Abstract:
:Interferon regulatory factors (IRFs) are transcription factors that play important roles in immune defense, stress response, hematopoietic differentiation, and cell apoptosis. IRFs of invertebrate organisms and their functions remain largely unexplored. In the present study, for the first time new IRFs (BpIRF2 and MmIRF2) were identified in the deep-sea mussel Bathymodiolus platifrons and the shallow-water mussel Modiolus modiolus. The open reading frame of BpIRF2 and MmIRF2 encoded putative proteins of 354 and 348 amino acids, respectively. Comparison and phylogenetic analysis revealed that both IRF2 proteins were new identified invertebrate IRF molecular. As transcriptional factors, both BpIRF2 and MmIRF2 could activate the interferon-stimulated response element-containing promoter and BpIRF2 could interact with itself. Moreover, both BpIRF2 and MmIRF2 were localized to the cytoplasm and nucleus. Collectively, these results demonstrated that IRF2 proteins might be crucial in the innate immunity of deep-sea and shallow-water mussels.
journal_name
Dev Comp Immunoljournal_title
Developmental and comparative immunologyauthors
Huang B,Meng J,Yang M,Xu F,Li X,Li L,Zhang Gdoi
10.1016/j.dci.2017.01.015subject
Has Abstractpub_date
2017-06-01 00:00:00pages
82-87eissn
0145-305Xissn
1879-0089pii
S0145-305X(16)30365-2journal_volume
71pub_type
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