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Blimp-1 is involved in B cell activation and maturation in Nile tilapia (Oreochromis niloticus).

Abstract：

:B lymphocyte-induced maturation protein 1 (Blimp-1), a transcription factor containing zinc finger, is required and sufficient to trigger terminal differentiation of B cells in mammals. The Blimp-1 (OnBlimp-1) from Nile tilapia (Oreochromis niloticus) was identified and characterized its expression pattern during B cell activation and maturation. The cDNA of OnBlimp-1 open reading frame is 2547 bp encoding a protein of 848 amino acids and the predicted molecular weight is 93.36 kDa. OnBlimp-1 contains a SET domain and five ZnF_C2H2 domains, which shares high homology with that of other species. OnBlimp-1 transcription was detected in all examined tissues with high expression in the spleen (SPL). Analysis of sorted lymphocyte populations, including IgM+ and IgM- cells from peripheral blood (PBL), SPL and anterior kidney (AK), indicated that the OnBlimp-1 transcription was highly expressed in the IgM+ B cells. Upon LPS stimulation, OnBlimp-1 expression was up-regulated in tissues of PBL, SPL and AK significantly. The expression of OnBlimp-1, as well as the secreted IgM, was significantly up-regulated in the SPL and AK leukocytes stimulated with anti-OnIgM monoclonal antibody and LPS in vitro, respectively. Above results suggest that OnBlimp-1, a cytokine regulating the terminal differentiation of activated B cells to antibody-secreting cells, is likely to play important roles in B cell activation and maturation in Nile tilapia.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Wu L,Zhou E,Gao A,Kong L,Wu S,Bian X,Li Y,Li B,Fu S,Guo Z,Ye J

doi

10.1016/j.dci.2019.05.002

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

137-147

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(19)30026-6

journal_volume

98

pub_type

杂志文章

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