当前位置： SCI文献检索 > DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY期刊下所有文献 > Identification of a target cell antigen recognized by nonspecific cytotoxic cells using an anti-idiotype monoclonal antibody.

Identification of a target cell antigen recognized by nonspecific cytotoxic cells using an anti-idiotype monoclonal antibody.

Abstract：

:Nonspecific cytotoxic cells (NCC) are the teleost equivalent of mammalian natural killer (NK) cells. In the present study an anti-idiotypic monoclonal antibody (mAb 7D12) was generated against idiotopes on an mAb (mAb 6D3.2) that recognizes a putative receptor on NCC. The idiotypic specificity of mAb 7D12 was determined in competition assays by incubating biotinylated mAb 7D12 with mAb 6D3.2 hybridoma cells following preincubation with combinations of biotinylated 7D12 with either nonbiotinylated homologous or heterologous mAb. The ligand recognized by mAb 7D12 (determined by flow cytometry) was found on cells from the anterior kidney, spleen, thymus, PBL, liver, and brain. NCC lysis of IM-9 targets was inhibited 76% following preincubation of the target cells with different concentrations of mAb 7D12. The involvement of the ligand recognized by mAb 7D12 in the NCC lytic cycle was determined by showing that this mAb produced 50% inhibition of NCC conjugate formation with NC-37 target cells. Biochemical analysis using SDS-PAGE and Western blotting revealed that mAb 7D12 recognized 54 and 65 M(r) proteins in IM-9 target cell lysates. These studies demonstrated that an idiotope on a NCC specific anti-receptor mAb was an "internal image" of a target cell ligand. The anti-id mAb generated against this image (idiotope) inhibited NCC cytotoxicity and thus was equivalent to an NCC receptor that binds to a target cell ligand involved in NCC recognition.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Lester JP 3rd,Evans DL,Leary JH 3rd,Fowler SC,Jaso-Friedmann L

doi

10.1016/0145-305x(94)90014-0

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

219-29

issue

3

eissn

0145-305X

issn

1879-0089

pii

0145-305X(94)90014-0

journal_volume

18

pub_type

杂志文章

相关文献

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY文献大全
  • Retrospection to discovery of bursal function and recognition of avian dendritic cells; past and present.

    abstract：:In 1954 the discovery of bursal function was one of the major contributions to the formation of the T and B cell concept of immunology. In 1978 the avian dendritic cells; bursal secretory dendritic cell (BSDC) and follicular dendritic cell (FDC) in the cecal tonsil were recognized. In 1982 the interdigitating dendriti...

    journal_title：Developmental and comparative immunology

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.dci.2013.03.007

    authors： Oláh I,Nagy N

    更新日期：2013-11-01 00:00:00

  • Molecular characterization and expression analysis of four isotypes of immunoglobulin light chain genes in orange-spotted grouper, Epinephelus coioides.

    abstract：:To date, many immunoglobulin (Ig) genes have been identified in diverse teleost species, but the contributions of different types of light chain (IgL) to the immune response remain unclear. Screening of a stimulated kidney cDNA library from orange-spotted grouper (Osg, Epinephelus coioides) resulted in the identificat...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2012.11.003

    authors： Wu MS,Cheng CA,Lin CH,Lee CY,Tseng SJ,Tzeng CS,Chang CY

    更新日期：2013-03-01 00:00:00

  • Five subfamilies of β-defensin genes are present in salmonids: Evolutionary insights and expression analysis in Atlantic salmon Salmo salar.

    abstract：:β-defensins (BD) are the largest family of vertebrate defensins with potent antimicrobial, chemotactic and immune-regulatory activities. Four BD genes (BD1-4) have been cloned previously in rainbow trout but none have been reported in other salmonids. In this study seven BD genes (BD1a-b, 2-4, 5a-b) are characterised ...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2019.103560

    authors： Harte A,Tian G,Xu Q,Secombes CJ,Wang T

    更新日期：2020-03-01 00:00:00

  • Antisense approaches for elucidating ranavirus gene function in an infected fish cell line.

