-regulated expression genes in hemocytes of variously colored abalone (Haliotis diversicolor Reeve, 1846) challenged with bacteria.

    abstract::Variously colored abalone (Haliotis diversicolor Reeve, 1846), which is an important commercial aquatic species and has been widely cultured, frequently suffers from bacterial infection. Knowledge of the defense mechanism in this animal is still lacking and, so far few genes related to immune responses in abalones hav...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章


    authors: Wang KJ,Ren HL,Xu DD,Cai L,Yang M

    更新日期:2008-01-01 00:00:00