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The Drosophila IMD pathway in the activation of the humoral immune response.

Abstract：

:The IMD pathway signaling plays a pivotal role in the Drosophila defense against bacteria. During the last two decades, significant progress has been made in identifying the components and deciphering the molecular mechanisms underlying this pathway, including the means of bacterial sensing and signal transduction. While these findings have contributed to the understanding of the immune signaling in insects, they have also provided new insights in studying the mammalian NF-κB signaling pathways. Here, we summarize the current view of the IMD pathway focusing on how it regulates the humoral immune response of Drosophila.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Kleino A,Silverman N

doi

10.1016/j.dci.2013.05.014

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

25-35

issue

1

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(13)00141-9

journal_volume

42

pub_type

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