当前位置： SCI文献检索 > DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY期刊下所有文献 > Penaeus vannamei serine proteinase inhibitor 7 (LvSerpin7) acts as an immune brake by regulating the proPO system in AHPND-affected shrimp.

Penaeus vannamei serine proteinase inhibitor 7 (LvSerpin7) acts as an immune brake by regulating the proPO system in AHPND-affected shrimp.

Abstract：

:Acute hepatopancreatic necrosis disease (AHPND) is a recently emerged disease in aqua cultured shrimp that is caused by virulent strains of Vibrio parahaemolyticus (VP). Our previous study used transcriptomics to identify key pathogenic factors in the stomach of AHPND-infected shrimp (Litopenaeus vannamei), and here we used a different subset of the same data to construct a gene-to-gene expression correlation network to identify immune-responsive genes. LvSerpin7 was found to have the highest number of correlations after infection, and it also showed a significant increase in mRNA expression. LvSerpin7 is expressed in all tissues but its expression levels are highest in hemocytes. After successfully silencing LvSerpin7 transcript prior to AHPND challenge, mortality was significantly increased relative to the controls and reached 100% within 36 h post infection. Compared to the controls, the phenoloxidase (PO) activity also increased in both hemolymph and stomach. Recombinant LvSerpin7 inhibited shrimp PO activity in vitro, and we also found that rLvSerpin7 inhibited the growth of AHPND-causing bacteria. These results suggest that LvSerpin7 might reduce the toxic effects that result from unregulated activation of the PO defense system by AHPND-causing bacteria.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Apitanyasai K,Chang CC,Ng TH,Ng YS,Liou JH,Lo CF,Lin SS,Wang HC

doi

10.1016/j.dci.2019.103600

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

103600

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(19)30520-8

journal_volume

106

pub_type

杂志文章

相关文献

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY文献大全
  • Suppression of Salmonella enterica serovar Enteritidis excretion by intraocular vaccination with fimbriae proteins incorporated in liposomes.

    abstract：:Liposome-associated fimbriae antigens (SEF14 and SEF21) were prepared for intraocular immunization to seek protective efficacy for intestinal infection with Salmonella enterica serovar Enteritidis. Chickens were immunized intraocularly with the antigens at 8 and 10 weeks of age. Evidence of an IgA and IgG responses we...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(03)00086-7

    authors： Li W,Watarai S,Iwasaki T,Kodama H

    更新日期：2004-01-01 00:00:00

  • Antimicrobial mechanisms of fish leukocytes.

    abstract：:Early activation and coordination of innate defenses are critical for effective responses against infiltrating pathogens. Rapid engagement of immune cells provides a critical first line of defense soon after pathogen infiltration. Activation leads to a well-orchestrated set of events that sees the induction and regula...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2011.03.009

    authors： Rieger AM,Barreda DR

    更新日期：2011-12-01 00:00:00

  • Variation in expression of Biomphalaria glabrata SOD1: a potential controlling factor in susceptibility/resistance to Schistosoma mansoni.

    abstract：:The snail Biomphalaria glabrata kills the blood fluke Schistosoma mansoni by a mechanism involving production of hydrogen peroxide, the enzymatic product of cytosolic Cu/Zn superoxide dismutase (SOD1). This enzyme exhibits higher activity in blood cells (hemocytes) from a predominantly resistant strain of B. glabrata ...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2006.12.005

    authors： Bender RC,Goodall CP,Blouin MS,Bayne CJ

    更新日期：2007-01-01 00:00:00

  • Identification and functional characterization of Dicer2 and five single VWC domain proteins of Litopenaeus vannamei.

    abstract：:Dicer (Dcr) is the key protein of the RNA interference (RNAi) pathway. To investigate the role of the RNAi pathway in shrimp anti-viral immunity, Litopenaeus vannamei Dcr2 (designated as LvDcr2) was identified and characterized. The full-length cDNA of LvDcr2 was 5513bp long, with an open reading frame encoding a puta...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2011.01.010

    authors： Chen YH,Jia XT,Zhao L,Li CZ,Zhang S,Chen YG,Weng SP,He JG

    更新日期：2011-06-01 00:00:00

  • Invertebrate immune diversity.

    abstract：:The arms race between hosts and pathogens (and other non-self) drives the molecular diversification of immune response genes in the host. Over long periods of evolutionary time, many different defense strategies have been employed by a wide variety of invertebrates. We review here penaeidins and crustins in crustacean...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2010.12.009

    authors： Ghosh J,Lun CM,Majeske AJ,Sacchi S,Schrankel CS,Smith LC

    更新日期：2011-09-01 00:00:00

  • Lectins and lectin-like molecules in lower plants. II. Freshwater algae.

