Abstract:
:While genetic evidence points towards an absence of Toll-Like Receptors (TLRs) in Platyhelminthes, the Toll/IL-1 Receptor (TIR)-domains that drive the assembly of signalling complexes downstream TLR are present in these organisms. Here, we undertook the characterisation of the repertoire of TIR-domain containing proteins in Schmidtea mediterranea in order to gain valuable information on TLR evolution in metazoan. We report the presence of twenty proteins containing between one and two TIR domains. In addition, our phylogenetic-based reconstruction approach identified Smed-SARM and Smed-MyD88 as conserved TLR adaptors.
journal_name
Dev Comp Immunoljournal_title
Developmental and comparative immunologyauthors
Tsoumtsa LL,Sougoufara S,Torre C,Lemichez E,Pontarotti P,Ghigo Edoi
10.1016/j.dci.2018.05.004subject
Has Abstractpub_date
2018-09-01 00:00:00pages
214-218eissn
0145-305Xissn
1879-0089pii
S0145-305X(18)30107-1journal_volume
86pub_type
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