Teleost contributions to the understanding of mycobacterial diseases.

Abstract:

:Few pathogens have shaped human medicine as the mycobacteria. From understanding biological phenomena driving disease spread, to mechanisms of host-pathogen interactions and antibiotic resistance, the Mycobacterium genus continues to challenge and offer insights into the basis of health and disease. Teleost fish models of mycobacterial infections have progressed significantly over the past three decades, now supplying a range of unique tools and new opportunities to define the strategies employed by these Gram-positive bacteria to overcome host defenses, as well as those host antimicrobial pathways that can be used to limit its growth and spread. Herein, we take a comparative perspective and provide an update on the contributions of teleost models to our understanding of mycobacterial diseases.

journal_name

Dev Comp Immunol

authors

Hodgkinson JW,Belosevic M,Elks PM,Barreda DR

doi

10.1016/j.dci.2019.02.011

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

111-125

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(18)30514-7

journal_volume

96

pub_type

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