Abstract：
:Dynamics of leucocyte infiltration and bacterial invasion in the caecal wall were studied after oral infection of 2-day-old chicks with Salmonella enterica ser. Enteritidis. Bacteria invaded the lamina propria of the caecal wall from 12h post-challenge onwards. Bacteriological examination of internal organs (liver, spleen) showed a peak in Salmonella bacteria at 3days post-infection, after which the number of bacteria decreased. Immunohistochemistry revealed macrophages and T-lymphocytes invading the caecal propria mucosae from 24h after challenge onwards, while B-lymphocytes came somewhat later, subsequently organising into follicular aggregates. An early increase in granulocytes was partly masked by the response to natural flora. While the B-lymphocyte and granulocyte populations were maintained, T-lymphocyte and macrophage populations were already reducing by 10days post-challenge. The infiltration of macrophages and T-lymphocytes in the caecal wall, followed by B-lymphocytes, is the result of an inflammatory response, caused by invading bacteria at this site. The structural maturation of the mucosa-associated lymphoid tissues is antigen driven, since B-cells organise in a follicular pattern.
journal_name
Dev Comp Immunoljournal_title
Developmental and comparative immunologyauthors
Van Immerseel F,De Buck J,De Smet I,Mast J,Haesebrouck F,Ducatelle Rdoi
10.1016/s0145-305x(01)00084-2keywords:
subject
Has Abstractpub_date
2002-05-01 00:00:00pages
355-64issue
4eissn
0145-305Xissn
1879-0089pii
S0145305X01000842journal_volume
26pub_type
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