Abstract：
:Double-stranded RNA (dsRNA) is a common virus-associated molecular pattern and a potent inducer of antiviral responses in many organisms. While it is clear that the specific RNA interference (RNAi) response, a phenomenon triggered by dsRNA, serves antiviral functions in invertebrates, innate (non-specific) antiviral immune reactions induced by dsRNA (e.g. the Interferon response) have long been thought to be restricted to vertebrates. Recent work in an underappreciated experimental model, the penaeid shrimp, is challenging these traditional distinctions, by demonstrating the existence of both innate (non sequence-specific) and RNAi-related (sequence-specific) antiviral phenomena in crustacea. Here we discuss the evidence for this bivalent role of dsRNA in the initiation of antiviral responses in shrimp, and present new data that suggest that the antiviral functions of the shrimp RNAi machinery have imposed selective pressures on an evolving viral pathogen. These findings open the door for the discovery of novel mechanisms of innate immunity, and provide a basis for the future development of strategies to control viral diseases in the commercially important penaeid shrimp.
journal_name
Dev Comp Immunoljournal_title
Developmental and comparative immunologyauthors
Robalino J,Bartlett TC,Chapman RW,Gross PS,Browdy CL,Warr GWdoi
10.1016/j.dci.2006.08.011subject
Has Abstractpub_date
2007-01-01 00:00:00pages
539-47issue
6eissn
0145-305Xissn
1879-0089pii
S0145-305X(06)00169-8journal_volume
31pub_type
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journal_title：Developmental and comparative immunology
pub_type： 杂志文章
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journal_title：Developmental and comparative immunology
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journal_title：Developmental and comparative immunology
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