当前位置： SCI文献检索 > DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY期刊下所有文献 > Combinational recognition of bacterial lipoproteins and peptidoglycan by chicken Toll-like receptor 2 subfamily.

Combinational recognition of bacterial lipoproteins and peptidoglycan by chicken Toll-like receptor 2 subfamily.

Abstract：

:Human Toll-like receptor 2 (TLR2) subfamily recognizes bacterial lipoproteins (BLP) and peptidoglycan (PGN). According to the genome information, chicken has structural orthologs of TLRs1 and 2, in addition to TLRs3, 4, 5 and 7. Chicken has two additional TLRs, TLR15 and TLR21, whose orthologs human lacks. The chicken (ch)TLR1 and 2 genes are individually duplicated to encode for four different proteins, chTLR1-1, 1-2, 2-1 and 2-2, of the TLR2 subfamily. Here we investigated the functional profile of these TLR2 subfamily proteins of chicken. By NF-kappaB reporter assay using HEK293 cells, we found that chTLR2-1 and chTLR1-2 cooperatively signal the presence of PGN. A combination of chTLR2-1 and chTLR1-2 also most efficiently recognized diacylated BLP, macrophage-activating lipopeptide 2kDa (Malp-2), while the combination of chTLR2-1 and chTLR1-1 failed to recognize Malp-2. All combinations, however, recognized triacylated BLP, Pam3. Consistent with these results, human TLR2-stimulating mycobacteria preparations, BCG-cell wall and cell lysate of Mycobacterium avium, induced activation of NF-kappaB in cells expressing chTLR2-1 and 1-2 and to lesser extents, cells with chTLR2-2 and either of chTLR1. Strikingly, expression of either of these alone did not activate the reporter for NF-kappaB. These chTLRs are likely to have the combination functional feature as in the human TLR2 subfamily. Confocal and immunoprecipitation analyses of human cell transfectants showed that they cluster on the cell surface by a physical molecular association, causing all of them to merge and coprecipitate. These results suggest that chTLR2 subfamily members discriminate between their ligands by combinational events.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Higuchi M,Matsuo A,Shingai M,Shida K,Ishii A,Funami K,Suzuki Y,Oshiumi H,Matsumoto M,Seya T

doi

10.1016/j.dci.2007.05.003

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

147-55

issue

2

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(07)00080-8

journal_volume

32

pub_type

杂志文章

相关文献

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY文献大全
  • Molecular and functional characterisation of a mannose-binding lectin-like gene from Japanese sea bass (Lateolabrax japonicus).

    abstract：:Mannose-binding lectin (MBL) plays an important role in host immune responses against pathogens. LjMBL-like-1 was identified from Japanese sea bass (Lateolabrax japonicas), which has selectivity for galactose. Herein, this lectin might be better designated as galactose-binding lectin (LjGalBL-1). LjGalBL-1 transcripts...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2019.103558

    authors： Dang Y,Nie L,Chen J

    更新日期：2020-03-01 00:00:00

  • Mucosal immunoglobulins and B cells of teleost fish.

    abstract：:As physical barriers that separate teleost fish from the external environment, mucosae are also active immunological sites that protect them against exposure to microbes and stressors. In mammals, the sites where antigens are sampled from mucosal surfaces and where stimulation of naïve T and B lymphocytes occurs are k...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2011.11.009

    authors： Salinas I,Zhang YA,Sunyer JO

    更新日期：2011-12-01 00:00:00

  • Molecular and functional characterization of a mannose-binding lectin/ficolin-associated protein (MAp44) from Nile tilapia (Oreochromis niloticus) involved in the immune response to bacterial infection.

    abstract：:The lectin pathway of the complement system has a pivotal role in the defense against infectious organisms. Mannose-binding lectin/ficolin-associated protein (MAp44), a multifunctional complement regulator, regulates the complement activation by competing with MASP-1, MASP-2 and MASP-3 for MBL and ficolin binding site...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2019.103438

    authors： Mu L,Wu H,Han K,Wu L,Bian X,Li B,Guo Z,Yin X,Ye J

    更新日期：2019-12-01 00:00:00

  • Innate immune response in the hemolymph of an ascidian, Halocynthia roretzi, showing soft tunic syndrome, using label-free quantitative proteomics.

