当前位置： SCI文献检索 > DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY期刊下所有文献 > Functional characterization of STATa/b genes encoding transcription factors from Branchiostoma belcheri.

Functional characterization of STATa/b genes encoding transcription factors from Branchiostoma belcheri.

Abstract：

:The signal transducer and activator of transcription (STAT), as an important transcription factor of the Janus kinase (JAK)-STAT signaling pathway, is pivotal for development and immunity and well documented in vertebrates. However, the STAT gene has not been reported in chordate amphioxus (Branchiostoma belcheri). In this study, we firstly identify and characterize two STAT genes from Branchiostoma belcheri (designed as AmphiSTATa and AmphiSTATb). Secondly, our results reveal that AmphiSTATa is clustered with vertebrate STAT1, STAT2, STAT3 and STAT4, whereas AmphiSTATb is grouped with STAT5 and STAT6 based on phylogenetic analysis. Thirdly, AmphiSTATa and AmphiSTATb are found to widely express in five representative tissues of amphioxus (gill, hepatic cecum, intestine, muscle and notochord) by RT-qPCR analysis. Importantly, both AmphiSTATa and AmphiSTATb can be involved in innate immune responses to LPS stimulation. Fourthly, we demonstrate that AmphiSTATa and AmphiSTATb can form homodimers or heterodimers by Co-IP and Native-PAGE assay, and that AmphiSTATa and AmphiSTATb proteins can also distribute in cytoplasm and nucleus by the subcellular localization. Taken together, our findings not only reveal the roles of AmphiSTATa and AmphiSTATb in amphioxus innate immune responses to LPS stimulation, but provide a new insight into further elucidating the evolution and function of STATs in animals.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Cao Y,Fang T,Fan M,Wang L,Lv C,Xiaojun Song,Jin P,Ma F

doi

10.1016/j.dci.2020.103838

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

103838

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(20)30393-1

journal_volume

114

pub_type

杂志文章

相关文献

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY文献大全
  • Temperature-mediated processes in teleost immunity: differential effects of in vitro and in vivo temperatures on mitogenic responses of channel catfish lymphocytes.

    abstract：:The in vitro mitogenic responses of channel catfish peripheral blood leucocytes to ConA and LPS were differentially affected by both in vitro and in vivo temperatures. The magnitude of the response to LPS was relatively independent of both in vitro culture temperature and in vivo acclimation temperature. The magnitude...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(84)90038-7

    authors： Clem LW,Faulmann E,Miller NW,Ellsaesser C,Lobb CJ,Cuchens MA

    更新日期：1984-04-01 00:00:00

  • The relationship between major histocompatibility receptors and innate immunity in teleost fish.

    abstract：:Studies of the innate immune system have recently shown that, in addition to its role in producing the primary response that slows down pathogens, it may also play an important role in initiating and directing the type of response that the adaptive immune system makes. These discoveries have shown a complex web of con...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0145-305x(01)00030-1

    authors： Dixon B,Stet RJ

    更新日期：2001-10-01 00:00:00

  • Molecular identification and expression analysis of TAB1 from orange-spotted grouper (Epinephelus coioides).

    abstract：:Transforming growth factor-β activated kinase 1 (TAK1) is a crucial signal transducer in multiple signaling pathways. TAK1 binds TAB1, TAB2, and TAB3, which act as activators and adaptors that specifically regulate the activation of TAK1. To date, the role of TABs is largely unknown in fish. In the present study, a TA...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2018.09.014

    authors： Hu YZ,Li X,Han R,Jiang B,Li YW,Dan XM,Li AX

    更新日期：2019-01-01 00:00:00

  • Transfection of crayfish hematopoietic tissue cells.

    abstract：:Transfection is a powerful tool useful for studying gene function. Establishing transfection methods that enable highly efficient DNA uptake has become increasingly important. The crayfish hematopoietic tissue (Hpt) cell cultures have been proven to be suitable for studies on immunity and cell differentiation in crust...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2018.07.005

    authors： Shi H,Ruan L,Söderhäll I,Söderhäll K,Xu X

    更新日期：2018-11-01 00:00:00

  • Trypanosoma carassii hsp70 increases expression of inflammatory cytokines and chemokines in macrophages of the goldfish (Carassius auratus L.).

    abstract：:We report on the cloning and characterization of Trypanosoma carassii 70 KDa heat shock protein (hsp70). T. carassii hsp70 was secreted/excreted into culture medium in vitro and was recognized by sera from infected fish. Recombinant hsp70 (rhsp70) activated goldfish macrophages and stimulated the production of pro-inf...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2009.06.003

    authors： Oladiran A,Belosevic M

    更新日期：2009-10-01 00:00:00

  • A novel IgA-like immunoglobulin in the reptile Eublepharis macularius.

