Abstract:
:FoxP3 is a transcription factor essential for differentiation and function of T regulatory cells (Tregs). There are two major subsets of Tregs: natural Tregs (nTregs) generated in thymus and inducible Tregs (iTregs) produced in peripheral immune system. It has been documented that iTreg development is dependent on soluble mediators including interleukin 2 (IL2), transforming growth factor β (TGFβ) and all-trans-retinoic acid (ATRA). In our experiments we performed a gene expression array, followed by Real-time PCR experiments to study expression of genes regulated by ATRA in cells of myeloid origin. Our experiments revealed that ATRA alone, but also a cocktail of mediators consisting of IL2, TGFβ and ATRA, upregulate expression of FOXP3 gene in normal and leukemic myeloid cells. Our results indicate that signaling pathways which are used at the late steps of T cell differentiation, are also active in the cells of myeloid lineage.
journal_name
Dev Comp Immunoljournal_title
Developmental and comparative immunologyauthors
Ilnicka A,Gocek E,Łopatecka J,Marcinkowska Edoi
10.1016/j.dci.2019.02.019subject
Has Abstractpub_date
2019-07-01 00:00:00pages
18-26eissn
0145-305Xissn
1879-0089pii
S0145-305X(19)30002-3journal_volume
96pub_type
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