当前位置： SCI文献检索 > DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY期刊下所有文献 > Transduction of binding affinity by B lymphocytes: a new dimension in immunological regulation.

Transduction of binding affinity by B lymphocytes: a new dimension in immunological regulation.

Abstract：

:To date, immunologists have operated with two primary paradigms governing the antibody response: (1) that affinity maturation is primarily dependent upon antigen-driven selection of both the germline and somatically amended repertoires, and (2) that antibody effector function is isotypically determined. The teleost model now suggests that these classical paradigms should be broadened to incorporate the ability of the B cell to transduce the strength of antigen recognition (affinity) into structural modifications of its antibody product, which, in turn, modulates the antibody's effector function. Although this relationship, thus far, has only been examined and demonstrated in the teleost, we find a number of the individual elements of this structural/functional relationship have been reported for mammalian IgM, which prompts future investigations into its universality. In sum, these findings suggest a heretofore unrecognized feature of B lymphocyte affinity discrimination, which transduces the affinity of antigen recognition into functionally modified antibodies.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Ye J,Bromage E,Kaattari I,Kaattari S

doi

10.1016/j.dci.2011.01.015

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

982-90

issue

9

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(11)00016-4

journal_volume

35

pub_type

杂志文章,评审

相关文献

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY文献大全
  • Expression of an inducible nitric oxide synthase gene in rainbow trout Oncorhynchus mykiss.

    abstract：:Using oligonucleotide primers based on mammalian nitric oxide synthases (NOS), expression of an inducible NOS (iNOS) gene was detected in head kidney and gill tissue of bacterially-challenged rainbow trout. Three overlapping fragments were amplified by RT-PCR and used to construct a contiguous sequence of 1410bp, with...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(98)00036-6

    authors： Laing KJ,Hardie LJ,Aartsen W,Grabowski PS,Secombes CJ

    更新日期：1999-01-01 00:00:00

  • Hydrocortisone suppresses the chemiluminescent response of striped bass phagocytes.

    abstract：:Phagocytic cells obtained from the pronephros of striped bass (Morone saxatilis) were exposed in vitro to various levels of hydrocortisone acetate. This treatment reduced the normal ability of the cells to generate a chemiluminescent response when exposed to bacteria or phorbol myristate acetate. Although the levels o...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(85)90061-8

    authors： Stave JW,Roberson BS

    更新日期：1985-01-01 00:00:00

  • Tissue-specific expression and molecular modeling of cytosolic manganese superoxide dismutases from the white shrimp Litopenaeus vannamei.

    abstract：:Manganese superoxide dismutases (MnSODs) are usually mitochondrial enzymes, although there are few examples of cytosolic MnSODs (cMnSOD). We have previously characterized a cMnSOD cDNA from Litopenaeus vannamei hemocytes, and to obtain new insights into the tissue specific expression and the protein structure, we char...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2006.11.007

    authors： Gómez-Anduro GA,Sotelo-Mundo RR,Muhlia-Almazán A,Yepiz-Plascencia G

    更新日期：2007-01-01 00:00:00

  • In vitro production of hydrogen peroxide by the amoebocytes of the scallop, Patinopecten yessoensis (Jay).

    abstract：:In vitro production of hydrogen peroxide (H2O2) by the amoebocytes of the scallop, Patinopecten yessoensis, was studied. The authors first confirmed the availability of the direct quantitative method using homovanillic acid, and found that both resting and stimulated amoebocytes produced H2O2. However, the latter show...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(85)90004-7

    authors： Nakamura M,Mori K,Inooka S,Nomura T

    更新日期：1985-07-01 00:00:00

  • The first report of siglec-3/CD33 gene in a teleost (rock bream, Oplegnathus fasciatus): An analysis of its spatial expression during stimulation to red seabream iridovirus (RSIV) and two bacterial pathogens.

    abstract：:Siglec-3/CD33 is a myeloid-specific inhibitory receptor that is expressed on cells of the immune system, where it is believed to play a regulatory role, modulating the inflammatory and immune responses. We characterized CD33 (RbCD33) in rock bream which is a transmembrane protein with two IG-like domains and a cytopla...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2018.02.005

    authors： Jeswin J,Joo MS,Jeong JM,Bae JS,Choi KM,Cho DH,Park SI,Park CI

    更新日期：2018-07-01 00:00:00

  • Functional conservation of suppressors of cytokine signaling proteins between teleosts and mammals: Atlantic salmon SOCS1 binds to JAK/STAT family members and suppresses type I and II IFN signaling.