    abstract：:The appearance of antibody genes over evolution coincided with the origin of the vertebrates. Reptiles are of great interest in evolution since they are the link between the amphibians, birds, and mammals. This work describes the presence of a gene in the reptile leopard gecko (Eublepharis macularius) where phylogenet...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2006.09.005

    authors： Deza FG,Espinel CS,Beneitez JV

    更新日期：2007-01-01 00:00:00

  • Functional amyloidogenesis in immunocytes from the colonial ascidian Botryllus schlosseri: Evolutionary perspective.

    abstract：:Cytotoxic morula cells (MCs) and phagocytes are the circulating immunocytes of the colonial ascidian Botryllus schlosseri: Both these cells can synthesise amyloid fibrils, supporting the idea that physiological amyloidogenesis is involved in inflammation and modulation of immune responses. Intriguingly, amyloid of B. ...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2018.09.010

    authors： Franchi N,Ballarin L,Peronato A,Cima F,Grimaldi A,Girardello R,de Eguileor M

    更新日期：2019-01-01 00:00:00

  • Lipopolysaccharide- and β-1,3-glucan-binding protein from Fenneropenaeus merguiensis functions as a pattern recognition receptor with a broad specificity for diverse pathogens in the defense against microorganisms.

    abstract：:In crustaceans, lipopolysaccharide- and β-1,3-glucan-binding protein (LGBP) plays an important role in innate immunity by mediating the recognition of pathogens to host cells. Hereby, LGBP was cloned from Fenneropenaeus merguiensis hepatopancreas. Its full-length cDNA (1280 bp) had an open reading frame of 1101 bp, en...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2016.07.006

    authors： Chaosomboon A,Phupet B,Rattanaporn O,Runsaeng P,Utarabhand P

    更新日期：2017-02-01 00:00:00

  • Tissue-specific expression and molecular modeling of cytosolic manganese superoxide dismutases from the white shrimp Litopenaeus vannamei.

    abstract：:Manganese superoxide dismutases (MnSODs) are usually mitochondrial enzymes, although there are few examples of cytosolic MnSODs (cMnSOD). We have previously characterized a cMnSOD cDNA from Litopenaeus vannamei hemocytes, and to obtain new insights into the tissue specific expression and the protein structure, we char...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2006.11.007

    authors： Gómez-Anduro GA,Sotelo-Mundo RR,Muhlia-Almazán A,Yepiz-Plascencia G

    更新日期：2007-01-01 00:00:00

  • Surface immunoglobulin on granular and agranular leukocytes in the thymus and spleen of the snapping turtle, Chelydra serpentina.

    abstract：:Spleen and thymus suspensions from the turtle, Chelydra serpentina were examined by indirect immunofluorescence and found to contain both agranulocytes and granulocytes positive for surface Ig. Among the splenic agranulocytes , 50% of the lymphocyte and monocyte population was positive for surface Ig. In the thymus on...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(84)90015-6

    authors： Mead KF,Borysenko M

    更新日期：1984-01-01 00:00:00

  • Trypanosoma carassii calreticulin binds host complement component C1q and inhibits classical complement pathway-mediated lysis.

    abstract：:Trypanosoma carassii is an extracellular parasite of economically important fish species that has evolved several strategies to circumvent host immune responses. Proteomic analysis of the excreted/secreted (ES) and surface molecules of the parasite has revealed a number of proteins that may be involved in host-parasit...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2009.11.005

    authors： Oladiran A,Belosevic M

    更新日期：2010-04-01 00:00:00

  • Using models of nucleotide evolution to build phylogenetic trees.

    abstract：:Molecular phylogenetics and its applications are popular and useful tools for making comparative investigations in genetics; however, estimating phylogenetic trees is not always straightforward. Some phylogenetic estimators use an explicit model of nucleotide evolution to estimate evolutionary parameters such as branc...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2004.07.007

    authors： Bos DH,Posada D

    更新日期：2005-01-01 00:00:00

  • The degree of postpartum metabolic challenge in dairy cows is associated with peripheral blood mononuclear cell transcriptome changes of the innate immune system.

    abstract：:Dairy cows undergo a nutrient deficit immediately postpartum when lactational demands exceed nutrient intake. This occurs concurrently to an increased challenge due to bacterial and viral infections, yet ability for pathogen clearance is reduced despite a heightened and often host-damaging inflammatory response. We hy...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2018.11.021

    authors： Mann S,Sipka AS,Grenier JK

    更新日期：2019-04-01 00:00:00

  • Analysis of the attraction of haemocytes from Mytilus edulis by molecules of bacterial origin.

