当前位置： SCI文献检索 > DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY期刊下所有文献 > Cell type-specific differences in β-glucan recognition and signalling in porcine innate immune cells.

Cell type-specific differences in β-glucan recognition and signalling in porcine innate immune cells.

Abstract：

:β-glucans exert receptor-mediated immunomodulating activities, including oxidative burst activity and cytokine secretion. The role of the β-glucan receptors dectin-1 and complement receptor 3 (CR3) in the response of immune cells towards β-glucans is still unresolved. Dectin-1 is considered as the main β-glucan receptor in mice, while recent studies in man show that CR3 is more important in β-glucan-mediated responses. This incited us to elucidate which receptor contributes to the response of innate immune cells towards particulate β-glucans in pigs as the latter might serve as a better model for man. Our results show an important role of CR3 in β-glucan recognition, as blocking this receptor strongly reduced the phagocytosis of β-glucans and the β-glucan-induced ROS production by porcine neutrophils. Conversely, dectin-1 does not seem to play a major role in β-glucan recognition in neutrophils. However, recognition of β-glucans appeared cell type-specific as both dectin-1 and CR3 are involved in the β-glucan-mediated responses in pig macrophages. Moreover, CR3 signalling through focal adhesion kinase (FAK) was indispensable for β-glucan-mediated ROS production and cytokine production in neutrophils and macrophages, while the Syk-dependent pathway was only partly involved in these responses. We may conclude that CR3 plays a cardinal role in β-glucan signalling in porcine neutrophils, while macrophages use a more diverse receptor array to detect and respond towards β-glucans. Nonetheless, FAK acts as a master switch that regulates β-glucan-mediated responses in neutrophils as well as macrophages.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Baert K,Sonck E,Goddeeris BM,Devriendt B,Cox E

doi

10.1016/j.dci.2014.10.005

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

192-203

issue

1

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(14)00252-3

journal_volume

48

pub_type

杂志文章

相关文献

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY文献大全
  • In silico analysis of Schmidtea mediterranea TIR domain-containing proteins.

    abstract：:While genetic evidence points towards an absence of Toll-Like Receptors (TLRs) in Platyhelminthes, the Toll/IL-1 Receptor (TIR)-domains that drive the assembly of signalling complexes downstream TLR are present in these organisms. Here, we undertook the characterisation of the repertoire of TIR-domain containing prote...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2018.05.004

    authors： Tsoumtsa LL,Sougoufara S,Torre C,Lemichez E,Pontarotti P,Ghigo E

    更新日期：2018-09-01 00:00:00

  • Identification of a novel antimicrobial peptide from the sea star Patiria pectinifera.

    abstract：:Antimicrobial peptides (AMPs) are components of innate immunity found in many forms of life. However, there have been no reports of AMPs in sea star (Phylum Echinodermata). Here we report the isolation and characterization of a novel antimicrobial peptide from the coelomic epithelium extract of the sea star Patiria pe...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2018.05.002

    authors： Kim CH,Go HJ,Oh HY,Park JB,Lee TK,Seo JK,Elphick MR,Park NG

    更新日期：2018-09-01 00:00:00

  • The bovine genomic DNA sequence data reveal three IGHV subgroups, only one of which is functionally expressed.

    abstract：:A comprehensive analysis of cattle shotgun sequencing data reveals 36 immunoglobulin heavy chain variable genes. The previously described bovine subgroup IGHV1 contains 10 functional genes with a conserved promoter including the consensus octamer and several other transcription factor binding sites, intact exons and m...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2012.02.006

    authors： Niku M,Liljavirta J,Durkin K,Schroderus E,Iivanainen A

    更新日期：2012-07-01 00:00:00

  • Lipopolysaccharide- and β-1,3-glucan-binding protein from Fenneropenaeus merguiensis functions as a pattern recognition receptor with a broad specificity for diverse pathogens in the defense against microorganisms.

