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A serpin from the parasitoid wasp Leptopilina boulardi targets the Drosophila phenoloxidase cascade.

Abstract：

:The insect phenoloxidase (PO) cascade is known to be tightly regulated by serine proteases and serine protease inhibitors of the serpin family. As a key component of the insect immune system, it is also suspected to be inhibited by several endoparasitoid wasps, insects that develop inside other arthropods as hosts. However, the underlying mechanisms of this inhibition are largely undescribed. Here, we report the characterization of a gene encoding a serpin, LbSPNy, highly expressed in the venom of the wasp Leptopilina boulardi (IS(y) type), and we show that either the venom or the recombinant LbSPNy inhibit the PO cascade in the hemolymph of Drosophila yakuba host larva. Altogether, our results identify the first serpin used as a virulence factor by a parasitoid wasp and show that it disrupts the activation pathway of the PO in the Drosophila host.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Colinet D,Dubuffet A,Cazes D,Moreau S,Drezen JM,Poirié M

doi

10.1016/j.dci.2008.11.013

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

681-9

issue

5

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(08)00275-9

journal_volume

33

pub_type

杂志文章

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