    abstract：:Soft tunic syndrome of Halocynthia roretzi manifests as soft, weak, and rupturable tunics, causing mass mortality. Utilizing liquid chromatography-tandem mass spectrometry (LC-MS/MS), innate immune response was established by comparing hemolymph protein profiles of ascidians with healthy or softened tunics. Of 100 pro...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2011.01.011

    authors： Cha IS,Castillo CS,Nho SW,Hikima J,Aoki T,Jung TS

    更新日期：2011-08-01 00:00:00

  • Localization of anti-lipopolysaccharide factor (ALFPm3) in tissues of the black tiger shrimp, Penaeus monodon, and characterization of its binding properties.

    abstract：:Anti-lipopolysaccharide factor (ALF) is an antimicrobial peptide originally identified from horseshoe crabs and recently found in several shrimp species. ALFPm3, the most abundant isoform in the black tiger shrimp, Penaeus monodon, has been shown to possess a broad spectrum of antimicrobial activity against Gram-negat...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2008.03.008

    authors： Somboonwiwat K,Bachère E,Rimphanitchayakit V,Tassanakajon A

    更新日期：2008-01-01 00:00:00

  • Molecular cloning and characterisation of chicken IL-18 binding protein.

    abstract：:The human IL-1 receptor family is comprised of 11 membrane bound or soluble receptors and the IL-18 binding protein (IL-18BP). These receptors are dispersed across seven genomic loci, with the majority at a single locus. Direct orthologues were identified in the chicken at conserved genomic loci; however, the IL-18BP ...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2020.103850

    authors： Gibson MS,Steyn A,Kealy D,Kaspers B,Fife MS

    更新日期：2021-01-01 00:00:00

  • Two prophenoloxidases are important for the survival of Vibrio harveyi challenged shrimp Penaeus monodon.

    abstract：:Phenoloxidase (PO) plays an important role in arthropod melanization. Previously, a prophenoloxidase (PmproPO1) gene was cloned and characterized from the hemocytes of the black tiger shrimp, Penaeus monodon. In the present study, we report a novel proPO gene (PmproPO2) belonging to the proPO family identified from th...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2008.09.003

    authors： Amparyup P,Charoensapsri W,Tassanakajon A

    更新日期：2009-02-01 00:00:00

  • Exploring the relationships between amphibian (Xenopus laevis) myeloid cell subsets.

    abstract：:The differentiation of distinct leukocyte subsets is governed by lineage-specific growth factors that elicit disparate expression of transcription factors and markers by the developing cell populations. For example, macrophages (Mφs) and granulocytes (Grns) arise from common granulocyte-macrophage progenitors in respo...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2020.103798

    authors： Yaparla A,Koubourli DV,Popovic M,Grayfer L

    更新日期：2020-12-01 00:00:00

  • Serpin-15 from Bombyx mori inhibits prophenoloxidase activation and expression of antimicrobial peptides.

    abstract：:Serine protease inhibitors (SPIs) play a key role in physiological responses by controlling protease activities. In this study, we studied the biochemical functions of serpin-15, an SPI, from Bombyx mori (Bmserpin-15). Recombinant Bmserpin-15 was expressed in Escherichia coli cells and used to raise rabbit anti-Bmserp...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2015.02.013

    authors： Liu D,Wang L,Yang L,Qian C,Wei G,Dai L,Li J,Zhu B,Liu C

    更新日期：2015-07-01 00:00:00

  • Characterization and antiviral activity of a newly identified defensin-like peptide, HEdefensin, in the hard tick Haemaphysalis longicornis.

    abstract：:Tick defensins are antimicrobial peptides that play a major role in the innate immunity of ticks by providing a direct antimicrobial defense. In this study, we identified and characterized a defensin-like encoding gene, HEdefensin, from the expressed sequence tags (EST) database of hemolymph from the hard tick Haemaph...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2016.11.013

    authors： Talactac MR,Yada Y,Yoshii K,Hernandez EP,Kusakisako K,Maeda H,Galay RL,Fujisaki K,Mochizuki M,Tanaka T

