Age-related thymic atrophy in the guinea pig.

Abstract:

:We have characterized age-related thymic atrophy in the guinea pig, including identification of antibodies that allow immunohistochemical assessment of thymopoiesis. Age-related thymic atrophy in guinea pigs more closely resembles what occurs in humans histologically and in thymus weight, cellularity, and percent functional area than do other rodent models. The guinea pig model is thus particularly well-suited to study the role of the thymic perivascular space in age-related thymic atrophy. We next tested the hypothesis that dietary supplementation with Vitamin C could prevent or delay age-related thymic atrophy. Thymus histology, weight, cellularity, and percent functional area did not differ at 12 months between groups that received 3, 30, or 150 mg Vitamin C daily from 4 months of age. Thus long-term supplementation with up to 130 mg/kg/day Vitamin C is insufficient to influence the time course and extent of age-related thymic atrophy in guinea pigs.

journal_name

Dev Comp Immunol

authors

Hale LP,Clark AG,Li J,Greer PK,Byers Kraus V

doi

10.1016/s0145-305x(00)00071-9

keywords:

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

509-18

issue

5-6

eissn

0145-305X

issn

1879-0089

pii

S0145-305X(00)00071-9

journal_volume

25

pub_type

杂志文章
  • Manduca sexta lipopolysaccharide-specific immulectin-2 protects larvae from bacterial infection.

    abstract::We previously reported the isolation of a lipopolysaccharide (LPS)-specific immulectin-2 from the tobacco hornworm, Manduca sexta [J. Biol. Chem. 275 (2000) 37373]. Immulectin-2 is a C-type lectin that is present at a constitutively low level in hemolymph of naive larvae, and its synthesis is induced after injection o...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/s0145-305x(02)00099-x

    authors: Yu XQ,Kanost MR

    更新日期:2003-03-01 00:00:00

  • Gene expression study in Bathymodiolus azoricus populations from three North Atlantic hydrothermal vent sites.

    abstract::The deep-sea hydrothermal vents are known as harsh environments, abundant in animal diversity surrounded by fluids with specific physiological and chemical composition. Bathymodiolus azoricus mussels are endemic species dwelling at hydrothermal vent sites and at distinct depth ranges. Mussels from Menez Gwen (MG), Luc...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/j.dci.2019.05.001

    authors: Martins E,Bettencourt R

    更新日期:2019-10-01 00:00:00

  • Effect of experimental microbial challenge on the expression of defense molecules in Eisenia foetida earthworm.

    abstract::Earthworms are able to protect themselves against invading pathogens due to efficient innate defense mechanisms. Currently, two types of antimicrobial factors including lysozyme-like molecule and factors with hemolytic activity, as well as a pattern recognition protein named coelomic cytolytic factor (CCF) have been i...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/j.dci.2004.01.001

    authors: Köhlerová P,Beschin A,Silerová M,De Baetselier P,Bilej M

    更新日期:2004-06-01 00:00:00

  • Cloning of Litopenaeus vannamei CD63 and it's role in white spot syndrome virus infection.

    abstract::White Spot Syndrome Virus (WSSV) is currently the most serious shrimp pathogen, which has brought huge losses to shrimp industry worldwide. CD63 of shrimp belongs to the tetraspanin superfamily, which plays an important role in signal transduction and immune process. In this paper, CD63 cDNA sequence of Litopenaeus va...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/j.dci.2016.03.004

    authors: Guan GK,Liu QH,Li C,Huang J

    更新日期:2016-07-01 00:00:00

  • Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick.

    abstract::The intestinal immune system in Gallus species must rapidly adapt to the omnivorous onset of an adult diet and to colonization by commensal bacteria. Yet, acquired immune functions in Gallus digestive tract fully develop only towards the end of the first week post-hatch. This raises the question of immune protection i...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/j.dci.2005.12.002

    authors: Bar-Shira E,Friedman A

    更新日期:2006-01-01 00:00:00

  • Serum CRP-like protein profile in common carp Cyprinus carpio challenged with Aeromonas hydrophila and Escherichia coli lipopolysaccharide.

    abstract::The potential of C-reactive protein (CRP)-like proteins to be used as a biomarker of health status in cultured carp obtained from various European fish lines has been assessed. Varying CRP-like protein levels in the serum of carp were monitored using an indirect competitive enzyme-linked immunosorbent assay. CRP-like ...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/j.dci.2008.04.004

    authors: MacCarthy EM,Burns I,Irnazarow I,Polwart A,Greenhough TJ,Shrive AK,Hoole D