    abstract：:Viral virulence/immune evasion strategies and host anti-viral responses represent different sides of the continuing struggle between virus and host survival. To identify virus-encoding molecules whose function is to subvert or blunt host immune responses, we have adapted anti-sense approaches to knock down the express...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2010.12.002

    authors： Whitley DS,Sample RC,Sinning AR,Henegar J,Chinchar VG

    更新日期：2011-09-01 00:00:00

  • B-cell development in bovine fetuses proceeds via a pre-B like cell in bone marrow and lymph nodes.

    abstract：:The production of B cells and the primary antibody repertoire in mammalian species other than rodents or man appears to depend on gut-associated lymphoid tissue. Bovine B cells are generated in ileal Peyer's patch from late gestational to juvenile age. However, little is known about where and when the bona fide B lymp...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2010.03.012

    authors： Ekman A,Pessa-Morikawa T,Liljavirta J,Niku M,Iivanainen A

    更新日期：2010-08-01 00:00:00

  • Immunopathogenesis of haemorrhagic enteritis virus (HEV) in turkeys.

    abstract：:Infection of turkeys with the haemorrhagic enteritis virus (HEV), a type II avian adenovirus, results in varying rates of morbidity and mortality. The disease is characterised by splenomegaly, intestinal haemorrhage, sudden death and immunosuppression. The mechanisms of HEV immunopathogenesis and immunosuppression are...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0145-305x(99)00075-0

    authors： Rautenschlein S,Sharma JM

    更新日期：2000-03-01 00:00:00

  • The diversity of C-type lectins in the genome of a basal metazoan, Nematostella vectensis.

    abstract：:C-type lectins (CTLs) are involved in cell-cell adhesion, recognition, and innate immunity in higher vertebrates, but little is known about CTLs in basal metazoans. The recent sequencing of the cnidarian Nematostella vectensis genome allowed us to explore the CTL-like gene family at the base of metazoan evolution. Six...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2009.01.008

    authors： Wood-Charlson EM,Weis VM

    更新日期：2009-08-01 00:00:00

  • Purification and binding properties of porcine plasma ficolin that binds Actinobacillus pleuropneumoniae.

    abstract：:Previous studies demonstrated that porcine plasma ficolin binds the important pig pathogen Actinobacillus pleuropneumoniae (APP) in an N-acetylglucosamine-dependent manner. In the present study, attempts to characterize the bacterial-binding properties of ficolin indicated ficolin is the major porcine plasma protein t...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(03)00057-0

    authors： Brooks AS,DeLay JP,Hayes MA

    更新日期：2003-10-01 00:00:00

  • microRNA-589-5p modulates the expression of hemocyanin as part of the anti-WSSV immune response in Litopenaeus vannamei.

    abstract：:The respiratory glycoprotein, hemocyanin (HMC) has multiple immune-related functions, including antiviral activity. In this study, in silico methods were used to predict seven miRNAs targeting Litopenaeus vannamei HMC (LvHMC), out of which miR-589-5p was selected for further investigation because of its role in immune...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2020.103642

    authors： Bao S,Zheng Z,Aweya JJ,Yao D,Li S,Sun C,Hong Y,Zhang Y

    更新日期：2020-06-01 00:00:00

  • Antimicrobial mechanisms of fish leukocytes.

    abstract：:Early activation and coordination of innate defenses are critical for effective responses against infiltrating pathogens. Rapid engagement of immune cells provides a critical first line of defense soon after pathogen infiltration. Activation leads to a well-orchestrated set of events that sees the induction and regula...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2011.03.009

    authors： Rieger AM,Barreda DR

    更新日期：2011-12-01 00:00:00

  • Duck lymphocytes. IV. Collective effects of mitogens.

