Abstract:
:The ileal Peyer's patch (IPP) of young sheep is a site of diversification of the primary antibody repertoire and where involution takes place at young age. Tissue samples from the ileum were collected in 134 animals aged from 1 month to 6 years, and IPP follicle phenotypes were characterised. We describe a new type of ileal lymphoid follicles that became relatively more frequent during involution, and had numerous intrafollicular T-cells and BAQ44A+ B-cells and large interfollicular T-cell areas. As opposed to classical IPP follicles in which the BAQ44A+ cells were confined to the narrow follicle-neck region, the novel atypical ileal lymphoid follicle had these cells distributed throughout the follicle. The relative distribution of cell types in the typical IPP follicle remained fairly constant during involution. Many animals older than 9 months (64/92) still had had typical IPP follicles and even sheep 4 years and older (5/9) had IPP-type follicles.
journal_name
Dev Comp Immunoljournal_title
Developmental and comparative immunologyauthors
Lie KI,Aleksandersen M,Landsverk Tdoi
10.1016/j.dci.2004.10.009keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
539-53issue
6eissn
0145-305Xissn
1879-0089pii
S0145-305X(04)00178-8journal_volume
29pub_type
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