    更新日期:2008-01-01 00:00:00

  • Cloning of the IL-1β3 gene and IL-1β4 pseudogene in salmonids uncovers a second type of IL-1β gene in teleost fish.

    abstract::To date two closely related interleukin-1β genes (IL-1β1 and IL-β2) have been found in salmonids. The cloning of trout and salmon IL-1β3, and a salmon IL-1β4 pseudogene reveals that two types of IL-1β genes exist in teleost species. Type I teleost IL-1β genes, including salmonid IL-1β3, share a similar 6 coding exon s...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/j.dci.2012.07.010

    authors: Husain M,Bird S,van Zwieten R,Secombes CJ,Wang T

    更新日期:2012-11-01 00:00:00

  • Immunological regulation by a β-adrenergic-like octopamine receptor gene in crowded larvae of the oriental Armyworm, Mythmina separata.

    abstract::Recent reports demonstrate that octopamine plays an important immunological role in crowded larvae of the Oriental Armyworm, Mythmina separata. We identified an octopamine receptor, the β-adrenergic-like gene (designated MsOctβ2R), with a 1191 bp open reading frame that encodes 396 amino acids and contains seven conse...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/j.dci.2020.103802

    authors: Kong H,Yuan L,Dong C,Zheng M,Jing W,Tian Z,Hou Q,Cheng Y,Zhang L,Jiang X,Luo L

    更新日期:2020-12-01 00:00:00

  • Black carp RIPK1 negatively regulates MAVS-mediated antiviral signaling during the innate immune activation.

    abstract::Receptor-interacting serine/threonine protein kinase 1 (RIPK1) is an important regulator of necroptosis and involved in innate immune response in human and mammal; however, its function in teleost fish mains largely unknown. In this paper, the RIPK1 homologue of black carp (Mylopharyngodon piceus) has been cloned and ...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/j.dci.2020.103726

    authors: Xie X,Cao Y,Dai Y,Chen Z,Wei J,Tan Y,Wu H,Feng H

    更新日期:2020-08-01 00:00:00

  • Transcriptional dynamics of immune, growth and stress related genes in skeletal muscle of the fine flounder (Paralichthys adpersus) during different nutritional statuses.

    abstract::The effects of stress on immune activity and growth in early vertebrates have not been studied in detail. The present study used fine flounder (Paralichthys adspersus) skeletal muscle as a model to evaluate molecules involved in the stress response, including the glucocorticoid receptors, foxo1/3, and the target genes...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/j.dci.2015.06.007

    authors: Valenzuela CA,Escobar D,Perez L,Zuloaga R,Estrada JM,Mercado L,Valdés JA,Molina A

    更新日期:2015-11-01 00:00:00

  • Thrombopoietin (TPO) induces thrombocytic colony formation of kidney cells synergistically with kit ligand A and a non-secretory TPO variant exists in common carp.

    abstract::The development of mammalian megakaryocytes and platelets is regulated by numerous cytokine signals, primarily through the thrombopoietin (TPO)/c-MPL axis. Although non-mammalian vertebrates are known to possess nucleated thrombocytes functionally equivalent to mammalian platelets, the dynamics of the thrombocyte deve...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/j.dci.2018.03.005

    authors: Katakura F,Sugie Y,Hayashi K,Nishiya K,Miyamae J,Okano M,Nakanishi T,Moritomo T

    更新日期:2018-07-01 00:00:00

  • Genetics of anti-parasite resistance in invertebrates.

    abstract::This review summarizes and compares available data on genetic and molecular aspects of resistance in four well-described invertebrate host-parasite systems: snail-schistosome, mosquito-malaria, mosquito-filarial worm, and Drosophila-wasp associations. It underlies that the major components of the immune reaction, such...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.dci.2004.05.004

    authors: Carton Y,Nappi AJ,Poirie M

    更新日期:2005-01-01 00:00:00

  • Recombinant chicken IL-6 does not activate heterophils isolated from day-old chickens in vitro.

    abstract::Pro-inflammatory cytokines are produced as part of innate immunity. Increased resistance to extraintestinal Salmonella enteritidis (SE) has been associated with an increase in heterophil pro-inflammatory cytokine gene expression. Invasion of chicken epithelial cells by SE induces an 8- to 10-fold increase in interleuk...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/j.dci.2004.08.002

    authors: Ferro PJ,Swaggerty CL,He H,Rothwell L,Kaiser P,Kogut MH

    更新日期:2005-01-01 00:00:00

  • Ultrastructural analysis of leucocyte interaction with tumour targets in a teleost, Cyprinus carpio L.

