Amiloride-sensitive epithelial sodium channel subunits are expressed in human and mussel immunocytes.

Abstract:

:In this study, we examined the expression of epithelial Na(+) channel (ENaC) subunits in human peripheral blood lymphocytes, human lymph nodes and molluscan immunocytes using non-radioactive in situ hybridization. The results showed that T lymphocytes express the ENaC gamma subunit mRNA, and B lymphocytes the ENaC beta subunit mRNA. Yet, the alpha subunit mRNA was not detected in either cell type. In molluscan immunocytes, all three homologous ENaC subunit mRNAs are present, and these data were also confirmed by RT-PCR and sequencing of the PCR products. These findings show evolutionary conservation of the expression of ENaC subunits in immunocytes of invertebrates to vertebrates. The observed differential expression patterns of ENaC subunits suggest that ENaC function may be regulated differentially in different types of human lymphocytes.

journal_name

Dev Comp Immunol

authors

Ottaviani E,Franchini A,Mandrioli M,Saxena A,Hanukoglu A,Hanukoglu I

doi

10.1016/s0145-305x(01)00097-0

keywords:

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

395-402

issue

5

eissn

0145-305X

issn

1879-0089

pii

S0145305X01000970

journal_volume

26

pub_type

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