    abstract：:Duck (Anas platyrhynchos) blood lymphocytes were cultured in the presence of phytohaemagglutinin (PHA), concanavalin A (Con A), pokeweed mitogen (PWM), lentil lectin (LL), Roman snail lectin (HP), wheat germ agglutinin (WGA), Bandeiraea simplicifolia seed lectin (BSS), peanut agglutinin (PNA), horseshoe crab lectin (H...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(91)90028-w

    authors： Higgins DA

    更新日期：1991-10-01 00:00:00

  • Ultrastructural analysis of leucocyte interaction with tumour targets in a teleost, Cyprinus carpio L.

    abstract：:The first step in natural killer activity, target cell binding, was investigated ultrastructurally in order to identify presumptive cytotoxic cells. After incubation of unfractioned peripheral blood cells of the carp, Cyprinus carpio L., with HeLa tumour cells as targets, regular conjugate forming was observed. Target...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(88)90055-9

    authors： Bielek E

    更新日期：1988-10-01 00:00:00

  • Effects of Trichobilharzia ocellata on hemocytes of Lymnaea stagnalis.

    abstract：:We analyzed the effects of infection with Trichobilharzia ocellata on hemocytes of its snail host, Lymnaea stagnalis, and correlated them with successive stages of parasite development. Circulating hemocytes were studied at 0, 2, 4, 6, and 8 weeks post exposure (p.e.) with respect to cell number, distribution of subpo...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(91)90001-f

    authors： Amen RI,Tijnagel JM,van der Knaap WP,Meuleman EA,de Lange-de Klerk ES,Sminia T

    更新日期：1991-04-01 00:00:00

  • Molecular cloning, characterization and function of a germinal center kinase MST4 gene from Litopenaeus vannamei in response to Vibrio alginolyticus challenge in TLR-TRAF6 signaling pathway.

    abstract：:The serine/threonine protein kinase MST4 plays multiple roles in the regulation of signaling pathways that govern cellular processes including mitosis, migration, homeostasis, polarity, proliferation, differentiation and apoptosis. Here we report the identification and characterization of the full-length sequence of L...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2017.03.026

    authors： Zhao CS,Huang D,Peng T,Huang MZ,Xie CY,Chen J,Kong JR,Xie RC,Liu Y,Wang WN

    更新日期：2017-08-01 00:00:00

  • Spry is downregulated by multiple viruses to elevate ERK signaling and ensure viral reproduction in silkworm.

    abstract：:Viral diseases of silkworm are mainly caused by Bombyx mori nucleopolyhedrovirus (BmNPV), B. mori cytoplasmic polyhedrosis virus (BmCPV) and B. mori bidensovirus (BmBDV). The virus alters host cellular pathways to facilitate its proliferation. It is still unclear whether the three silkworm viruses regulate a certain h...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2019.04.001

    authors： Guo H,Sun Q,Wang B,Wang Y,Xie E,Xia Q,Jiang L

    更新日期：2019-09-01 00:00:00

  • Invertebrate immune diversity.

    abstract：:The arms race between hosts and pathogens (and other non-self) drives the molecular diversification of immune response genes in the host. Over long periods of evolutionary time, many different defense strategies have been employed by a wide variety of invertebrates. We review here penaeidins and crustins in crustacean...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.dci.2010.12.009

    authors： Ghosh J,Lun CM,Majeske AJ,Sacchi S,Schrankel CS,Smith LC

    更新日期：2011-09-01 00:00:00

  • IL-12 and IL-18 induce interferon-γ production and de novo CD2 expression in porcine γδ T cells.

    abstract：:γδ T cells are highly abundant in the blood and spleen of pigs but little is known about their functional differentiation. In this study the potential of the type-1 polarizing cytokines IL-12 and IL-18 in combination with IL-2 and Concanavalin A (ConA) to stimulate porcine γδ T cells was investigated. Stimulation of p...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2014.07.007

    authors： Sedlak C,Patzl M,Saalmüller A,Gerner W

    更新日期：2014-11-01 00:00:00

  • Suppression of chemiluminescence of eastern oyster (Crassostrea virginica) hemocytes by the protozoan parasite Perkinsus marinus.

