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TNF induces the growth of thymocytes in rainbow trout.

Abstract：

:In order to investigate the effects of TNFalpha upon the growth of fish thymocytes, rainbow trout thymocytes were cultured in the conditioned medium (CM): the supernatants of the macrophage cultures stimulated with chitin derivative and LPS. Synthesis of TNFalpha by macrophages and subsequent secretion into CM were ascertained by RT-PCR and western blotting. While most of the thymocytes cultured in normal medium died within 7 days, the thymocytes cultured in CM exhibited markedly better growth as monitored by alamarBlue assay and BrdU assay. The proliferating cells appeared to be small lymphocytes. Since such activity in CM was significantly inhibited by an anti-trout TNF antibody, it was clearly evident that TNFalpha in the CM induced the proliferation of the thymocytes. Production of TNFalpha in the thymus of healthy fish was also demonstrated by RT-PCR. Collectively, this data suggest that TNFalpha is involved in T cell development in the trout thymus.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Hino K,Nakamura O,Yoshiura Y,Suetake H,Suzuki Y,Watanabe T

doi

10.1016/j.dci.2005.09.005

keywords:

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

639-47

issue

7

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(05)00189-8

journal_volume

30

pub_type

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