    abstract::The first step in natural killer activity, target cell binding, was investigated ultrastructurally in order to identify presumptive cytotoxic cells. After incubation of unfractioned peripheral blood cells of the carp, Cyprinus carpio L., with HeLa tumour cells as targets, regular conjugate forming was observed. Target...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/0145-305x(88)90055-9

    authors: Bielek E

    更新日期:1988-10-01 00:00:00

  • Diversity of the immunoglobulin heavy chain in the Atlantic salmon (Salmo salar L.) is contributed by genes from two parallel IgH isoloci.

    abstract::Immunoglobulin heavy chain (IgH) variable (V) region cDNAs from the Atlantic salmon, Salmo salar L., have been isolated and analysed with respect to diversity and transcription of the two parallel IgH isoloci in this species. A total of nine V(H) families were defined according to the 80% identity criterion, of which ...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/s0145-305x(01)00008-8

    authors: Solem ST,Hordvik I,Killie JA,Warr GW,Jørgensen TO

    更新日期:2001-06-01 00:00:00

  • Ecotoxicology and innate immunity in fish.

    abstract::This review summarizes the scattered literature on the effects of toxicants on the external and internal innate immunity of fish. Insecticides, heavy metals and surfactants have been the most frequently examined toxicants, whereas dioxins, furans and polychlorinated biphenyls have been tested less frequently. Studies ...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0145-305x(01)00040-4

    authors: Bols NC,Brubacher JL,Ganassin RC,Lee LE

    更新日期:2001-10-01 00:00:00

  • Cellular recognition of foreign materials by Bombyx mori phagocytes: I. Immunocompetent cells.

    abstract::Though Bombyx mori larvae possess five types of hemocytes in the hemolymph, the granular cells play a key role as phagocytes and also participate in the early phase of encapsulation together with plasmacytes. In this sense, these two hemocytes are regarded as immunocompetent cells in B.mori. A granular cell can intern...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章,评审

    doi:

    authors: Wago H

    更新日期:1982-10-01 00:00:00

  • The Drosophila IMD pathway in the activation of the humoral immune response.

    abstract::The IMD pathway signaling plays a pivotal role in the Drosophila defense against bacteria. During the last two decades, significant progress has been made in identifying the components and deciphering the molecular mechanisms underlying this pathway, including the means of bacterial sensing and signal transduction. Wh...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.dci.2013.05.014

    authors: Kleino A,Silverman N

    更新日期:2014-01-01 00:00:00

  • A clip domain serine proteinase plays a role in antibacterial defense but is not required for prophenoloxidase activation in shrimp.

    abstract::The clip domain serine proteinases (clip-SPs) play critical roles in the signaling processes during embryonic development and in the innate immunity of invertebrates. In the present study, we identified a homolog of the clip-SP, designated as PmClipSP1, by searching the Penaeus monodon EST database (http://pmonodon.bi...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/j.dci.2009.09.004

    authors: Amparyup P,Wiriyaukaradecha K,Charoensapsri W,Tassanakajon A

    更新日期:2010-02-01 00:00:00

  • The Drosophila Thioester containing Protein-4 participates in the induction of the cellular immune response to the pathogen Photorhabdus.

    abstract::The function of thioester-containing proteins (TEPs) in the immune defense of the fruit fly Drosophila melanogaster is yet mostly unexplored. Recently, we showed the involvement of TEP4 in the activation of humoral and phenoloxidase immune responses of Drosophila against the pathogenic bacteria Photorhabdus luminescen...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/j.dci.2017.06.008

    authors: Shokal U,Eleftherianos I

    更新日期:2017-11-01 00:00:00

  • Functional characterization of duck LSm14A in IFN-β induction.

    abstract::Human LSm14A is a key component of processing body (P-body) assembly that mediates interferon-β (IFN-β) production by sensing viral RNA or DNA. To the best of our knowledge, we are the first to report duck LSm14A (duLSm14A) cloning from duck embryo fibroblasts (DEFs). Full-length duLSm14A encoded 461 amino acids and w...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/j.dci.2017.06.014

    authors: Hua K,Li H,Chen H,Foda MF,Luo R,Jin H

    更新日期:2017-11-01 00:00:00

  • Mucosal immunity in the gut: the non-vertebrate perspective.

    abstract::Much is now known about the vertebrate mechanisms involved in mucosal immunity, and the requirement of commensal microbiota at mucosal surfaces for the proper functioning of the immune system. In comparison, very little is known about the mechanisms of immunity at the barrier epithelia of non-vertebrate organisms. The...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.dci.2013.03.009

    authors: Garcia-Garcia E,Galindo-Villegas J,Mulero V

    更新日期:2013-07-01 00:00:00

  • Relationship between circulating thyroid hormones and humoral immunity in immature male chickens.