    abstract：:In crustaceans, lipopolysaccharide- and β-1,3-glucan-binding protein (LGBP) plays an important role in innate immunity by mediating the recognition of pathogens to host cells. Hereby, LGBP was cloned from Fenneropenaeus merguiensis hepatopancreas. Its full-length cDNA (1280 bp) had an open reading frame of 1101 bp, en...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2016.07.006

    authors： Chaosomboon A,Phupet B,Rattanaporn O,Runsaeng P,Utarabhand P

    更新日期：2017-02-01 00:00:00

  • Purification and properties of agglutinins from conger eel, Conger Myriaster (Brevoort), skin mucus.

    abstract：:The skin mucus of the conger eel, Conger myriaster, contains galactose-specific agglutinins. Hemagglutinating activity is independent of divalent cations and is destroyed by heating at 50 degrees C for 15 min. The mucus agglutinins, named congerins, are a mixture of proteins with different electrical charges. Three of...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(88)90007-9

    authors： Kamiya H,Muramoto K,Goto R

    更新日期：1988-04-01 00:00:00

  • CMPK2 of triploid crucian carp is involved in immune defense against bacterial infection.

    abstract：:Cytidine/uridine monophosphate kinase 2 (CMPK2) is a thymidylate kinase and in mammals is known to be involved in mitochondrial DNA (mtDNA) synthesis and antiviral immunity. However, very little is known about the function of CMPK2 in fish. With an aim to elucidate the antimicrobial mechanism of CMPK2 in fish, we in t...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2020.103924

    authors： Feng C,Tang Y,Liu X,Zhou Z

    更新日期：2021-03-01 00:00:00

  • A class B scavenger receptor mediates antimicrobial peptide secretion and phagocytosis in Chinese mitten crab (Eriocheir sinensis).

    abstract：:Scavenger receptors (SRs) are pattern recognition receptors (PRRs) vital for innate immunity. As well as their importance in immune recognition, microbe phagocytosis, and the clearance of modified endogenous molecules, they also activate downstream immune responses as co-receptors. In the current study, we identified ...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2019.103496

    authors： Tang M,Li X,Yang L,Wang Q,Li W

    更新日期：2020-02-01 00:00:00

  • Characterization of CD3γ/δ+ cells in grass carp (Ctenopharyngodon idella).

    abstract：:CD3 is an essential component of the TCR-CD3 complex which plays a key role in adaptive immunity. Non-mammalian CD3 complex consists of CD3γ/δ, CD3ε and CD3ζ subunits. In this study, homologues of CD3γ/δ and CD3ε (termed CiCD3γ/δ and CiCD3ε) have been identified in grass carp (Ctenopharyngodon idella). Like their coun...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2020.103791

    authors： Qin Y,Sun Z,Wang W,Xu J,Wang B,Jia Z,Li X,Wang J,Gao Q,Chen X,Zou J

    更新日期：2021-01-01 00:00:00

  • Lipopolysaccharide activates the sea urchin immune system.

    abstract：:Profilin is a small, actin-binding protein that functions at the intersection of signal transduction and cytoskeletal modifications. Increases in the number of profilin messages per cell correlate with sea urchin coelomocytes activation in response to injury. Here we show that coelomocytes respond to immune challenge ...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(95)00009-i

    authors： Smith LC,Britten RJ,Davidson EH

    更新日期：1995-05-01 00:00:00

  • Panusin represents a new family of β-defensin-like peptides in invertebrates.

    abstract：:Beta_defensin have been solely found in vertebrates until β-defensin-like peptides were described as transcript isoforms in two species of Panulirus genus. They were considered as putative antimicrobials since their biological activity have not been demonstrated. Here we purified and characterized a defensin-like pept...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2016.09.002

    authors： Montero-Alejo V,Corzo G,Porro-Suardíaz J,Pardo-Ruiz Z,Perera E,Rodríguez-Viera L,Sánchez-Díaz G,Hernández-Rodríguez EW,Álvarez C,Peigneur S,Tytgat J,Perdomo-Morales R