    更新日期：2017-03-01 00:00:00

  • Investigations on the role of a lysozyme from the malaria vector Anopheles dirus during malaria parasite development.

    abstract：:A cDNA encoding a lysozyme was obtained by rapid amplification of cDNA ends-polymerase chain reaction (RACE-PCR) from females of the malaria vector Anopheles dirus A (Diptera: Culicidae). The 623 bp lysozyme (AdLys c-1) cDNA encodes the 120 amino acid mature protein with a predicted molecular mass of 13.4 kDa and theo...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2011.06.010

    authors： Lapcharoen P,Komalamisra N,Rongsriyam Y,Wangsuphachart V,Dekumyoy P,Prachumsri J,Kajla MK,Paskewitz SM

    更新日期：2012-01-01 00:00:00

  • Characterization of the circulating hemocytes in mud crab (Scylla olivacea) revealed phenoloxidase activity.

    abstract：:This study focused on an isolation and characterization of the circulating hemocytes in mud crab, Scylla olivacea. Isolation of specific cell types of hemocytes from crab hemolymph was accomplished by using 60% Percoll density gradient centrifugation. Four separated bands of the hemocytes were successfully obtained. C...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2013.11.018

    authors： Mangkalanan S,Sanguanrat P,Utairangsri T,Sritunyalucksana K,Krittanai C

    更新日期：2014-05-01 00:00:00

  • Heat shock protein 70 (HSP70) promotes air exposure tolerance of Litopenaeus vannamei by preventing hemocyte apoptosis.

    abstract：:Brief pretreatment of cold shock at 13 °C for 3 min proved to be an inducer of heat shock protein 70 (HSP70) and improved stress tolerance as a molecular chaperone. With the improvement of air exposure tolerance, HSP70 in shrimp hemocytes was upregulated in mRNA and protein levels after cold shock. Both HSP70 RNA inte...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2020.103844

    authors： Guan W,Wei X,Nong W,Shao Y,Mao L

    更新日期：2021-01-01 00:00:00

  • The first report of siglec-3/CD33 gene in a teleost (rock bream, Oplegnathus fasciatus): An analysis of its spatial expression during stimulation to red seabream iridovirus (RSIV) and two bacterial pathogens.

    abstract：:Siglec-3/CD33 is a myeloid-specific inhibitory receptor that is expressed on cells of the immune system, where it is believed to play a regulatory role, modulating the inflammatory and immune responses. We characterized CD33 (RbCD33) in rock bream which is a transmembrane protein with two IG-like domains and a cytopla...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2018.02.005

    authors： Jeswin J,Joo MS,Jeong JM,Bae JS,Choi KM,Cho DH,Park SI,Park CI

    更新日期：2018-07-01 00:00:00

  • Encapsulation ability of Drosophila melanogaster: a genetic analysis.

    abstract：:Insects are able to effectively recognize parasitoid eggs or larvae and to eliminate them by formation of a hemocytic capsule. Although the cellular process is now well documented, the genetic aspects of recognition of foreignness and the encapsulation process are still poorly understood. Experiments using the isofema...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(85)90112-0

    authors： Carton Y,Boulétreau M

    更新日期：1985-04-01 00:00:00

  • Cell type-specific differences in β-glucan recognition and signalling in porcine innate immune cells.

    abstract：:β-glucans exert receptor-mediated immunomodulating activities, including oxidative burst activity and cytokine secretion. The role of the β-glucan receptors dectin-1 and complement receptor 3 (CR3) in the response of immune cells towards β-glucans is still unresolved. Dectin-1 is considered as the main β-glucan recept...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2014.10.005

    authors： Baert K,Sonck E,Goddeeris BM,Devriendt B,Cox E

    更新日期：2015-01-01 00:00:00

  • Swine leukocyte antigen (SLA) diversity in Sinclair and Hanford swine.

