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Phylogeny, genomic organization and expression of lambda and kappa immunoglobulin light chain genes in a reptile, Anolis carolinensis.

Abstract：

:The reptiles are the last major taxon of jawed vertebrates in which immunoglobulin light chain isotypes have not been well characterized. Using the recently released genome sequencing data, we show in this study that the reptile Anolis carolinensis expresses both lambda and kappa light chain genes. The genomic organization of both gene loci is structurally similar to their respective counterparts in mammals. The identified lambda locus contains three constant region genes each preceded by a joining gene segment, and a total of 37 variable gene segments. In contrast, the kappa locus contains only a single constant region gene, and two joining gene segments with a single family of 14 variable gene segments located upstream. Analysis of junctions of the recombined VJ transcripts reveals a paucity of N and P nucleotides in both expressed lambda and kappa sequences. These results help us to understand the generation of the immunoglobulin repertoire in reptiles and immunoglobulin evolution in vertebrates.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Wu Q,Wei Z,Yang Z,Wang T,Ren L,Hu X,Meng Q,Guo Y,Zhu Q,Robert J,Hammarström L,Li N,Zhao Y

doi

10.1016/j.dci.2009.12.019

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

579-89

issue

5

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(10)00003-0

journal_volume

34

pub_type

杂志文章

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