    更新日期：2017-02-01 00:00:00

  • Expression and functional characterization of interferon regulatory factors (irf2, irf7 and irf9) in the blunt snout bream (Megalobrama amblycephala).

    abstract：:Interferon regulatory factors (irfs) are a family of genes that encode transcription factors with important roles in regulating the expression of Type I interferons (IFNs) and other genes associated with related pathways. irfs have multitudinous functions in growth, development and regulation of oncogenesis. In this s...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2016.09.014

    authors： Zhan FB,Liu H,Lai RF,Jakovlić I,Wang WM

    更新日期：2017-02-01 00:00:00

  • Characterization and antiviral activity of a newly identified defensin-like peptide, HEdefensin, in the hard tick Haemaphysalis longicornis.

    abstract：:Tick defensins are antimicrobial peptides that play a major role in the innate immunity of ticks by providing a direct antimicrobial defense. In this study, we identified and characterized a defensin-like encoding gene, HEdefensin, from the expressed sequence tags (EST) database of hemolymph from the hard tick Haemaph...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2016.11.013

    authors： Talactac MR,Yada Y,Yoshii K,Hernandez EP,Kusakisako K,Maeda H,Galay RL,Fujisaki K,Mochizuki M,Tanaka T

    更新日期：2017-03-01 00:00:00

  • Hemolin-A lepidopteran anti-viral defense factor?

    abstract：:Immunity in insects has largely focused on responses towards bacteria and fungi, but recently the study of immune responses against viral infections has also received attention. In Lepidoptera, phagocytosis and encapsulation mediated by hemocytes, and apoptosis are part of the response against virus infection; however...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2007.09.006

    authors： Terenius O

    更新日期：2008-01-01 00:00:00

  • To complete its replication cycle, a shrimp virus changes the population of long chain fatty acids during infection via the PI3K-Akt-mTOR-HIF1α pathway.

    abstract：:White spot syndrome virus (WSSV), the causative agent of white spot disease (WSD), is a serious and aggressive shrimp viral pathogen with a worldwide distribution. At the genome replication stage (12 hpi), WSSV induces a metabolic rerouting known as the invertebrate Warburg effect, which boosts the availability of ene...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2015.06.001

    authors： Hsieh YC,Chen YM,Li CY,Chang YH,Liang SY,Lin SY,Lin CY,Chang SH,Wang YJ,Khoo KH,Aoki T,Wang HC

    更新日期：2015-11-01 00:00:00

  • Cloning of the IL-1β3 gene and IL-1β4 pseudogene in salmonids uncovers a second type of IL-1β gene in teleost fish.

    abstract：:To date two closely related interleukin-1β genes (IL-1β1 and IL-β2) have been found in salmonids. The cloning of trout and salmon IL-1β3, and a salmon IL-1β4 pseudogene reveals that two types of IL-1β genes exist in teleost species. Type I teleost IL-1β genes, including salmonid IL-1β3, share a similar 6 coding exon s...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2012.07.010

    authors： Husain M,Bird S,van Zwieten R,Secombes CJ,Wang T

    更新日期：2012-11-01 00:00:00

  • Cloning of Litopenaeus vannamei CD63 and it's role in white spot syndrome virus infection.

    abstract：:White Spot Syndrome Virus (WSSV) is currently the most serious shrimp pathogen, which has brought huge losses to shrimp industry worldwide. CD63 of shrimp belongs to the tetraspanin superfamily, which plays an important role in signal transduction and immune process. In this paper, CD63 cDNA sequence of Litopenaeus va...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2016.03.004

    authors： Guan GK,Liu QH,Li C,Huang J

    更新日期：2016-07-01 00:00:00

  • Temperature-mediated processes in teleost immunity: differential effects of in vitro and in vivo temperatures on mitogenic responses of channel catfish lymphocytes.