    abstract：:Suppressor of cytokine signaling (SOCS) proteins are crucially involved in the control of inflammatory responses through their impact on various signaling pathways including the JAK/STAT pathway. Although all SOCS protein family members are identified in teleost fish, their functional properties in non-mammalian verte...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2014.02.009

    authors： Skjesol A,Liebe T,Iliev DB,Thomassen EI,Tollersrud LG,Sobhkhez M,Lindenskov Joensen L,Secombes CJ,Jørgensen JB

    更新日期：2014-07-01 00:00:00

  • RNA-seq identifies integrin alpha of kuruma shrimp Marsupenaeus japonicus as a candidate molecular marker for phagocytic hemocytes.

    abstract：:Phagocytosis is main cellular immunity, however, it is still unknown or debated upon which types of hemocyte contributes phagocytosis in penaeid shrimps. The hemocyte characterization in kuruma shrimp have been mainly performed based on its morphology by microscopic observation. Therefore, establishment of molecular m...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2017.12.014

    authors： Koiwai K,Kondo H,Hirono I

    更新日期：2018-04-01 00:00:00

  • JAK and STAT members in channel catfish: Identification, phylogenetic analysis and expression profiling after Edwardsiella ictaluri infection.

    abstract：:The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway is one of the main pleiotropic cascades used to transmit information from extracellular receptors to the nucleus, which results in DNA transcription and expression of genes involved in immunity, proliferation, differentiat...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2017.12.019

    authors： Jin Y,Zhou T,Li N,Liu S,Xu X,Pan Y,Tan S,Shi H,Yang Y,Yuan Z,Wang W,Luo J,Gao D,Dunham R,Liu Z

    更新日期：2018-04-01 00:00:00

  • Molecular characterisation of RIG-I-like helicases in the black flying fox, Pteropus alecto.

    abstract：:The RIG-I like helicases, RIG-I, mda5 and LGP2 are an evolutionarily conserved family of cytosolic pattern recognition receptors important in the recognition of viral RNA, and responsible for the innate induction of interferons and proinflammatory cytokines upon viral infection. Bats are natural reservoir hosts to a v...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2011.11.008

    authors： Cowled C,Baker ML,Zhou P,Tachedjian M,Wang LF

    更新日期：2012-04-01 00:00:00

  • Regional and global changes in TCRalphabeta T cell repertoires in the gut are dependent upon the complexity of the enteric microflora.

    abstract：:The repertoire of gut associated T cells is shaped by exposure to microbes, including the natural enteric microflora. Previous studies compared the repertoire of gut associated T cell populations in germ free (GF) and conventional mammals often focussing on intra-epithelial lymphocyte compartments. Using GF, conventio...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2009.11.009

    authors： Mwangi WN,Beal RK,Powers C,Wu X,Humphrey T,Watson M,Bailey M,Friedman A,Smith AL

    更新日期：2010-04-01 00:00:00

  • An ancient and variable mannose-binding lectin from the coral Acropora millepora binds both pathogens and symbionts.

    abstract：:Corals form the framework of the world's coral reefs and are under threat from increases in disease and bleaching (symbiotic dysfunction), yet the mechanisms of pathogen and symbiont recognition remain largely unknown. Here we describe the isolation and characterisation of an ancient mannose-binding lectin in the cora...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2008.05.010

    authors： Kvennefors EC,Leggat W,Hoegh-Guldberg O,Degnan BM,Barnes AC

    更新日期：2008-01-01 00:00:00

  • Sea urchin immune cells as sentinels of environmental stress.

    abstract：:Echinoderms, an ancient and very successful phylum of marine invertebrates, play a central role in the maintenance of ecosystem integrity and are constantly exposed to environmental pressure, including: predation, changes in temperature and pH, hypoxia, pathogens, UV radiation, metals, toxicants, and emerging pollutan...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2014.11.013

    authors： Pinsino A,Matranga V

    更新日期：2015-03-01 00:00:00

  • Trypanosoma carassii hsp70 increases expression of inflammatory cytokines and chemokines in macrophages of the goldfish (Carassius auratus L.).

    abstract：:We report on the cloning and characterization of Trypanosoma carassii 70 KDa heat shock protein (hsp70). T. carassii hsp70 was secreted/excreted into culture medium in vitro and was recognized by sera from infected fish. Recombinant hsp70 (rhsp70) activated goldfish macrophages and stimulated the production of pro-inf...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2009.06.003

    authors： Oladiran A,Belosevic M

    更新日期：2009-10-01 00:00:00

  • In vitro organ culture of embryonic bursa of Fabricius.