    abstract：:The swine leukocyte antigen (SLA) haplotype B is associated with increased penetrance of the tumor traits in Sinclair swine cutaneous melanoma (SSCM). We established a series of SinclairxHanford swine crosses to facilitate genetic mapping of the tumor-associated loci. In this study, the SLA diversity in the founding a...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2009.09.006

    authors： Ho CS,Martens GW,Amoss MS Jr,Gomez-Raya L,Beattie CW,Smith DM

    更新日期：2010-03-01 00:00:00

  • Chronic hyperosmotic stress inhibits renal Toll-Like Receptors expression in striped catfish (Pangasianodon hypophthalmus, Sauvage) exposed or not to bacterial infection.

    abstract：:Toll-like Receptors (TLRs) are the first innate receptors in recognizing pathogen-associated molecular patterns. In fish, upregulation of toll-like receptors during infection has been largely demonstrated while the effects of abiotic stressors on their expression remain poorly investigated. In this study, striped catf...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2017.03.020

    authors： Schmitz M,Baekelandt S,Bequet S,Kestemont P

    更新日期：2017-08-01 00:00:00

  • Trypanosoma cruzi is lysed by coelomic cytolytic factor-1, an invertebrate analogue of tumor necrosis factor, and induces phenoloxidase activity in the coelomic fluid of Eisenia foetida foetida.

    abstract：:A cytolytic protein named Coelomic Cytolytic Factor-1 (CCF-1) was isolated from the coelomic fluid of the earthworm Eisenia foetida foetida. Despite the absence of any gene homology, CCF-1 showed functional analogy with the mammalian cytokine tumour necrosis factor (TNF), particularly based on similar lectin-like acti...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(01)00048-9

    authors： Olivares Fontt E,Beschin A,Van Dijck E,Vercruysse V,Bilej M,Lucas R,De Baetselier P,Vray B

    更新日期：2002-01-01 00:00:00

  • The molecular evolution of the interleukin-1 family of cytokines; IL-18 in teleost fish.

    abstract：:The cytokine network is an important homeostatic system with potent activities in immune surveillance, growth, developmental and repair processes. Although interleukin-1beta (IL-1beta) is considered a pivotal pro-inflammatory cytokine, merely focussing on its inflammatory role would be too narrow an approach. Elucidat...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2003.09.005

    authors： Huising MO,Stet RJ,Savelkoul HF,Verburg-van Kemenade BM

    更新日期：2004-05-03 00:00:00

  • The Drosophila Thioester containing Protein-4 participates in the induction of the cellular immune response to the pathogen Photorhabdus.

    abstract：:The function of thioester-containing proteins (TEPs) in the immune defense of the fruit fly Drosophila melanogaster is yet mostly unexplored. Recently, we showed the involvement of TEP4 in the activation of humoral and phenoloxidase immune responses of Drosophila against the pathogenic bacteria Photorhabdus luminescen...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2017.06.008

    authors： Shokal U,Eleftherianos I

    更新日期：2017-11-01 00:00:00

  • A bifunctional invertebrate-type lysozyme from the disk abalone, Haliotis discus discus: genome organization, transcriptional profiling and biological activities of recombinant protein.

    abstract：:Lysozyme is an important enzyme in the innate immune system that plays a vital role in fighting microbial infections. In the current study, we identified, cloned, and characterized a gene that encodes an invertebrate-type lysozyme from the disk abalone, Haliotis discus discus (abLysI). The full-length cDNA of abLysI c...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2013.06.009

    authors： Bathige SD,Umasuthan N,Kasthuri SR,Whang I,Lim BS,Nam BH,Lee J

    更新日期：2013-10-01 00:00:00

  • HSP70 gene expression in Mytilus galloprovincialis hemocytes is triggered by moderate heat shock and Vibrio anguillarum, but not by V. splendidus or Micrococcus lysodeikticus.

