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Evolution of thymus organogenesis.

Abstract：

:The thymus is the primary organ for functional T lymphocyte development in jawed vertebrates. A new study in the jawless fish, lampreys, indicates the existence of a primitive thymus in these surviving representatives of the most ancient vertebrates, providing strong evidence of co-evolution of T cells and thymus. This review summarizes the wealth of data that have been generated towards understanding the evolution of the thymus in the vertebrates. Progress in identifying genetic networks and cellular mechanisms that control thymus organogenesis in mammals and their evolution in lower species may inspire the development of new strategies for medical interventions targeting faulty thymus functions.

journal_name

Dev Comp Immunol

journal_title

Developmental and comparative immunology

authors

Ge Q,Zhao Y

doi

10.1016/j.dci.2012.01.002

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

85-90

issue

1-2

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(12)00003-1

journal_volume

39

pub_type

杂志文章,评审

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