    abstract：:Boyden chamber assays were performed to test the stimulatory effect of different bacterial products on the migratory activity of Mytilus haemocytes. The results indicate that these blood cells exhibit chemotactic as well as chemokinetic reactions. Lipopolysaccharides (LPS) from both Serratia marcescens and Escherichia...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(93)90029-p

    authors： Schneeweiss H,Renwrantz L

    更新日期：1993-09-01 00:00:00

  • Antimicrobial peptide defenses against chytridiomycosis, an emerging infectious disease of amphibian populations.

    abstract：:Chytridiomycosis, an emerging infectious disease (EID) of the skin caused by the chytrid fungus, Batrachochytrium dendrobatidis, has been linked with continuing amphibian population declines in the western USA, Central America, Europe, Africa, and Australia. Genetic analysis suggests that B. dendrobatidis is a recentl...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2004.11.004

    authors： Rollins-Smith LA,Conlon JM

    更新日期：2005-01-01 00:00:00

  • Two different subpopulations of Ig-bearing cells in lymphoid organs of rainbow trout.

    abstract：:In a previous report we described the existence of two structural and antigenic variants of light chains in serum trout Igs, defined by mAbs 2H9 and 2A1. In this report, we analyse the cell distribution, the "in vitro" kinetics of production, and the ontogenic appearance of these two variants. Both variants were alrea...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(94)00058-n

    authors： Sánchez C,Alvarez A,Castillo A,Zapata A,Villena A,Domínguez J

    更新日期：1995-01-01 00:00:00

  • The M2 macrophages induce autophagic vascular disorder and promote mouse sensitivity to urethane-related lung carcinogenesis.

    abstract：:Tumor vessels are known to be abnormal, with typically aberrant, leaky and disordered vessels. Here, we investigated whether polarized macrophage phenotypes are involved in tumor abnormal angiogenesis and what is its mechanism. We found that there was no difference in chemotaxis of polarized M1 and M2 macrophages to l...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2016.01.010

    authors： Li GG,Guo ZZ,Ma XF,Cao N,Geng SN,Zheng YQ,Meng MJ,Lin HH,Han G,Du GJ

    更新日期：2016-06-01 00:00:00

  • MHC class I BFIV gene polymorphisms in four Chinese native chicken breeds.

    abstract：:The major histocompatibility complex (MHC) includes the most polymorphic genes in vertebrates, and balancing selection has been proposed as a main evolutionary force. Here we present one of the first data sets examining the genetic characteristics of chicken MHC I BFIV molecules in four Chinese native breeds, sourced ...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2016.05.004

    authors： Dai Y,Liu XL,Tang QF,Hu XM,Shen XH,Zhang DJ

    更新日期：2016-09-01 00:00:00

  • CsTNF1, a teleost tumor necrosis factor that promotes antibacterial and antiviral immune defense in a manner that depends on the conserved receptor binding site.

    abstract：:Tumor necrosis factor (TNF) is one of the most important cytokines involved in inflammation, apoptosis, cell proliferation, and stimulation of the immune system. The TNF gene has been cloned in teleost fish; however, the in vivo function of fish TNF is essentially unknown. In this study, we report the identification o...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2015.10.010

    authors： Li MF,Zhang J

    更新日期：2016-02-01 00:00:00

  • The amphibian (Xenopus laevis) colony-stimulating factor-1 and interleukin-34-derived macrophages possess disparate pathogen recognition capacities.

    abstract：:Pathogens such as the Frog Virus 3 (FV3) ranavirus are contributing to the worldwide amphibian declines. While amphibian macrophages (Mϕs) are central to the immune defenses against these viruses, the pathogen recognition capacities of disparate amphibian Mϕ subsets remain unexplored. In turn, Mϕ differentiation and f...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2019.04.011

    authors： Yaparla A,Docter-Loeb H,Melnyk MLS,Batheja A,Grayfer L

    更新日期：2019-09-01 00:00:00

  • Immunological regulation by a β-adrenergic-like octopamine receptor gene in crowded larvae of the oriental Armyworm, Mythmina separata.

    abstract：:Recent reports demonstrate that octopamine plays an important immunological role in crowded larvae of the Oriental Armyworm, Mythmina separata. We identified an octopamine receptor, the β-adrenergic-like gene (designated MsOctβ2R), with a 1191 bp open reading frame that encodes 396 amino acids and contains seven conse...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2020.103802

    authors： Kong H,Yuan L,Dong C,Zheng M,Jing W,Tian Z,Hou Q,Cheng Y,Zhang L,Jiang X,Luo L

    更新日期：2020-12-01 00:00:00

  • Single and mixed-species trypanosome and microsporidia infections elicit distinct, ephemeral cellular and humoral immune responses in honey bees.