    abstract：:Complete sequence of HSP70 cDNA from the mussel, Mytilus galloprovincialis was established before quantifying its expression following moderate heat shock or injection of heat-killed bacteria. HSP70 cDNA is comprised of 2378 bp including one ORF of 654 aa, with a predicted 70 bp 5'-UTR and a 343 bp 3'-UTR (GenBank, 18...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2005.12.009

    authors： Cellura C,Toubiana M,Parrinello N,Roch P

    更新日期：2006-01-01 00:00:00

  • Characterization of serum immunoglobulins in a chondrostean fish, Acipenser baeri.

    abstract：:The euglobulin fraction of sturgeon (Acipenser baeri) serum was analyzed using electrophoretic and immunoblotting techniques. The major protein of this fraction is an IgM-like molecule composed of equimolar 70-kDa glycosylated H chains and 26-30 kDa L chains. In the absence of a reducing agent, the L and H polypeptide...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(05)80007-2

    authors： Partula S,Charlemagne J

    更新日期：1993-11-01 00:00:00

  • Identification and characterization of an amphioxus matrix metalloproteinase homolog BbMMPL2 responding to bacteria challenge.

    abstract：:Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases mainly involved in extracellular matrix (ECM) degradation. We have cloned and identified BbMMPL2 as homolog of MMPs from adult amphioxus. Recombinant BbMMPL2 proteins underwent self-processing during refolding in vitro. The final ~23 kDa po...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2012.02.015

    authors： Zhang Y,Zhang H,Kong Y,Feng L

    更新日期：2012-07-01 00:00:00

  • Morphine affects the inflammatory response in carp by impairment of leukocyte migration.

    abstract：:Opioid peptides are evolutionary conserved and in teleost fish their specific receptor types have been identified not only on neuroendocrine cells but also on immunocytes. In the present work we have studied the effects of morphine, ligand for the mu3 opioid receptor, on innate immune responses of common carp. Both in...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2008.07.004

    authors： Chadzinska M,Savelkoul HF,Verburg-van Kemenade BM

    更新日期：2009-01-01 00:00:00

  • Anopheles gambiae hemocytes exhibit transient states of activation.

    abstract：:Hemocytes are crucial players of the mosquito immune system and critically affect transmission of pathogens including malaria parasites. We and others discovered previously that a blood meal is a major immune stimulus for mosquito hemocytes. To determine whether these blood meal-induced hemocyte changes in Anopheles g...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2015.10.020

    authors： Bryant WB,Michel K

    更新日期：2016-02-01 00:00:00

  • Different sensitivity to the dexamethasone treatment of the lymphoid organs of Rana perezi in two different seasons.

    abstract：:Adult female frogs (Rana perezi) have been used to analyze structural and morphometrical changes which affect lymphoid organs after treatment with a single dose of dexamethasone (DX). Special attention was given to the distinct sensitivity observed during two different periods of the year. Morphological differences we...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(89)90017-7

    authors： Garrido E,Gomariz RP,Leceta J,Zapata A

    更新日期：1989-01-01 00:00:00

  • Phylogeny of lymphocyte heterogeneity. I. Membrane immunoglobulins of teleost lymphocytes.

    abstract：:Immunofluorescence studies of bream lymphoid tissues revealed that our 90% of the lymphocytes from blood, anterior kidney, spleen and thymus exhibited membrane immunoglobulin determinants. Furthermore, a majority of such cells were observed to undergo patching and capping when the membrane proteins were complexed with...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(77)80004-9

    authors： Clem LW,McLean WE,Shankey VT,Cuchens MA

    更新日期：1977-04-01 00:00:00

  • Black carp RIPK1 negatively regulates MAVS-mediated antiviral signaling during the innate immune activation.

    abstract：:Receptor-interacting serine/threonine protein kinase 1 (RIPK1) is an important regulator of necroptosis and involved in innate immune response in human and mammal; however, its function in teleost fish mains largely unknown. In this paper, the RIPK1 homologue of black carp (Mylopharyngodon piceus) has been cloned and ...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2020.103726

    authors： Xie X,Cao Y,Dai Y,Chen Z,Wei J,Tan Y,Wu H,Feng H

    更新日期：2020-08-01 00:00:00