    abstract：:Freshwater chlamydomonad algae possess flagella surface isoagglutinins of a glycoprotein nature which are involved in gamete recognition and consequent cell fusion. Alternatively, such molecules may have a receptor role in certain Chlamydomonas species. In some freshwater volvocaines, lectin-like substances act as ind...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/0145-305x(85)90002-3

    authors： Ingram GA

    更新日期：1985-07-01 00:00:00

  • In situ lymphocyte apoptosis in larval Xenopus laevis, the South African clawed toad.

    abstract：:During Anuran metamorphosis larval structures regress, adult structures form anew and impaired T cell immune functions are noted, as are alterations in endogenous glucocorticoid titers. In situ histological data, after staining for DNA fragmentation, reveal patterns of lymphocyte suicide in the thymus and spleen of no...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(97)00057-8

    authors： Grant P,Clothier RH,Johnson RO,Ruben LN

    更新日期：1998-07-01 00:00:00

  • Serum CRP-like protein profile in common carp Cyprinus carpio challenged with Aeromonas hydrophila and Escherichia coli lipopolysaccharide.

    abstract：:The potential of C-reactive protein (CRP)-like proteins to be used as a biomarker of health status in cultured carp obtained from various European fish lines has been assessed. Varying CRP-like protein levels in the serum of carp were monitored using an indirect competitive enzyme-linked immunosorbent assay. CRP-like ...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2008.04.004

    authors： MacCarthy EM,Burns I,Irnazarow I,Polwart A,Greenhough TJ,Shrive AK,Hoole D

    更新日期：2008-01-01 00:00:00

  • Ontogeny of the thymus in a teleost fish, Cyprinus carpio L.: developing thymocytes in the epithelial microenvironment.

    abstract：:A monoclonal antibody, WCL9, specific for membrane molecules of a thymocyte subpopulation was used to detect these cells in situ during the ontogeny of thymus. Cryo-sections revealed WCL9+ cells in the rudiment of the thymus (day 4 post fertilization); thereafter, the positive cells were observed exclusively in the co...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(98)00053-6

    authors： Romano N,Taverne-Thiele AJ,Fanelli M,Baldassini MR,Abelli L,Mastrolia L,Van Muiswinkel WB,Rombout JH

    更新日期：1999-03-01 00:00:00

  • A novel lipopolysaccharide-binding hemagglutinin isolated from hemocytes of the solitary ascidian, Halocynthia roretzi: it can agglutinate bacteria.

    abstract：:A hemagglutinin was isolated from hemocytes of the ascidian, Halocynthia roretzi, by a procedure including extraction and ion-exchange chromatography on CM-cellulose. The molecular weight of the hemagglutinin was estimated to be 120,000 by gel filtration. It was resistant to acid treatment but sensitive to alkali or h...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(91)90042-w

    authors： Azumi K,Ozeki S,Yokosawa H,Ishii S

    更新日期：1991-01-01 00:00:00

  • The occurrence of three D-J-C clusters within the dromedary TRB locus highlights a shared evolution in Tylopoda, Ruminantia and Suina.

    abstract：:The αβ T cells are important components of the adaptive immune system and can recognize a vast array of peptides presented by MHC molecules. The ability of these T cells to recognize the complex depends on the diversity of the αβ TR, which is generated by a recombination of specific Variable, Diversity and Joining gen...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2017.05.021

    authors： Antonacci R,Bellini M,Pala A,Mineccia M,Hassanane MS,Ciccarese S,Massari S

    更新日期：2017-11-01 00:00:00

  • Phylogeny, genomic organization and expression of lambda and kappa immunoglobulin light chain genes in a reptile, Anolis carolinensis.

    abstract：:The reptiles are the last major taxon of jawed vertebrates in which immunoglobulin light chain isotypes have not been well characterized. Using the recently released genome sequencing data, we show in this study that the reptile Anolis carolinensis expresses both lambda and kappa light chain genes. The genomic organiz...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2009.12.019

    authors： Wu Q,Wei Z,Yang Z,Wang T,Ren L,Hu X,Meng Q,Guo Y,Zhu Q,Robert J,Hammarström L,Li N,Zhao Y

    更新日期：2010-05-01 00:00:00

  • Host defense peptides in skin secretions of the Oregon spotted frog Rana pretiosa: implications for species resistance to chytridiomycosis.

    abstract：:Population declines due to chytridiomycosis among frogs belonging to the Amerana (Rana boylii) species group from western North America have been particularly severe. Norepinephrine-stimulated skin secretions from the Oregon spotted frog Rana pretiosa Baird and Girard, 1853 were collected from individuals that had bee...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2011.01.017

    authors： Conlon JM,Mechkarska M,Ahmed E,Coquet L,Jouenne T,Leprince J,Vaudry H,Hayes MP,Padgett-Flohr G

    更新日期：2011-06-01 00:00:00

  • In vitro interaction of Perkinsus marinus merozoites with eastern and Pacific oyster hemocytes.