    abstract：:Frequently encountered parasite species impart strong selective pressures on host immune system evolution and are more apt to concurrently infect the same host, yet molecular impacts in light of this are often overlooked. We have contrasted immune responses in honey bees to two common eukaryotic endoparasites by estab...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2013.03.010

    authors： Schwarz RS,Evans JD

    更新日期：2013-07-01 00:00:00

  • IL-12 and IL-18 induce interferon-γ production and de novo CD2 expression in porcine γδ T cells.

    abstract：:γδ T cells are highly abundant in the blood and spleen of pigs but little is known about their functional differentiation. In this study the potential of the type-1 polarizing cytokines IL-12 and IL-18 in combination with IL-2 and Concanavalin A (ConA) to stimulate porcine γδ T cells was investigated. Stimulation of p...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2014.07.007

    authors： Sedlak C,Patzl M,Saalmüller A,Gerner W

    更新日期：2014-11-01 00:00:00

  • An ancient and variable mannose-binding lectin from the coral Acropora millepora binds both pathogens and symbionts.

    abstract：:Corals form the framework of the world's coral reefs and are under threat from increases in disease and bleaching (symbiotic dysfunction), yet the mechanisms of pathogen and symbiont recognition remain largely unknown. Here we describe the isolation and characterisation of an ancient mannose-binding lectin in the cora...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2008.05.010

    authors： Kvennefors EC,Leggat W,Hoegh-Guldberg O,Degnan BM,Barnes AC

    更新日期：2008-01-01 00:00:00

  • The genomic structure, alternative splicing and immune response of Chlamys farreri thioester-containing protein.

    abstract：:CfTEP is a member of thioester-containing protein (TEP) family found in Zhikong scallop Chlamys farreri and is involved in innate immunity against invading microbes. In the present study, the genomic DNA of CfTEP was cloned and characterized. The genomic DNA sequence of CfTEP consisted of 40 exons and 39 introns spann...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2009.05.007

    authors： Zhang H,Wang L,Song L,Zhao J,Qiu L,Gao Y,Song X,Li L,Zhang Y,Zhang L

    更新日期：2009-10-01 00:00:00

  • The gene encoding the sea urchin complement protein, SpC3, is expressed in embryos and can be upregulated by bacteria.

    abstract：:Sea urchins have an innate immune response that functions in the absence of adaptive capabilities. It is mediated, in part, by components of the complement system, an important subsystem of the innate response in mammals. A homologue of complement C3, SpC3, has been identified in adult Strongylocentrotus purpuratus an...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(03)00030-2

    authors： Shah M,Brown KM,Smith LC

    更新日期：2003-06-01 00:00:00

  • Teleost contributions to the understanding of mycobacterial diseases.

    abstract：:Few pathogens have shaped human medicine as the mycobacteria. From understanding biological phenomena driving disease spread, to mechanisms of host-pathogen interactions and antibiotic resistance, the Mycobacterium genus continues to challenge and offer insights into the basis of health and disease. Teleost fish model...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2019.02.011

    authors： Hodgkinson JW,Belosevic M,Elks PM,Barreda DR

    更新日期：2019-07-01 00:00:00

  • Encapsulation ability of Drosophila melanogaster: a genetic analysis.

    abstract：:Insects are able to effectively recognize parasitoid eggs or larvae and to eliminate them by formation of a hemocytic capsule. Although the cellular process is now well documented, the genetic aspects of recognition of foreignness and the encapsulation process are still poorly understood. Experiments using the isofema...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(85)90112-0

    authors： Carton Y,Boulétreau M

    更新日期：1985-04-01 00:00:00

  • Molecular characterization and expression analysis of the interleukin 1b gene in Pacific cod (Gadus macrocephalus).

    abstract：:Interleukin 1b (IL-1b) is a member of the cytokine family that serves as major mediators for early pro-inflammatory responses. During artificial breeding of Pacific cod (Gadus macrocephalus), outbreaks of NNV in the early development stages could lead to high mortality. Recent research reported that IL-1b participated...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2018.07.025

    authors： Hu B,Chen B,Mao M,Chen M,Liu X,Cui Q,Liu Y,Jiang C

    更新日期：2018-11-01 00:00:00

  • Activation of immune-associated phospholipase A2 is functionally linked to Toll/Imd signal pathways in the red flour beetle, Tribolium castaneum.

    abstract：:Bacterial challenge enhances phospholipase A(2) (PLA(2)) activity, which in turn induces biosynthesis of various eicosanoids that mediate non-self recognition signal to immune effectors in insects. But, there is little information on how PLA(2) activity is controlled after the non-self recognition. A recent genome ana...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2009.12.013

    authors： Shrestha S,Kim Y

    更新日期：2010-05-01 00:00:00