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The two Cg-timp mRNAs expressed in oyster hemocytes are generated by two gene families and differentially expressed during ontogenesis.

Abstract：

:We previously characterized a Crassostrea gigas tissue inhibitor of metalloproteinase (Cg-timp 1.3) with potential role in wound healing and defense mechanisms. Here we isolated a second cDNA (Cg-timp 1.1) encoding a protein that contains the characteristic signature of TIMP proteins. Sequence analysis of the two transcripts showed that they originate from two distinct genes. The two proteins, Cg-TIMP 1.1 and 1.3, are closely related and share 81% identity. Northern blot analysis of Cg-timp gene expression in adult oyster hemocytes indicated that the ratio between the two transcripts was constant from one oyster to another (Cg-timp 1.1 and 1.3 represent 32 and 68%, respectively). Conversely, during ontogenesis the expression pattern of the two Cg-timp genes was different. Indeed, Cg-timp 1.3 mRNAs were detected from the larval D stage whereas Cg-timp 1.1 transcripts were undetectable up to 22 days post-fertilization. The difference in expression pattern of the two Cg-timp genes may reveal distinct implications of these genes in the embryos and larvae developments.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Montagnani C,Tirape A,Boulo V,Escoubas JM

doi

10.1016/j.dci.2005.02.005

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

831-9

issue

10

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(05)00042-X

journal_volume

29

pub_type

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