    abstract：:This study compared hemocyte responses of eastern and Pacific oysters to Perkinsus marinus, in vitro. Except for the percentage of hemocytes associated with P. marinus there was little or no significant difference between eastern and Pacific oysters with regard to their hemocytic response to P. marinus. In phagocytosi...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(95)00017-n

    authors： La Peyre JF,Chu FL,Vogelbein WK

    更新日期：1995-07-01 00:00:00

  • Vaccination with multimeric recombinant VP28 induces high protection against white spot syndrome virus in shrimp.

    abstract：:To improve the efficacy of WSSV protection, multimeric (tetrameric) recombinant VP28 (4XrVP28) was produced and tested in comparison with those of monomeric VP28 (1XrVP28). In vitro binding of either 1XrVP28 or 4XrVP28 to shrimp hemocyte surface was evident as early as 10 min after protein inoculation. Similar results...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2017.05.016

    authors： Taengchaiyaphum S,Nakayama H,Srisala J,Khiev R,Aldama-Cano DJ,Thitamadee S,Sritunyalucksana K

    更新日期：2017-11-01 00:00:00

  • Granulocytes of the red claw crayfish Cherax quadricarinatus can endocytose beads, E. coli and WSSV, but in different ways.

    abstract：:The hemocytes of the red claw crayfish Cherax quadricarinatus are classified by morphologic observation into the following types: hyalinocytes (H), semi-granulocytes (SG) and granulocytes (G). Density gradient centrifugation with Percoll was developed to separate these three subpopulations of hemocytes. Beads, Escheri...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2014.04.006

    authors： Duan H,Jin S,Zhang Y,Li F,Xiang J

    更新日期：2014-10-01 00:00:00

  • Secretory immunity induced in catfish, Ictalurus punctatus, following bath immunization.

    abstract：:Individual adult channel catfish were immunized by immersion in an antigen bath containing dinitrophenylated-horse serum albumin. Anti-DNP hemagglutination titers of serum and cutaneous mucus were determined following both primary and secondary bath immunization. The results showed that five of the six fish had a cuta...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(87)90060-7

    authors： Lobb CJ

    更新日期：1987-10-01 00:00:00

  • Two prophenoloxidases are important for the survival of Vibrio harveyi challenged shrimp Penaeus monodon.

    abstract：:Phenoloxidase (PO) plays an important role in arthropod melanization. Previously, a prophenoloxidase (PmproPO1) gene was cloned and characterized from the hemocytes of the black tiger shrimp, Penaeus monodon. In the present study, we report a novel proPO gene (PmproPO2) belonging to the proPO family identified from th...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2008.09.003

    authors： Amparyup P,Charoensapsri W,Tassanakajon A

    更新日期：2009-02-01 00:00:00

  • Development of B cells in the gut-associated lymphoid tissue of mid-gestational fetal lambs.

    abstract：:Intestinal mucosal immune system development was investigated in fetal lambs from 61 to 110 days (term, 150 days). Fetal small intestine was examined at 400 mm intervals for the presence of IgM(+) cells. The first phase of B cell development was characterised by increase in B cell density throughout the jejunum from 6...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(02)00139-8

    authors： Alitheen N,McClure S,McCullagh P

    更新日期：2003-06-01 00:00:00

  • Phenotypic and functional characterization of earthworm coelomocyte subsets: Linking light scatter-based cell typing and imaging of the sorted populations.

    abstract：:Flow cytometry is a common approach to study invertebrate immune cells including earthworm coelomocytes. However, the link between light-scatter- and microscopy-based phenotyping remains obscured. Here we show, by means of light scatter-based cell sorting, both subpopulations (amoebocytes and eleocytes) can be physica...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2016.06.017

    authors： Engelmann P,Hayashi Y,Bodó K,Ernszt D,Somogyi I,Steib A,Orbán J,Pollák E,Nyitrai M,Németh P,Molnár L

    更新日期：2016-12-01 00:00:00

  • Trypanosoma cruzi is lysed by coelomic cytolytic factor-1, an invertebrate analogue of tumor necrosis factor, and induces phenoloxidase activity in the coelomic fluid of Eisenia foetida foetida.

    abstract：:A cytolytic protein named Coelomic Cytolytic Factor-1 (CCF-1) was isolated from the coelomic fluid of the earthworm Eisenia foetida foetida. Despite the absence of any gene homology, CCF-1 showed functional analogy with the mammalian cytokine tumour necrosis factor (TNF), particularly based on similar lectin-like acti...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(01)00048-9

    authors： Olivares Fontt E,Beschin A,Van Dijck E,Vercruysse V,Bilej M,Lucas R,De Baetselier P,Vray B