    abstract：:The in vitro mitogenic responses of channel catfish peripheral blood leucocytes to ConA and LPS were differentially affected by both in vitro and in vivo temperatures. The magnitude of the response to LPS was relatively independent of both in vitro culture temperature and in vivo acclimation temperature. The magnitude...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(84)90038-7

    authors： Clem LW,Faulmann E,Miller NW,Ellsaesser C,Lobb CJ,Cuchens MA

    更新日期：1984-04-01 00:00:00

  • Trypanosoma carassii hsp70 increases expression of inflammatory cytokines and chemokines in macrophages of the goldfish (Carassius auratus L.).

    abstract：:We report on the cloning and characterization of Trypanosoma carassii 70 KDa heat shock protein (hsp70). T. carassii hsp70 was secreted/excreted into culture medium in vitro and was recognized by sera from infected fish. Recombinant hsp70 (rhsp70) activated goldfish macrophages and stimulated the production of pro-inf...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2009.06.003

    authors： Oladiran A,Belosevic M

    更新日期：2009-10-01 00:00:00

  • Changes in Caenorhabditis elegans gene expression following exposure to Photorhabdus luminescens strain TT01.

    abstract：:Photorhabdus bacteria enter into a mutualistic symbiosis with Heterorhabditis nematodes to infect insect larvae. However, they rapidly kill the model nematode Caenorhabditis elegans. One hypothesis for these divergent outcomes is that the nematode defense responses differ. To begin testing this hypothesis, we have sys...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2017.09.005

    authors： Hoinville ME,Wollenberg AC

    更新日期：2018-05-01 00:00:00

  • The genomic structure, alternative splicing and immune response of Chlamys farreri thioester-containing protein.

    abstract：:CfTEP is a member of thioester-containing protein (TEP) family found in Zhikong scallop Chlamys farreri and is involved in innate immunity against invading microbes. In the present study, the genomic DNA of CfTEP was cloned and characterized. The genomic DNA sequence of CfTEP consisted of 40 exons and 39 introns spann...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2009.05.007

    authors： Zhang H,Wang L,Song L,Zhao J,Qiu L,Gao Y,Song X,Li L,Zhang Y,Zhang L

    更新日期：2009-10-01 00:00:00

  • IL-22 is a key player in the regulation of inflammation in fish and involves innate immune cells and PI3K signaling.

    abstract：:IL-22 plays a role in various disorders in mammals, including mucosal-associated infections and inflammatory diseases. No functional IL-22 studies have been conducted on non-mammals to date. In this study, recombinant IL-22 (rIL-22) from turbot was produced to investigate its effects as a bioactive molecule. The expre...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2013.08.021

    authors： Costa MM,Saraceni PR,Forn-Cuní G,Dios S,Romero A,Figueras A,Novoa B

    更新日期：2013-12-01 00:00:00

  • Partial characterization of chicken spleen cell culture supernatants stimulated with Staphylococcus aureus.

    abstract：:The role of accessory cells in the proliferative response of chicken spleen cells to Staphylococcus aureus Cowan I (SAC) was examined. It was found that chicken spleen cells cultured with SAC produced a soluble molecule capable of causing proliferation when culture supernatants were added to spleen cells. The molecule...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(87)90020-6

    authors： Schoof DD,Tempelis CH

    更新日期：1987-01-01 00:00:00

  • Amiloride-sensitive epithelial sodium channel subunits are expressed in human and mussel immunocytes.

    abstract：:In this study, we examined the expression of epithelial Na(+) channel (ENaC) subunits in human peripheral blood lymphocytes, human lymph nodes and molluscan immunocytes using non-radioactive in situ hybridization. The results showed that T lymphocytes express the ENaC gamma subunit mRNA, and B lymphocytes the ENaC bet...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(01)00097-0

    authors： Ottaviani E,Franchini A,Mandrioli M,Saxena A,Hanukoglu A,Hanukoglu I

    更新日期：2002-06-01 00:00:00

  • Functional studies on Calliphora vomitoria haemocyte subpopulations defined by lectin staining and density centrifugation.

