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Nuclear receptor E75 is a transcription suppressor of the Litopenaeus vannamei small subunit hemocyanin gene.

Abstract：

:Hemocyanin is a respiratory protein that possesses multiple physiological and immunological functions in shrimp. However, the transcriptional regulation of the hemocyanin gene is still poorly understood. Here, the nuclear receptor E75 of Litopenaeus vannamei (LvE75) was identified as one of the transcriptional regulators that modulates the transcription of the small molecular weight hemocyanin gene of L. vannamei (LvHMCs) by inhibiting its core promoter activity in a Dual-luciferase assay. In silico analysis revealed that the core promoter (designated HsP3), which is located at +1517/+1849 bp of LvHMCs contained a putative E75 binding motif ("ACGGAAT", spanning +1812/+1818 bp). Further, LvE75 was shown to inhibit the core promoter activity by direct binding. Importantly, in vivo silencing of LvE75 resulted in a significant upregulation in the mRNA and protein expression of LvHMCs gene. Taken together, our present results provide direct evidence that LvE75 is a transcriptional suppressor of the LvHMCs gene expression.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Zhang Z,Yao D,Yang P,Zheng Z,Aweya JJ,Lun J,Ma H,Zhang Y

doi

10.1016/j.dci.2020.103662

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

103662

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(20)30038-0

journal_volume

107

pub_type

杂志文章

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