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Characterization and signaling pathway analysis of interferon-kappa in bovine.

Abstract：

:A bovine interferon-kappa (BoIFN-κ) gene was amplified, which encodes a protein of 215 amino acids sharing 63% identity with human IFN-κ. BoIFN-κ was demonstrated to have antiviral and antiproliferative activities. Moreover, BoIFN-κ was shown to be highly sensitive to trypsin, however, it remained stable despite changes in pH and temperature. Result showed that BoIFN-κ can bind with bovine type I IFN receptors, and the antiviral activity can be blocked by antibodies against type I IFN receptors or BoIFN-κ. Additionally, BoIFN-κ can induce the transcription of Mx1, ISG15 and ISG56 gene, as well as the expression of Mx1 protein. The NF-κB, ISRE, and BoIFN-β promoter can all be activated by BoIFN-κ. This study revealed that BoIFN-κ exhibits the typical characteristics of type I IFNs and exerts antiviral activity via activation of the JAK-STAT signaling pathway. Overall, these findings will enrich the current knowledge about IFN-κ and facilitate further research on the role of type I IFN in antiviral defense responses in bovine.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Guo Y,An D,Liu Y,Bao J,Luo X,Cheng X,Wang Y,Gao M,Wang J

doi

10.1016/j.dci.2016.09.018

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

213-220

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(16)30303-2

journal_volume

67

pub_type

杂志文章

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