    abstract::The objective of this experiment was to examine the relationship between levels of circulating T3, T4, and humoral immunity in immature male chickens. Three week old Single Comb White Leghorn male chicks were used as the experimental animals. In order to produce a wide range of circulating thyroid hormone concentratio...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/0145-305x(86)90029-7

    authors: Bachman SE,Mashaly MM

    更新日期:1986-07-01 00:00:00

  • Molecular cloning and characterization of novel cathelicidin-derived myeloid antimicrobial peptide from Phasianus colchicus.

    abstract::Cathelicidins were initially characterized as a family of antimicrobial peptides. Now it is clear that they fulfill several immune functions in addition to their antimicrobial activity. In the current work, three cDNA sequences encoding pheasant cathelicidins were cloned from a constructed bone marrow cDNA library of ...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/j.dci.2010.10.004

    authors: Wang Y,Lu Z,Feng F,Zhu W,Guang H,Liu J,He W,Chi L,Li Z,Yu H

    更新日期:2011-03-01 00:00:00

  • The ontogeny of the porcine immune system.

    abstract::Cellular and humoral aspects of the immune response develop sequentially in the fetus. During the ontogeny, the pluripotent stem cells emerge and differentiate into all hematopoietic lineages. Basic questions including the identification of the first lympho-hematopoietic sites, the origin of T and B lymphocytes, the d...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.dci.2008.07.011

    authors: Sinkora M,Butler JE

    更新日期:2009-03-01 00:00:00

  • Ontogeny of CTX expression in xenopus.

    abstract::In Xenopus, the type I transmembrane protein, CTX (cortical thymocyte-specific antigen of Xenopus), is hypothesized to play a role in thymocyte differentiation and/or thymic selection. The present studies were undertaken to gather additional evidence in support of a postulated association of CTX with a differentiation...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/s0145-305x(98)00028-7

    authors: Robert J,Cohen N

    更新日期:1998-09-01 00:00:00

  • Lectins and lectin-like molecules in lower plants. II. Freshwater algae.

    abstract::Freshwater chlamydomonad algae possess flagella surface isoagglutinins of a glycoprotein nature which are involved in gamete recognition and consequent cell fusion. Alternatively, such molecules may have a receptor role in certain Chlamydomonas species. In some freshwater volvocaines, lectin-like substances act as ind...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章,评审

    doi:10.1016/0145-305x(85)90002-3

    authors: Ingram GA

    更新日期:1985-07-01 00:00:00

  • Suppression of Salmonella enterica serovar Enteritidis excretion by intraocular vaccination with fimbriae proteins incorporated in liposomes.

    abstract::Liposome-associated fimbriae antigens (SEF14 and SEF21) were prepared for intraocular immunization to seek protective efficacy for intestinal infection with Salmonella enterica serovar Enteritidis. Chickens were immunized intraocularly with the antigens at 8 and 10 weeks of age. Evidence of an IgA and IgG responses we...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/s0145-305x(03)00086-7

    authors: Li W,Watarai S,Iwasaki T,Kodama H

    更新日期:2004-01-01 00:00:00

  • Molecular cloning and expression study on Toll-like receptor 5M in turbot, Scophthalmus maximus.

    abstract::Toll-like receptor 5 (TLR5) is responsible for the recognition of bacterial flagellin in mammals and play an important role in innate immunity. In the present study, a TLR5M gene was cloned from turbot, Scophthalmus maximus, and its immune responsive expression was subsequently studied in vivo. The Scophthalmus maximu...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/j.dci.2018.03.020

    authors: Liu D,Chen J,Li S,Hu G

    更新日期:2018-08-01 00:00:00

  • Regulation of FOXP3 expression in myeloid cells in response to all-trans-retinoic acid, interleukin 2 and transforming growth factor β.

    abstract::FoxP3 is a transcription factor essential for differentiation and function of T regulatory cells (Tregs). There are two major subsets of Tregs: natural Tregs (nTregs) generated in thymus and inducible Tregs (iTregs) produced in peripheral immune system. It has been documented that iTreg development is dependent on sol...

    journal_title:Developmental and comparative immunology

    pub_type: 杂志文章

    doi:10.1016/j.dci.2019.02.019

    authors: Ilnicka A,Gocek E,Łopatecka J,Marcinkowska E

    更新日期:2019-07-01 00:00:00