    abstract：:Experiments were conducted to determine the ability of the protistan parasite, Perkinsus marinus, to inhibit chemiluminescence of hemocytes from the eastern oyster, Crassostrea virginica. Luminol-enhanced chemiluminescence (CL) was used to measure the production of reactive oxygen intermediates (ROI) generated by oyst...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(94)00059-o

    authors： Volety AK,Chu FL

    更新日期：1995-03-01 00:00:00

  • Trypanosoma carassii hsp70 increases expression of inflammatory cytokines and chemokines in macrophages of the goldfish (Carassius auratus L.).

    abstract：:We report on the cloning and characterization of Trypanosoma carassii 70 KDa heat shock protein (hsp70). T. carassii hsp70 was secreted/excreted into culture medium in vitro and was recognized by sera from infected fish. Recombinant hsp70 (rhsp70) activated goldfish macrophages and stimulated the production of pro-inf...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2009.06.003

    authors： Oladiran A,Belosevic M

    更新日期：2009-10-01 00:00:00

  • The sensing pattern and antitoxic response of Crassostrea gigas against extracellular products of Vibrio splendidus.

    abstract：:Serious juvenile oyster disease induced by pathogenic Vibrio splendidus has resulted in tremendous economic loss, but the molecular mechanisms underlying this killing mechanism remain unclear. The resistance of adult oyster to V. splendidus or its virulence factors might provide a possible access to cognize the intera...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2019.103467

    authors： Wang W,Lv X,Liu Z,Song X,Yi Q,Wang L,Song L

    更新日期：2020-01-01 00:00:00

  • Comparative genomics analysis of five families of antimicrobial peptide-like genes in seven ant species.

    abstract：:Ants, as eusocial insects, live in dense groups with high connectivity, increasing the risk of pathogen spread and possibly driving the evolution of their antimicrobial immune system. Draft genomes of seven ant species provide a new source to undertake comparative study of their antimicrobial peptides (AMPs), key comp...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2012.05.003

    authors： Zhang Z,Zhu S

    更新日期：2012-10-01 00:00:00

  • Genomic organization and differential expression of channel catfish MHC class I genes.

    abstract：:Two clones, designated Icpu-UA/3 and Icpu-UA/26, were isolated from a genomic library prepared from a single homozygous gynogenetic channel catfish. Sequence analysis showed that each clone encoded a gene product containing features conserved among MHC class I molecules. The genomic organization of both clones indicat...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(01)00017-9

    authors： Antao AB,Wilson M,Wang J,Bengtén E,Miller NW,Clem LW,Chinchar VG

    更新日期：2001-09-01 00:00:00

  • Nuclear receptor E75 is a transcription suppressor of the Litopenaeus vannamei small subunit hemocyanin gene.

    abstract：:Hemocyanin is a respiratory protein that possesses multiple physiological and immunological functions in shrimp. However, the transcriptional regulation of the hemocyanin gene is still poorly understood. Here, the nuclear receptor E75 of Litopenaeus vannamei (LvE75) was identified as one of the transcriptional regulat...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2020.103662

    authors： Zhang Z,Yao D,Yang P,Zheng Z,Aweya JJ,Lun J,Ma H,Zhang Y

    更新日期：2020-06-01 00:00:00

  • A serpin from the parasitoid wasp Leptopilina boulardi targets the Drosophila phenoloxidase cascade.

