Abstract:
:RNA interference (RNAi) controls gene expression in eukaryotic cells and thus, cellular homeostasis. In addition, in plants, nematodes and arthropods it is a central antiviral effector mechanism. Antiviral RNAi has been well described as a cell autonomous response, which is triggered by double-stranded RNA (dsRNA) molecules. This dsRNA is the precursor for the silencing of viral RNA in a sequence-specific manner. In plants, systemic antiviral immunity has been demonstrated, however much less is known in animals. Recently, some evidence for a systemic antiviral response in arthropods has come to light. Cell autonomous RNAi may not be sufficient to reach an efficient antiviral response, and the organism might rely on the spread and uptake of an RNAi signal of unknown origin. In this review, we offer a perspective on how RNAi-mediated antiviral immunity could confer systemic protection in insects and we propose directions for future research to understand the mechanism of RNAi-immune signal sorting, spreading and amplification.
journal_name
Dev Comp Immunoljournal_title
Developmental and comparative immunologyauthors
Karlikow M,Goic B,Saleh MCdoi
10.1016/j.dci.2013.05.004subject
Has Abstractpub_date
2014-01-01 00:00:00pages
85-92issue
1eissn
0145-305Xissn
1879-0089pii
S0145-305X(13)00131-6journal_volume
42pub_type
杂志文章,评审abstract::Beta_defensin have been solely found in vertebrates until β-defensin-like peptides were described as transcript isoforms in two species of Panulirus genus. They were considered as putative antimicrobials since their biological activity have not been demonstrated. Here we purified and characterized a defensin-like pept...
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journal_title:Developmental and comparative immunology
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journal_title:Developmental and comparative immunology
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journal_title:Developmental and comparative immunology
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journal_title:Developmental and comparative immunology
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journal_title:Developmental and comparative immunology
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doi:10.1016/j.dci.2008.06.006
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journal_title:Developmental and comparative immunology
pub_type: 杂志文章
doi:10.1016/0145-305x(85)90113-2
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journal_title:Developmental and comparative immunology
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journal_title:Developmental and comparative immunology
pub_type: 杂志文章
doi:10.1016/j.dci.2008.03.012
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journal_title:Developmental and comparative immunology
pub_type: 杂志文章
doi:10.1016/j.dci.2011.10.015
更新日期:2012-04-01 00:00:00
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journal_title:Developmental and comparative immunology
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doi:10.1016/j.dci.2009.08.004
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journal_title:Developmental and comparative immunology
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journal_title:Developmental and comparative immunology
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journal_title:Developmental and comparative immunology
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journal_title:Developmental and comparative immunology
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journal_title:Developmental and comparative immunology
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journal_title:Developmental and comparative immunology
pub_type: 杂志文章
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journal_title:Developmental and comparative immunology
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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journal_title:Developmental and comparative immunology
pub_type: 杂志文章
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