Abstract:
:The production of B cells and the primary antibody repertoire in mammalian species other than rodents or man appears to depend on gut-associated lymphoid tissue. Bovine B cells are generated in ileal Peyer's patch from late gestational to juvenile age. However, little is known about where and when the bona fide B lymphopoiesis takes place. We analyzed bovine fetuses for signs of ongoing B lymphopoiesis using a combination of immunohistochemistry, flow cytometry, real-time quantitative PCR and RNA in situ hybridization. In fetal bone marrow and lymph node, we could demonstrate pre-B like cells positive for intracellular Ig mu but negative for membrane IgM. Strong expression of immunoglobulin lambda-like polypeptide 1 and recombination activating genes was also detected in the same tissues. Similar analyses did not reveal pre-B like cells in the corresponding adult tissues. These results suggest that bovine fetal bone marrow and lymph node support B lymphopoiesis via a pre-B cell like stage before and in parallel to the development of the ileal Peyer's patch.
journal_name
Dev Comp Immunoljournal_title
Developmental and comparative immunologyauthors
Ekman A,Pessa-Morikawa T,Liljavirta J,Niku M,Iivanainen Adoi
10.1016/j.dci.2010.03.012subject
Has Abstractpub_date
2010-08-01 00:00:00pages
896-903issue
8eissn
0145-305Xissn
1879-0089pii
S0145-305X(10)00090-Xjournal_volume
34pub_type
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