    abstract：:Haemocyte subpopulations of Calliphora vomitoria have been categorized by their surface staining properties using fluorescently labelled lectins, and their mobilities in Percoll density gradients. These methods of identification were exploited to determine the roles of these cell types in cellular defence reactions. S...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(92)90048-h

    authors： McKenzie AN,Preston TM

    更新日期：1992-01-01 00:00:00

  • A bifunctional invertebrate-type lysozyme from the disk abalone, Haliotis discus discus: genome organization, transcriptional profiling and biological activities of recombinant protein.

    abstract：:Lysozyme is an important enzyme in the innate immune system that plays a vital role in fighting microbial infections. In the current study, we identified, cloned, and characterized a gene that encodes an invertebrate-type lysozyme from the disk abalone, Haliotis discus discus (abLysI). The full-length cDNA of abLysI c...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2013.06.009

    authors： Bathige SD,Umasuthan N,Kasthuri SR,Whang I,Lim BS,Nam BH,Lee J

    更新日期：2013-10-01 00:00:00

  • Invertebrate host responses to microsporidia infections.

    abstract：:Microsporidia are a group of fungi-like intracellular and unicellular parasites, which infect nearly all animals. As "master parasites", over 1400 microsporidian species have been described to date. Microsporidia infections in economical invertebrates (e.g., silkworm, shrimp) cause huge financial losses, while other m...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2018.02.004

    authors： Pan G,Bao J,Ma Z,Song Y,Han B,Ran M,Li C,Zhou Z

    更新日期：2018-06-01 00:00:00

  • Gene expression study in Bathymodiolus azoricus populations from three North Atlantic hydrothermal vent sites.

    abstract：:The deep-sea hydrothermal vents are known as harsh environments, abundant in animal diversity surrounded by fluids with specific physiological and chemical composition. Bathymodiolus azoricus mussels are endemic species dwelling at hydrothermal vent sites and at distinct depth ranges. Mussels from Menez Gwen (MG), Luc...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2019.05.001

    authors： Martins E,Bettencourt R

    更新日期：2019-10-01 00:00:00

  • In vivo and in vitro knockdown of FREP2 gene expression in the snail Biomphalaria glabrata using RNA interference.

    abstract：:RNA interference (RNAi) is reported here for the first time for Biomphalaria glabrata, the snail intermediate host for the human parasite Schistosoma mansoni. The fibrinogen-related protein 2 (FREP2) gene, normally expressed at increased levels following exposure to digenetic trematode parasites, such as S. mansoni or...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2005.12.004

    authors： Jiang Y,Loker ES,Zhang SM

    更新日期：2006-01-01 00:00:00

  • White blood cell profiles in amphibians help to explain disease susceptibility following temperature shifts.

    abstract：:Temperature variability, and in particular temperature decreases, can increase susceptibility of amphibians to infections by the fungus Batrachochytrium dendrobatidis (Bd). However, the effects of temperature shifts on the immune systems of Bd-infected amphibians are unresolved. We acclimated frogs to 16 °C and 26 °C ...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2017.08.018

    authors： Greenspan SE,Bower DS,Webb RJ,Berger L,Rudd D,Schwarzkopf L,Alford RA

    更新日期：2017-12-01 00:00:00

  • Antimicrobial peptide defenses against chytridiomycosis, an emerging infectious disease of amphibian populations.

    abstract：:Chytridiomycosis, an emerging infectious disease (EID) of the skin caused by the chytrid fungus, Batrachochytrium dendrobatidis, has been linked with continuing amphibian population declines in the western USA, Central America, Europe, Africa, and Australia. Genetic analysis suggests that B. dendrobatidis is a recentl...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2004.11.004

    authors： Rollins-Smith LA,Conlon JM

    更新日期：2005-01-01 00:00:00