Hydrocortisone suppresses the chemiluminescent response of striped bass phagocytes.

Abstract:

:Phagocytic cells obtained from the pronephros of striped bass (Morone saxatilis) were exposed in vitro to various levels of hydrocortisone acetate. This treatment reduced the normal ability of the cells to generate a chemiluminescent response when exposed to bacteria or phorbol myristate acetate. Although the levels of hydrocortisone were higher than is physiological for fish, suppression was dose dependent and was not attributable to a reduction in cell viability. Whereas phagocytic chemiluminescence has been linked to the respiratory burst and bactericidal activity, the possibility exists that stress-induced elevations in serum corticosteroids lead to increased susceptibility to infection.

journal_name

Dev Comp Immunol

authors

Stave JW,Roberson BS

doi

10.1016/0145-305x(85)90061-8

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

77-84

issue

1

eissn

0145-305X

issn

1879-0089

pii

0145-305X(85)90061-8

journal_volume

9

pub_type

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