    abstract：:The insect phenoloxidase (PO) cascade is known to be tightly regulated by serine proteases and serine protease inhibitors of the serpin family. As a key component of the insect immune system, it is also suspected to be inhibited by several endoparasitoid wasps, insects that develop inside other arthropods as hosts. Ho...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2008.11.013

    authors： Colinet D,Dubuffet A,Cazes D,Moreau S,Drezen JM,Poirié M

    更新日期：2009-05-01 00:00:00

  • Loss of CD28 expression on T lymphocytes: a marker of replicative senescence.

    abstract：:The CD28 molecule, a disulfide-linked homodimer expressed on peripheral T cells and thymocytes, mediates an essential costimulatory signal following engagement of the T cell receptor (TCR). Increased proportions of CD28- T cells have been observed during aging and in situations of chronic immune stimulation, but the o...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/s0145-305x(97)00027-x

    authors： Effros RB

    更新日期：1997-11-01 00:00:00

  • Thioredoxin peroxidase gene is involved in resistance to biocontrol fungus Nomuraea rileyi in Spodoptera litura: gene cloning, expression, localization and function.

    abstract：:Thioredoxin peroxidases (Tpxs) are a ubiquitous family of antioxidant enzymes that play important roles in protecting organisms against oxidative stress. Here, one Tpx was cloned from Spodoptera litura named as SlTpx. The full-length cDNA consists of 1165 bp with 588 bp open reading frame, encoding 195 amino acids. Th...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2013.11.012

    authors： Chen H,Yin Y,Feng E,Li Y,Xie X,Wang Z

    更新日期：2014-05-01 00:00:00

  • A class B scavenger receptor mediates antimicrobial peptide secretion and phagocytosis in Chinese mitten crab (Eriocheir sinensis).

    abstract：:Scavenger receptors (SRs) are pattern recognition receptors (PRRs) vital for innate immunity. As well as their importance in immune recognition, microbe phagocytosis, and the clearance of modified endogenous molecules, they also activate downstream immune responses as co-receptors. In the current study, we identified ...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2019.103496

    authors： Tang M,Li X,Yang L,Wang Q,Li W

    更新日期：2020-02-01 00:00:00

  • High doses of sodium ascorbate act as a prooxidant and protect gnotobiotic brine shrimp larvae (Artemia franciscana) against Vibrio harveyi infection coinciding with heat shock protein 70 activation.

    abstract：:Ascorbate is an essential nutrient commonly regarded as an antioxidant. In this study, using axenic brine shrimp and pathogenic strain Vibrio harveyi as the host-pathogen model, we confirmed that pretreatment of sodium ascorbate (NaAs), at an optimum concentration, was a prooxidant by generation of hydrogen peroxide, ...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2018.11.007

    authors： Han B,Kaur VI,Baruah K,Nguyen VD,Bossier P

    更新日期：2019-03-01 00:00:00

  • Temperature-mediated processes in teleost immunity: differential effects of in vitro and in vivo temperatures on mitogenic responses of channel catfish lymphocytes.

    abstract：:The in vitro mitogenic responses of channel catfish peripheral blood leucocytes to ConA and LPS were differentially affected by both in vitro and in vivo temperatures. The magnitude of the response to LPS was relatively independent of both in vitro culture temperature and in vivo acclimation temperature. The magnitude...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/0145-305x(84)90038-7

    authors： Clem LW,Faulmann E,Miller NW,Ellsaesser C,Lobb CJ,Cuchens MA

    更新日期：1984-04-01 00:00:00

  • Cloning and characterising an unusual perforin from chicken (Gallus gallus).

    abstract：:In mammals the 67 kDa pore-forming protein perforin is essential to the granule exocytosis pathway used by cytotoxic lymphocytes to eliminate virally infected and malignant cells. There is indirect evidence that this pathway exists in lower vertebrates such as teleost fish and birds, although in genome databases for t...

    journal_title：Developmental and comparative immunology

    pub_type： 杂志文章

    doi：10.1016/j.dci.2013.05.003

    authors： D'Angelo ME,Arjomand A,Trapani JA,Bird PI

    更新日期：2013-10-01 00:00:00