    更新日期：2002-01-01 00:00:00

  • Regulation of cnidarian-dinoflagellate mutualisms: Evidence that activation of a host TGFβ innate immune pathway promotes tolerance of the symbiont.

    abstract：:Animals must manage interactions with beneficial as well as detrimental microbes. Immunity therefore includes strategies for both resistance to and tolerance of microbial invaders. Transforming growth factor beta (TGFβ) cytokines have many functions in animals including a tolerance-promoting (tolerogenic) role in immu...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2012.08.008

    authors： Detournay O,Schnitzler CE,Poole A,Weis VM

    更新日期：2012-12-01 00:00:00

  • RNAi and antiviral defense in Drosophila: setting up a systemic immune response.

    abstract：:RNA interference (RNAi) controls gene expression in eukaryotic cells and thus, cellular homeostasis. In addition, in plants, nematodes and arthropods it is a central antiviral effector mechanism. Antiviral RNAi has been well described as a cell autonomous response, which is triggered by double-stranded RNA (dsRNA) mol...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2013.05.004

    authors： Karlikow M,Goic B,Saleh MC

    更新日期：2014-01-01 00:00:00

  • WITHDRAWN: Development of an RT-PCR-RFLP assay for the detection and differentiation of wild-type and vaccine strains of classical swine fever virus.

    abstract：:This article has been withdrawn at the request of the author(s). The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2012.05.002

    authors： Hu J,Shan H,Wang S,Yang P,Wang Y,Sun H,Huang J,Yang R,Zhang C,Qin X

    更新日期：2012-05-15 00:00:00

  • Characterization of serum immunoglobulins in a chondrostean fish, Acipenser baeri.

    abstract：:The euglobulin fraction of sturgeon (Acipenser baeri) serum was analyzed using electrophoretic and immunoblotting techniques. The major protein of this fraction is an IgM-like molecule composed of equimolar 70-kDa glycosylated H chains and 26-30 kDa L chains. In the absence of a reducing agent, the L and H polypeptide...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(05)80007-2

    authors： Partula S,Charlemagne J

    更新日期：1993-11-01 00:00:00

  • Binding of porcine ficolin-alpha to lipopolysaccharides from Gram-negative bacteria and lipoteichoic acids from Gram-positive bacteria.

    abstract：:Protein(s) reactive with N-acetyl-D-glucosamine (GlcNAc) was isolated from porcine nonimmune serum. The molecular weight of the purified protein was found to be mainly 40 kDa on sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing conditions. The N-terminal 10 amino acid sequence of the purified pr...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2005.04.002

    authors： Nahid AM,Sugii S

    更新日期：2006-01-01 00:00:00

  • In vitro production of hydrogen peroxide by the amoebocytes of the scallop, Patinopecten yessoensis (Jay).

    abstract：:In vitro production of hydrogen peroxide (H2O2) by the amoebocytes of the scallop, Patinopecten yessoensis, was studied. The authors first confirmed the availability of the direct quantitative method using homovanillic acid, and found that both resting and stimulated amoebocytes produced H2O2. However, the latter show...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(85)90004-7

    authors： Nakamura M,Mori K,Inooka S,Nomura T

    更新日期：1985-07-01 00:00:00

  • The discrepancy function of NLRC5 isoforms in antiviral and antibacterial immune responses.

    abstract：:NOD-like receptors (NLRs) are a family of intracellular pattern recognition receptors (PRRs) that play critical roles in innate immunity against pathogens infection. NLRC5, the largest member of NLR family, has been characterized as a regulator of innate immunity and MHC class I expression. Alternative splicing of NLR...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2018.02.013

    authors： Cao L,Wu XM,Hu YW,Xue NN,Nie P,Chang MX

    更新日期：2018-07-01 00:00:00

  • Molecular cloning, expression and functional analysis of interleukin-8 (IL-8) in South African clawed frog (Xenopus laevis).

    abstract：:In this study, an IL-8 homologue has been cloned and identified from South African clawed frog Xenopus laevis (designated XlIL-8). The open reading frame (ORF) of XlIL-8 consists of 312 bases encoding a protein of 103 amino acids. The chemokine CXC domain, which contained Glu-Leu-Arg (ELR) motif and four cysteine resi...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2011.04.005

    authors： Cui X,Han Y,Pan Y,Xu X,Ren W,Zhang S

    更新日期：2011-11-01 00:00:00

  • Recent advances on the immunobiology of Bithynia spp. hosts of Opisthorchis viverrini.

    abstract：:This article reviews the past and present scientific reports regarding Bithynia spp. focusing on the biology, ecology and life cycle of Bithynia snails and their responses to Opisthorchis viverrini infection. Moreover, new data regarding comparative molecular genomics and proteomic approaches have recently revealed no...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2019.103460

    authors： Suwannatrai K,Suwannatrai AT,Loukas A,Sotillo J

    更新日期：2020-01-01 00:00:00