    abstract：:An in vitro method for organ culture of embryonic bursa of Fabricius is presented. It is shown that bursa cells proliferate in in vitro culture as evidenced by [3H]-thymidine incorporation. We assessed the expression of B-cell alloantigen (Bu-la and Bu-lb), class I (B-F) and class II (B-L) antigens of chicken major hi...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(90)90095-v

    authors： Nowak JS,Vainio O,Lassila O

    更新日期：1990-04-01 00:00:00

  • Serum amyloid A transcription in Atlantic salmon (Salmo salar L.) hepatocytes is enhanced by stimulation with macrophage factors, recombinant human IL-1 beta, IL-6 and TNF alpha or bacterial lipopolysaccharide.

    abstract：:Serum amyloid A (A-SAA) has previously been reported to be an acute-phase protein in salmonids. Hepatocytes represent a major source of A-SAA in salmonids, but nothing is known about hepatocyte SAA synthesis in fish. In the present work, the expression of A-SAA transcripts in primary cultures of Atlantic salmon hepato...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(00)00022-7

    authors： Jørgensen JB,Lunde H,Jensen L,Whitehead AS,Robertsen B

    更新日期：2000-09-01 00:00:00

  • Transfection of crayfish hematopoietic tissue cells.

    abstract：:Transfection is a powerful tool useful for studying gene function. Establishing transfection methods that enable highly efficient DNA uptake has become increasingly important. The crayfish hematopoietic tissue (Hpt) cell cultures have been proven to be suitable for studies on immunity and cell differentiation in crust...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2018.07.005

    authors： Shi H,Ruan L,Söderhäll I,Söderhäll K,Xu X

    更新日期：2018-11-01 00:00:00

  • Purification and binding properties of porcine plasma ficolin that binds Actinobacillus pleuropneumoniae.

    abstract：:Previous studies demonstrated that porcine plasma ficolin binds the important pig pathogen Actinobacillus pleuropneumoniae (APP) in an N-acetylglucosamine-dependent manner. In the present study, attempts to characterize the bacterial-binding properties of ficolin indicated ficolin is the major porcine plasma protein t...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(03)00057-0

    authors： Brooks AS,DeLay JP,Hayes MA

    更新日期：2003-10-01 00:00:00

  • Mucosal immunity in the gut: the non-vertebrate perspective.

    abstract：:Much is now known about the vertebrate mechanisms involved in mucosal immunity, and the requirement of commensal microbiota at mucosal surfaces for the proper functioning of the immune system. In comparison, very little is known about the mechanisms of immunity at the barrier epithelia of non-vertebrate organisms. The...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2013.03.009

    authors： Garcia-Garcia E,Galindo-Villegas J,Mulero V

    更新日期：2013-07-01 00:00:00

  • Ultrastructural analysis of leucocyte interaction with tumour targets in a teleost, Cyprinus carpio L.

    abstract：:The first step in natural killer activity, target cell binding, was investigated ultrastructurally in order to identify presumptive cytotoxic cells. After incubation of unfractioned peripheral blood cells of the carp, Cyprinus carpio L., with HeLa tumour cells as targets, regular conjugate forming was observed. Target...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(88)90055-9

    authors： Bielek E

    更新日期：1988-10-01 00:00:00

  • Genetic and molecular basis of the immune system in the brachiopod Lingula anatina.

    abstract：:The extension of comparative immunology to non-model systems, such as mollusks and annelids, has revealed an unexpected diversity in the complement of immune receptors and effectors among evolutionary lineages. However, several lophotrochozoan phyla remain unexplored mainly due to the lack of genomic resources. The in...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2017.12.021

    authors： Gerdol M,Luo YJ,Satoh N,Pallavicini A

    更新日期：2018-05-01 00:00:00

  • Metabolic responses of clam Ruditapes philippinarum exposed to its pathogen Vibrio tapetis in relation to diet.

    abstract：:We investigated the effect of brown ring disease (BRD) development and algal diet on energy reserves and activity of enzymes related to energy metabolism, antioxidant system and immunity in Manila clam, Ruditapes philippinarum. We found that algal diet did not impact the metabolic response of clams exposed to Vibrio t...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2016.02.026

    authors： Richard G,Guérard F,Corporeau C,Lambert C,Paillard C,Pernet F

    更新日期：2016-07-01 00:00:00

  • Natural hemolytic activity of snake serum. II. Heterogeneity of putative natural antibody and levels of hemolytic activity.

    abstract：:The erythrocytes of various vertebrates, such as mice, rabbits, sheep, chickens, bullfrogs, and toads are lysed by normal snake sera. However, snake erythrocytes were not lysed by serum from different snake species. Putative natural antibody seems with different specificities to comprise heterogeneous antibodies. Thus...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(78)80007-x

    authors： Kawaguchi S,Muramatsu S,Mitsuhashi S

    更新日期：1978-07-01 00:00:00

  • Infection with the trypanosome Crithidia bombi and expression of immune-related genes in the bumblebee Bombus terrestris.

