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The inhibitory effect of environmental ammonia on Danio rerio LPS induced acute phase response.

Abstract：

:Ammonia is a toxic by-product of amino acid catabolism and a common environmental pollutant that has been associated with increased disease susceptibility in fish although the mechanism is not well understood. We addressed the hypothesis that elevated environmental ammonia acts by impairing the acute phase response (APR). Specifically, we determined the impact of sub-lethal acute (24 h) and chronic (14 d) ammonia exposure on acute phase protein gene expression in zebrafish (Danio rerio) in response to a challenge with bacterial lipopolysaccharide (LPS: i.p. 10 μg/g after 24h). A panel of LPS-responsive genes (SAA, HAMP, LECT2, Hp and IL1β) were identified and evaluated by real-time quantitative PCR. Ammonia was found to impair induction of SAA, HAMP and LECT2 by 50-90%. Both short (15 min, 1h and 24h) and long-term (14 days) exposure to high environmental ammonia concentrations significantly elevated whole-body cortisol levels compared with control fish. Our results reveal for the first time that exposure to high environmental levels of ammonia suppresses the innate immune response in fish. We hypothesize that high environmental ammonia-mediated elevation of cortisol levels in zebrafish may be playing a key role in this immunosuppression, while the mechanisms involved remains to be elucidated.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Gonçalves AF,Páscoa I,Neves JV,Coimbra J,Vijayan MM,Rodrigues P,Wilson JM

doi

10.1016/j.dci.2011.04.008

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

279-88

issue

2

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(11)00123-6

journal_volume

36

pub_type

杂志文章

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