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Ontogeny of CTX expression in xenopus.

Abstract：

:In Xenopus, the type I transmembrane protein, CTX (cortical thymocyte-specific antigen of Xenopus), is hypothesized to play a role in thymocyte differentiation and/or thymic selection. The present studies were undertaken to gather additional evidence in support of a postulated association of CTX with a differentiation step of a cell population that corresponds to the murine immature double positive (CD4+CD8+TCR+) thymocyte subset. During ontogeny, cell surface expression of CTX on thymocytes can first be detected by immunocytochemistry and flow cytometry at 8 days post-fertilization, about 1 day after CD8+ cells first appear. By 12 days post-fertilization, T-cells in the entire cortex except for the outer most layer of cells, are intensely CTX positive, whereas those in the medulla are negative. This pattern persists throughout larval and postmetamorphic life.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Robert J,Cohen N

doi

10.1016/s0145-305x(98)00028-7

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

605-12

issue

5-6

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(98)00028-7

journal_volume

22

pub_type

杂志文章

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