    abstract：:Social bees and other insects are frequently parasitized by a large range of different microorganisms. Among these is Crithidia bombi (Kinetoplastida: Trypanosomatidae), a common gut parasite of bumblebees, Bombus spp. (Insecta: Apidae). Bumblebees are important pollinators in commercial and natural environments. Ther...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2010.02.002

    authors： Schlüns H,Sadd BM,Schmid-Hempel P,Crozier RH

    更新日期：2010-07-01 00:00:00

  • Identification of a novel relish homolog in Chinese shrimp Fenneropenaeus chinensis and its function in regulating the transcription of antimicrobial peptides.

    abstract：:Penaeid shrimp, as an invertebrate, relies on the innate immunity to oppose the microbial invaders. Antimicrobial peptides (AMP) are an integral component of the innate immune system in most organisms and function as an early first line of defense against pathogens, but the knowledge about the pathways to regulate the...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2009.06.001

    authors： Li F,Yan H,Wang D,Priya TA,Li S,Wang B,Zhang J,Xiang J

    更新日期：2009-10-01 00:00:00

  • The relationship between major histocompatibility receptors and innate immunity in teleost fish.

    abstract：:Studies of the innate immune system have recently shown that, in addition to its role in producing the primary response that slows down pathogens, it may also play an important role in initiating and directing the type of response that the adaptive immune system makes. These discoveries have shown a complex web of con...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0145-305x(01)00030-1

    authors： Dixon B,Stet RJ

    更新日期：2001-10-01 00:00:00

  • Invertebrate immune diversity.

    abstract：:The arms race between hosts and pathogens (and other non-self) drives the molecular diversification of immune response genes in the host. Over long periods of evolutionary time, many different defense strategies have been employed by a wide variety of invertebrates. We review here penaeidins and crustins in crustacean...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2010.12.009

    authors： Ghosh J,Lun CM,Majeske AJ,Sacchi S,Schrankel CS,Smith LC

    更新日期：2011-09-01 00:00:00

  • Carbohydrate binding specificity and purification by biospecific affinity chromatography of Ascidia malaca Traust. hemagglutinins.

    abstract：:The carbohydrate specificities of Ascidia malaca serum hemagglutinins were determined by hemagglutination inhibition tests. Analysis of agglutinins against rabbit and human A, B, O erythrocytes suggests that the size of the combining site corresponds to a disaccharide with a specificity for saccharides containing a D...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(82)90007-6

    authors： Parrinello N,Canicattì C

    更新日期：1982-01-01 00:00:00

  • Chicken dendritic cells are susceptible to highly pathogenic avian influenza viruses which induce strong cytokine responses.

    abstract：:Infection with highly pathogenic avian influenza (HPAI) in birds and mammals is associated with severe pathology and increased mortality. We hypothesize that in contrast to low pathogenicity avian influenza (LPAI) infection, HPAI infection of chicken dendritic cells (DC) induces a cytokine deregulation which may contr...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2012.10.011

    authors： Vervelde L,Reemers SS,van Haarlem DA,Post J,Claassen E,Rebel JM,Jansen CA

    更新日期：2013-03-01 00:00:00

  • High sequence variability among hemocyte-specific Kazal-type proteinase inhibitors in decapod crustaceans.

    abstract：:Crustacean hemocytes were found to produce a large number of transcripts coding for Kazal-type proteinase inhibitors (KPIs). A detailed study performed with the crayfish Pacifastacus leniusculus and the shrimp Penaeus monodon revealed the presence of at least 26 and 20 different Kazal domains from the hemocyte KPIs, r...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2009.08.005

    authors： Cerenius L,Liu H,Zhang Y,Rimphanitchayakit V,Tassanakajon A,Gunnar Andersson M,Söderhäll K,Söderhäll I

    更新日期：2010-01-01 00:00:00

  • Characterization and role of suppressor of cytokine signaling 1a (SOCS1a) in a teleost fish, Miichthys miiuy.

    abstract：:The suppressor of cytokine signaling 1 (SOCS1) is a crucial regulator in the immune systems of mammals, which functions classically as a negatively regulator in the IFN signaling pathways. However, data on functional characterization of SOCS1 in lower vertebrates is limited. In this study, we identified and characteri...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2017.09.020

    authors： Zhao X,Huo R,Song W,Xu T

    更新日期：2018-01-01 00:00:00