The gene encoding the sea urchin complement protein, SpC3, is expressed in embryos and can be upregulated by bacteria.

Abstract:

:Sea urchins have an innate immune response that functions in the absence of adaptive capabilities. It is mediated, in part, by components of the complement system, an important subsystem of the innate response in mammals. A homologue of complement C3, SpC3, has been identified in adult Strongylocentrotus purpuratus and is expressed in coelomocytes. In this study, transcript levels from the gene, Sp064, which encodes SpC3, were examined in developing embryos and found to be present in unfertilized eggs and throughout embryogenesis with a peak in transcript levels just prior to and during gastrulation. In addition, continuous exposure of embryos, beginning with the hatched blastula stage, to heat killed Vibrio diazatrophicus, a marine pathogen of sea urchins, significantly increased Sp064 message content in plutei compared to unexposed controls. These results suggest that sea urchin embryos may use a complement-based immune system for defense against pathogens in their aquatic environment.

journal_name

Dev Comp Immunol

authors

Shah M,Brown KM,Smith LC

doi

10.1016/s0145-305x(03)00030-2

keywords:

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

529-38

issue

6-7

eissn

0145-305X

issn

1879-0089

pii

S0145305X03000302

journal_volume

27

pub_type

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