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Chicken interferons, their receptors and interferon-stimulated genes.

Abstract：

:The prevalence of pathogenic viruses is a serious issue as they pose a constant threat to both the poultry industry and to human health. To prevent these viral infections an understanding of the host-virus response is critical, especially for the development of novel therapeutics. One approach in the control of viral infections would be to boost the immune response through administration of cytokines, such as interferons. However, the innate immune response in chickens is poorly characterised, particularly concerning the interferon pathway. This review will provide an overview of our current understanding of the interferon system of chickens, including their cognate receptors and known interferon-stimulated gene products.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Goossens KE,Ward AC,Lowenthal JW,Bean AG

doi

10.1016/j.dci.2013.05.020

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

370-6

issue

3

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(13)00161-4

journal_volume

41

pub_type

杂志文章,评审

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