In silico analysis of Schmidtea mediterranea TIR domain-containing proteins.

Abstract:

:While genetic evidence points towards an absence of Toll-Like Receptors (TLRs) in Platyhelminthes, the Toll/IL-1 Receptor (TIR)-domains that drive the assembly of signalling complexes downstream TLR are present in these organisms. Here, we undertook the characterisation of the repertoire of TIR-domain containing proteins in Schmidtea mediterranea in order to gain valuable information on TLR evolution in metazoan. We report the presence of twenty proteins containing between one and two TIR domains. In addition, our phylogenetic-based reconstruction approach identified Smed-SARM and Smed-MyD88 as conserved TLR adaptors.

journal_name

Dev Comp Immunol

authors

Tsoumtsa LL,Sougoufara S,Torre C,Lemichez E,Pontarotti P,Ghigo E

doi

10.1016/j.dci.2018.05.004

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

214-218

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(18)30107-1

journal_volume

86

pub_type

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